F234B_MOUSE
ID F234B_MOUSE Reviewed; 624 AA.
AC Q8BYI8; Q3TE07; Q5DTX5; Q8BYJ4; Q9CXB0;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Protein FAM234B;
GN Name=Fam234b {ECO:0000312|MGI:MGI:1921775}; Synonyms=Kiaa1467;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Lung, and Spinal cord;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 92-624.
RC TISSUE=Brain;
RA Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O.,
RA Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene. The
RT complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by
RT screening of terminal sequences of cDNA clones randomly sampled from size-
RT fractionated libraries.";
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30; SER-33 AND SER-63, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Liver, Pancreas, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}. Golgi outpost {ECO:0000250|UniProtKB:D3ZWJ9}.
CC Cytoplasm, cytoskeleton, microtubule organizing center
CC {ECO:0000250|UniProtKB:D3ZWJ9}. Note=Localizes to the postsynaptic
CC Golgi apparatus region, also named Golgi outpost, which shapes dendrite
CC morphology by functioning as sites of acentrosomal microtubule
CC nucleation. {ECO:0000250|UniProtKB:D3ZWJ9}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BYI8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BYI8-2; Sequence=VSP_025825;
CC -!- SIMILARITY: Belongs to the FAM234 family. {ECO:0000305}.
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DR EMBL; AK018428; BAB31206.1; -; mRNA.
DR EMBL; AK039348; BAC30325.1; -; mRNA.
DR EMBL; AK039401; BAC30340.1; -; mRNA.
DR EMBL; AK169892; BAE41441.1; -; mRNA.
DR EMBL; AK220395; BAD90448.1; -; mRNA.
DR CCDS; CCDS39681.1; -. [Q8BYI8-1]
DR RefSeq; NP_083258.2; NM_028982.4. [Q8BYI8-1]
DR AlphaFoldDB; Q8BYI8; -.
DR STRING; 10090.ENSMUSP00000107546; -.
DR GlyConnect; 2630; 5 N-Linked glycans (1 site).
DR GlyGen; Q8BYI8; 1 site, 5 N-linked glycans (1 site).
DR iPTMnet; Q8BYI8; -.
DR PhosphoSitePlus; Q8BYI8; -.
DR EPD; Q8BYI8; -.
DR MaxQB; Q8BYI8; -.
DR PaxDb; Q8BYI8; -.
DR PRIDE; Q8BYI8; -.
DR ProteomicsDB; 275830; -. [Q8BYI8-1]
DR ProteomicsDB; 275831; -. [Q8BYI8-2]
DR Antibodypedia; 2254; 49 antibodies from 11 providers.
DR Ensembl; ENSMUST00000111915; ENSMUSP00000107546; ENSMUSG00000030207. [Q8BYI8-1]
DR Ensembl; ENSMUST00000111916; ENSMUSP00000107547; ENSMUSG00000030207. [Q8BYI8-2]
DR GeneID; 74525; -.
DR KEGG; mmu:74525; -.
DR UCSC; uc009eli.2; mouse. [Q8BYI8-1]
DR CTD; 57613; -.
DR MGI; MGI:1921775; Fam234b.
DR VEuPathDB; HostDB:ENSMUSG00000030207; -.
DR eggNOG; ENOG502QVNA; Eukaryota.
DR GeneTree; ENSGT00530000063694; -.
DR HOGENOM; CLU_029706_0_0_1; -.
DR InParanoid; Q8BYI8; -.
DR OMA; FFQHSAN; -.
DR OrthoDB; 294858at2759; -.
DR PhylomeDB; Q8BYI8; -.
DR TreeFam; TF327203; -.
DR BioGRID-ORCS; 74525; 4 hits in 42 CRISPR screens.
DR ChiTaRS; Fam234b; mouse.
DR PRO; PR:Q8BYI8; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q8BYI8; protein.
DR Bgee; ENSMUSG00000030207; Expressed in subiculum and 239 other tissues.
DR ExpressionAtlas; Q8BYI8; baseline and differential.
DR Genevisible; Q8BYI8; MM.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR045232; FAM234.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR21419; PTHR21419; 1.
DR SUPFAM; SSF50998; SSF50998; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Cytoskeleton; Golgi apparatus; Membrane;
KW Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..624
FT /note="Protein FAM234B"
FT /id="PRO_0000288914"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 16
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A2RU67"
FT MOD_RES 26
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:A2RU67"
FT MOD_RES 30
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 33
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 63
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 624
FT /note="I -> AGEMAQCVLAKPGYLNLIPWPHMLEGGNGVLHTVL (in isoform
FT 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_025825"
FT CONFLICT 250
FT /note="N -> D (in Ref. 2; BAD90448)"
FT /evidence="ECO:0000305"
FT CONFLICT 419
FT /note="T -> M (in Ref. 2; BAD90448)"
FT /evidence="ECO:0000305"
FT CONFLICT 544
FT /note="I -> V (in Ref. 1; BAB31206)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 624 AA; 67031 MW; 2C377FE4B3A2F17E CRC64;
MATVLSRALK LPGKKSPDLG EYDPLTQADS DESEDDLVLN LQQKNGGVKN GKSALGDLPE
PDSDADVAGA AKPHLSEVTP EGFPSEPLGG LEQKATSPLV SYVRTSVFLL TLVISMVLVL
LCAFLIPCPP RDLHSAWSRR LGSQGGGDLS PLELADVNRD GLRDVLLTFV TTRNGTEGGV
GSQPTADLVC LSGMNGSTLW SSPLPEEAQD VTCLDLIPGS VAKTICLVTG TRKMLSAFNA
TSGKVLWTLN PNHLSNGTLA APVVVLPDLD EDGVRDLVVL AIGELQPDLC FLLVSGRTGS
PVGRPVKYNI VGVGNLIGPQ VYITASGAVY ILFGFGNIQA VALRDIFVQA QNRDSSPPSL
QIEEPEWEKH RSVNLSELID VYSDGVELLQ LVKAPDSNSS SLLITTRQGL VLLRGQDLTP
HWKLNLQGLR SQPTPGYFTD DQTLDFLLQT QDGDGMKKMT VVDGGSGSIV WSYSIPCHMK
ETPTTSAITS DQKSVFLFWA EALTAASLSS DDSSGAEPPG LYHLYLLHPA FPSILLDLSN
TTGIVTASEV GINDIWKDAF YVTRTTGMSP EGHPTSLVVS KLSLRWALME GQMVQLKETT
PKIGRGELRR FLSRIKFVDS PYQI
