F234B_RAT
ID F234B_RAT Reviewed; 624 AA.
AC D3ZWJ9;
DT 13-NOV-2019, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=Protein FAM234B {ECO:0000305};
GN Name=Fam234b {ECO:0000312|RGD:1306151};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
RN [4]
RP SUBCELLULAR LOCATION.
RX PubMed=31522887; DOI=10.1016/j.cell.2019.08.025;
RA Fu M.M., McAlear T.S., Nguyen H., Oses-Prieto J.A., Valenzuela A.,
RA Shi R.D., Perrino J.J., Huang T.T., Burlingame A.L., Bechstedt S.,
RA Barres B.A.;
RT "The Golgi outpost protein TPPP nucleates microtubules and is critical for
RT myelination.";
RL Cell 0:0-0(2019).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}. Golgi outpost {ECO:0000269|PubMed:31522887}.
CC Cytoplasm, cytoskeleton, microtubule organizing center
CC {ECO:0000269|PubMed:31522887}. Note=Localizes to the postsynaptic Golgi
CC apparatus region, also named Golgi outpost, which shapes dendrite
CC morphology by functioning as sites of acentrosomal microtubule
CC nucleation. {ECO:0000269|PubMed:31522887}.
CC -!- SIMILARITY: Belongs to the FAM234 family. {ECO:0000305}.
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DR EMBL; AABR07062325; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH473964; EDM01628.1; -; Genomic_DNA.
DR RefSeq; NP_001102122.1; NM_001108652.1.
DR AlphaFoldDB; D3ZWJ9; -.
DR STRING; 10116.ENSRNOP00000063612; -.
DR iPTMnet; D3ZWJ9; -.
DR PhosphoSitePlus; D3ZWJ9; -.
DR jPOST; D3ZWJ9; -.
DR PaxDb; D3ZWJ9; -.
DR PeptideAtlas; D3ZWJ9; -.
DR PRIDE; D3ZWJ9; -.
DR GeneID; 362455; -.
DR KEGG; rno:362455; -.
DR CTD; 57613; -.
DR RGD; 1306151; Fam234b.
DR VEuPathDB; HostDB:ENSRNOG00000008443; -.
DR eggNOG; ENOG502QVNA; Eukaryota.
DR HOGENOM; CLU_029706_0_0_1; -.
DR InParanoid; D3ZWJ9; -.
DR OMA; FFQHSAN; -.
DR OrthoDB; 294858at2759; -.
DR PRO; PR:D3ZWJ9; -.
DR Proteomes; UP000002494; Chromosome 4.
DR Proteomes; UP000234681; Chromosome 4.
DR Bgee; ENSRNOG00000008443; Expressed in frontal cortex and 20 other tissues.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR045232; FAM234.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR21419; PTHR21419; 1.
DR SUPFAM; SSF50998; SSF50998; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Cytoskeleton; Golgi apparatus; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..624
FT /note="Protein FAM234B"
FT /id="PRO_0000448594"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 16
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A2RU67"
FT MOD_RES 26
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:A2RU67"
FT MOD_RES 30
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A2RU67"
FT MOD_RES 33
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A2RU67"
FT MOD_RES 63
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A2RU67"
SQ SEQUENCE 624 AA; 67040 MW; 61E05717F83E3CB6 CRC64;
MATVLSRALK LPGKKSPDLG EYDPLTQADS DESEDDLVLN LQQKNGGVKN GKSALGDPPE
PDSDADVAGA SKPHLSEVTP EGFPSEPLGG LEQKATSSLV SYVRTSVFLL TLVISMVLVL
LCAFLIPCPP RDLHSTWSRR LGSQGGGDLS PLELADVNRD GLRDVLLTFV TTRNGTEGGG
GSQPTADLVC LSGMNGSTLW SSPLPEEAQD VTCLDLIPGS VAKTICLVTG TRKMLSAFNA
TSGKILWTLN PNYLSNGTLA APVVVLPDLD EDGVRDLVVL AIGELQPDLC FLLVSGRTGS
PVGRPVKYNI VGVGNLIGPQ VYITASGAVY ILFGFGNIQA VALRDIFVQA QNRDSSPPSL
QIEEPEWEKH RSVNLSELID VYSDGVELLQ LVKAPDSNSS SLLITTRQGL VLLRGQDLTP
HWKLNLQGLR SQPTPGYFTD DQTLDFLLQT QDGVGMKKMT VVDGSSGSIV WSYRVPCHVK
ETPTTSAITS DQKSVFLFWA EALTAASLSS DDSSGAEPSG LYHLYLLHPA FPSVLLDLSN
TTGIVTAAEV GVNDIWKDAF YVTRTTGMSP EGHTTSLVVS KLSLRWGLME GQMVQLKETT
PKIGRGELRR FLSRIKFVDS PYQM
