F241A_HUMAN
ID F241A_HUMAN Reviewed; 132 AA.
AC Q8N8J7; Q49A91; Q4W5C7; Q8TBF9;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Uncharacterized protein FAM241A;
GN Name=FAM241A {ECO:0000312|HGNC:HGNC:26813}; Synonyms=C4orf32;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLN-46.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the FAM241 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK096689; BAC04841.1; -; mRNA.
DR EMBL; AC093663; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC109347; AAY40961.1; -; Genomic_DNA.
DR EMBL; BC022534; AAH22534.1; -; mRNA.
DR CCDS; CCDS3695.1; -.
DR RefSeq; NP_689613.1; NM_152400.2.
DR AlphaFoldDB; Q8N8J7; -.
DR BioGRID; 126333; 81.
DR IntAct; Q8N8J7; 21.
DR STRING; 9606.ENSP00000310182; -.
DR GlyGen; Q8N8J7; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q8N8J7; -.
DR PhosphoSitePlus; Q8N8J7; -.
DR BioMuta; FAM241A; -.
DR EPD; Q8N8J7; -.
DR jPOST; Q8N8J7; -.
DR MassIVE; Q8N8J7; -.
DR MaxQB; Q8N8J7; -.
DR PaxDb; Q8N8J7; -.
DR PeptideAtlas; Q8N8J7; -.
DR PRIDE; Q8N8J7; -.
DR ProteomicsDB; 72431; -.
DR Antibodypedia; 54648; 9 antibodies from 4 providers.
DR DNASU; 132720; -.
DR Ensembl; ENST00000309733.6; ENSP00000310182.4; ENSG00000174749.6.
DR GeneID; 132720; -.
DR KEGG; hsa:132720; -.
DR MANE-Select; ENST00000309733.6; ENSP00000310182.4; NM_152400.3; NP_689613.2.
DR UCSC; uc003iah.3; human.
DR CTD; 132720; -.
DR GeneCards; FAM241A; -.
DR HGNC; HGNC:26813; FAM241A.
DR HPA; ENSG00000174749; Low tissue specificity.
DR neXtProt; NX_Q8N8J7; -.
DR OpenTargets; ENSG00000174749; -.
DR PharmGKB; PA162379734; -.
DR VEuPathDB; HostDB:ENSG00000174749; -.
DR eggNOG; ENOG502S3RI; Eukaryota.
DR GeneTree; ENSGT00940000154340; -.
DR HOGENOM; CLU_160107_0_0_1; -.
DR InParanoid; Q8N8J7; -.
DR OMA; MCSAGQL; -.
DR OrthoDB; 1471528at2759; -.
DR PhylomeDB; Q8N8J7; -.
DR TreeFam; TF335755; -.
DR PathwayCommons; Q8N8J7; -.
DR SignaLink; Q8N8J7; -.
DR BioGRID-ORCS; 132720; 16 hits in 1073 CRISPR screens.
DR GenomeRNAi; 132720; -.
DR Pharos; Q8N8J7; Tdark.
DR PRO; PR:Q8N8J7; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q8N8J7; protein.
DR Bgee; ENSG00000174749; Expressed in parietal pleura and 173 other tissues.
DR Genevisible; Q8N8J7; HS.
DR GO; GO:0005794; C:Golgi apparatus; IDA:HPA.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR InterPro; IPR027953; DUF4605.
DR Pfam; PF15378; DUF4605; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..132
FT /note="Uncharacterized protein FAM241A"
FT /id="PRO_0000286629"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..25
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..66
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 46
FT /note="P -> Q (in dbSNP:rs17852081)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_032150"
FT CONFLICT 32
FT /note="G -> E (in Ref. 1; BAC04841 and 3; AAH22534)"
FT /evidence="ECO:0000305"
FT CONFLICT 39
FT /note="P -> Q (in Ref. 3; AAH22534)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 132 AA; 14653 MW; F869541803B17C88 CRC64;
MCSAGELLRG GDGGERDEDG DALAEREAAG TGWDPGASPR RRGQRPKESE QDVEDSQNHT
GEPVGDDYKK MGTLFGELNK NLINMGFTRM YFGERIVEPV IVIFFWVMLW FLGLQALGLV
AVLCLVIIYV QQ
