F241A_MOUSE
ID F241A_MOUSE Reviewed; 131 AA.
AC Q9CZL2;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Uncharacterized protein FAM241A;
GN Name=Fam241a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Kidney, Liver, Lung, Pancreas, Spleen, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the FAM241 family. {ECO:0000305}.
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DR EMBL; AK012470; BAB28264.1; -; mRNA.
DR EMBL; AK162420; BAE36906.1; -; mRNA.
DR EMBL; BC116791; AAI16792.1; -; mRNA.
DR EMBL; BC116793; AAI16794.1; -; mRNA.
DR CCDS; CCDS17829.1; -.
DR RefSeq; NP_081758.1; NM_027482.3.
DR AlphaFoldDB; Q9CZL2; -.
DR SMR; Q9CZL2; -.
DR STRING; 10090.ENSMUSP00000062387; -.
DR iPTMnet; Q9CZL2; -.
DR PhosphoSitePlus; Q9CZL2; -.
DR EPD; Q9CZL2; -.
DR MaxQB; Q9CZL2; -.
DR PaxDb; Q9CZL2; -.
DR PRIDE; Q9CZL2; -.
DR ProteomicsDB; 275517; -.
DR Antibodypedia; 54648; 9 antibodies from 4 providers.
DR DNASU; 70617; -.
DR Ensembl; ENSMUST00000199273; ENSMUSP00000142535; ENSMUSG00000050549.
DR GeneID; 70617; -.
DR KEGG; mmu:70617; -.
DR UCSC; uc008rhr.2; mouse.
DR CTD; 132720; -.
DR MGI; MGI:1917867; Fam241a.
DR VEuPathDB; HostDB:ENSMUSG00000050549; -.
DR eggNOG; ENOG502S3RI; Eukaryota.
DR GeneTree; ENSGT00940000154340; -.
DR HOGENOM; CLU_2903573_0_0_1; -.
DR InParanoid; Q9CZL2; -.
DR OMA; MCSAGQL; -.
DR OrthoDB; 1471528at2759; -.
DR PhylomeDB; Q9CZL2; -.
DR TreeFam; TF335755; -.
DR BioGRID-ORCS; 70617; 3 hits in 41 CRISPR screens.
DR PRO; PR:Q9CZL2; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q9CZL2; protein.
DR Bgee; ENSMUSG00000050549; Expressed in conjunctival fornix and 190 other tissues.
DR ExpressionAtlas; Q9CZL2; baseline and differential.
DR Genevisible; Q9CZL2; MM.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR InterPro; IPR027953; DUF4605.
DR Pfam; PF15378; DUF4605; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..131
FT /note="Uncharacterized protein FAM241A"
FT /id="PRO_0000286630"
FT TRANSMEM 99..119
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..65
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 14
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 131 AA; 14511 MW; 2F4937AAADFFF169 CRC64;
MCSARKLLRG GAGSAGGECD EDGAAPAGRV EEPEHGASPR RRRPQDEGEQ DIEEPQNHSG
EPIGDDYKKM GTLFGELNKN LLNMGFTRMY FGERIVEPVV VLFFWLMLWF LGLQALGLVA
VLCLVIIYVQ Q
