F241B_MOUSE
ID F241B_MOUSE Reviewed; 120 AA.
AC Q9D882;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Protein FAM241B {ECO:0000305};
GN Name=Fam241b {ECO:0000312|MGI:MGI:1917144};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Small intestine, and Urinary bladder;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Pancreas, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May play a role in lysosome homeostasis.
CC {ECO:0000250|UniProtKB:Q96D05}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the FAM241 family. {ECO:0000305}.
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DR EMBL; AK008338; BAB25613.1; -; mRNA.
DR EMBL; AK035688; BAC29152.1; -; mRNA.
DR EMBL; BC024943; AAH24943.1; -; mRNA.
DR CCDS; CCDS23886.1; -.
DR RefSeq; NP_081527.1; NM_027251.3.
DR RefSeq; XP_006514126.1; XM_006514063.1.
DR RefSeq; XP_006514127.1; XM_006514064.2.
DR AlphaFoldDB; Q9D882; -.
DR SMR; Q9D882; -.
DR IntAct; Q9D882; 6.
DR MINT; Q9D882; -.
DR STRING; 10090.ENSMUSP00000116424; -.
DR iPTMnet; Q9D882; -.
DR PhosphoSitePlus; Q9D882; -.
DR MaxQB; Q9D882; -.
DR PaxDb; Q9D882; -.
DR PRIDE; Q9D882; -.
DR ProteomicsDB; 275569; -.
DR DNASU; 69894; -.
DR Ensembl; ENSMUST00000064050; ENSMUSP00000063504; ENSMUSG00000020083.
DR Ensembl; ENSMUST00000124615; ENSMUSP00000118912; ENSMUSG00000020083.
DR Ensembl; ENSMUST00000125704; ENSMUSP00000115865; ENSMUSG00000020083.
DR Ensembl; ENSMUST00000142796; ENSMUSP00000116424; ENSMUSG00000020083.
DR Ensembl; ENSMUST00000142821; ENSMUSP00000119289; ENSMUSG00000020083.
DR GeneID; 69894; -.
DR KEGG; mmu:69894; -.
DR UCSC; uc007fgs.1; mouse.
DR CTD; 219738; -.
DR MGI; MGI:1917144; Fam241b.
DR VEuPathDB; HostDB:ENSMUSG00000020083; -.
DR eggNOG; ENOG502S2ZQ; Eukaryota.
DR GeneTree; ENSGT00940000170705; -.
DR HOGENOM; CLU_138765_1_0_1; -.
DR InParanoid; Q9D882; -.
DR OMA; RQGFLNR; -.
DR OrthoDB; 1622897at2759; -.
DR PhylomeDB; Q9D882; -.
DR TreeFam; TF335755; -.
DR BioGRID-ORCS; 69894; 1 hit in 75 CRISPR screens.
DR ChiTaRS; Fam241b; mouse.
DR PRO; PR:Q9D882; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q9D882; protein.
DR Bgee; ENSMUSG00000020083; Expressed in animal zygote and 226 other tissues.
DR ExpressionAtlas; Q9D882; baseline and differential.
DR Genevisible; Q9D882; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR InterPro; IPR027953; DUF4605.
DR Pfam; PF15378; DUF4605; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..120
FT /note="Protein FAM241B"
FT /id="PRO_0000089791"
FT TRANSMEM 91..111
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 12..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 61
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96D05"
SQ SEQUENCE 120 AA; 13118 MW; 92C337D6CC6B4460 CRC64;
MVRILANGEI VQDDDPRVRT TTQHRSSSSQ QGFFNRGHGA PPGGPGPRQQ QAGARLGAAQ
SPFSDLNRQL VNMGFPQWHL GNHVVEPVTS ILLLFLLMML GVRGLLLVGL VYLVSHLSQR
