ID   F243A_HUMAN             Reviewed;         251 AA.
AC   B9A014;
DT   25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Uncharacterized protein C21orf140 {ECO:0000305};
DE   AltName: Full=Protein FAM243A {ECO:0000305};
GN   Name=C21orf140 {ECO:0000312|HGNC:HGNC:39602};
GN   Synonyms=FAM243A {ECO:0000312|HGNC:HGNC:39602};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10830953; DOI=10.1038/35012518;
RA   Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA   Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA   Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA   Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA   Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA   Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA   Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA   Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA   Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA   Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA   Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT   "The DNA sequence of human chromosome 21.";
RL   Nature 405:311-319(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 148-251.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SIMILARITY: Belongs to the FAM243 family. {ECO:0000305}.
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DR   EMBL; AP000322; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AW664693; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS63357.1; -.
DR   RefSeq; NP_001269466.1; NM_001282537.1.
DR   RefSeq; XP_006724008.1; XM_006723945.3.
DR   RefSeq; XP_006726860.1; XM_006726797.3.
DR   AlphaFoldDB; B9A014; -.
DR   IntAct; B9A014; 1.
DR   STRING; 9606.ENSP00000386791; -.
DR   BioMuta; C21orf140; -.
DR   PaxDb; B9A014; -.
DR   PRIDE; B9A014; -.
DR   Antibodypedia; 49023; 5 antibodies from 5 providers.
DR   DNASU; 101928147; -.
DR   Ensembl; ENST00000410005.2; ENSP00000386791.1; ENSG00000222018.2.
DR   GeneID; 101928147; -.
DR   KEGG; hsa:101928147; -.
DR   MANE-Select; ENST00000410005.2; ENSP00000386791.1; NM_001282537.2; NP_001269466.1.
DR   UCSC; uc032pyo.2; human.
DR   CTD; 101928147; -.
DR   GeneCards; FAM243A; -.
DR   HGNC; HGNC:39602; C21orf140.
DR   HPA; ENSG00000222018; Tissue enhanced (testis).
DR   neXtProt; NX_B9A014; -.
DR   VEuPathDB; HostDB:ENSG00000222018; -.
DR   eggNOG; ENOG502RXAQ; Eukaryota.
DR   GeneTree; ENSGT00390000010669; -.
DR   HOGENOM; CLU_1106831_0_0_1; -.
DR   OMA; CCLAVAH; -.
DR   OrthoDB; 969823at2759; -.
DR   PhylomeDB; B9A014; -.
DR   BioGRID-ORCS; 101928147; 4 hits in 843 CRISPR screens.
DR   BioGRID-ORCS; 102723451; 0 hits in 4 CRISPR screens.
DR   Pharos; B9A014; Tdark.
DR   PRO; PR:B9A014; -.
DR   Proteomes; UP000005640; Chromosome 21.
DR   RNAct; B9A014; protein.
DR   Bgee; ENSG00000222018; Expressed in superior frontal gyrus and 95 other tissues.
DR   InterPro; IPR037728; C21orf140-like.
DR   PANTHER; PTHR35969; PTHR35969; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..251
FT                   /note="Uncharacterized protein C21orf140"
FT                   /id="PRO_0000415166"
SQ   SEQUENCE   251 AA;  29214 MW;  6B131B1C92FBA015 CRC64;
     MPRFASPLLR NVIIRSQFDG IKRKQCLQYL KTLRTLQYDG FKTVYFGETN IPESLVTGED
     ISDGYFIQTP TWCIVHAAGS QGWVPWKYRV FLRDELCIKQ EDSLFSEFCD VVRKAYGKCV
     IVVKERRQQE EQRPKEDREA EGQFYIPTVI SLASIMCCPE VAKSCGHELL SLPSPCNYLN
     PLDSAWSSLK WFIINNRNEF CLQSIDSGYS YQCILFSNLI SKGIERINAS KWRTLTSKVR
     RWENYYLGKF S