ID   F256_CTEON              Reviewed;          32 AA.
AC   P85032;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 1.
DT   25-MAY-2022, entry version 22.
DE   RecName: Full=U21-ctenitoxin-Co1a;
DE            Short=U21-CNTX-Co1a;
DE   AltName: Full=Venom peptide Oct F25-6;
OS   Ctenus ornatus (Brazilian spider) (Oligoctenus ornatus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Araneomorphae; Entelegynae; Lycosoidea; Ctenidae; Oligoctenus.
OX   NCBI_TaxID=406443;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Venom {ECO:0000269|Ref.1};
RA   Richardson M., Goncalves J.M., Oliveira C.F.B., Borges M.H.,
RA   Bemquerer M.P., Rates B.A., Pimenta A.M.C., Cordeiro M.N.;
RT   "New 3.5kDa peptide from venom of Brazilian spider Oligoctenus ornatus has
RT   strong sequence similarities to neurotoxins from the genus Phoneutria and
RT   various conotoxins.";
RL   Submitted (OCT-2006) to UniProtKB.
CC   -!- FUNCTION: Not toxic to mice by intracerebroventricular injection.
CC       {ECO:0000269|Ref.1}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|Ref.1}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- MASS SPECTROMETRY: Mass=3517.74; Mass_error=0.01; Method=Electrospray;
CC       Evidence={ECO:0000269|Ref.1};
CC   -!- SIMILARITY: Belongs to the neurotoxin 17 (21C2) family. {ECO:0000255}.
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DR   AlphaFoldDB; P85032; -.
DR   SMR; P85032; -.
DR   ArachnoServer; AS000041; U21-ctenitoxin-Co1a.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR012634; Toxin_29.
DR   Pfam; PF08116; Toxin_29; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Knottin; Secreted.
FT   PEPTIDE         1..32
FT                   /note="U21-ctenitoxin-Co1a"
FT                   /id="PRO_0000262764"
FT   DISULFID        3..17
FT                   /evidence="ECO:0000250"
FT   DISULFID        10..21
FT                   /evidence="ECO:0000250"
FT   DISULFID        16..30
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   32 AA;  3524 MW;  67B3995B072C4B9B CRC64;
     APCTYPGQQC KSDDECCHGT CKTAFIGRIC MR