F25A2_MOUSE
ID F25A2_MOUSE Reviewed; 1308 AA.
AC C0HKD1; A2APU8;
DT 18-JUL-2018, integrated into UniProtKB/Swiss-Prot.
DT 18-JUL-2018, sequence version 1.
DT 03-AUG-2022, entry version 16.
DE RecName: Full=Protein FAM205A-2 {ECO:0000312|MGI:MGI:3701946};
GN Name=Fam205a2 {ECO:0000312|MGI:MGI:3701946};
GN Synonyms=Gm13298 {ECO:0000312|MGI:MGI:3701946};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the FAM205 family. {ECO:0000305}.
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DR EMBL; BX666061; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001078999.1; NM_001085530.1.
DR RefSeq; XP_001481289.2; XM_001481239.5.
DR RefSeq; XP_003688841.1; XM_003688793.4.
DR RefSeq; XP_003689294.1; XM_003689246.4.
DR AlphaFoldDB; C0HKD1; -.
DR STRING; 10090.ENSMUSP00000103661; -.
DR PhosphoSitePlus; C0HKD1; -.
DR Ensembl; ENSMUST00000108026; ENSMUSP00000103661; ENSMUSG00000078746.
DR Ensembl; ENSMUST00000178192; ENSMUSP00000137159; ENSMUSG00000093996.
DR Ensembl; ENSMUST00000180201; ENSMUSP00000136864; ENSMUSG00000094066.
DR GeneID; 100043920; -.
DR GeneID; 100862261; -.
DR GeneID; 545611; -.
DR KEGG; mmu:545611; -.
DR CTD; 100043920; -.
DR CTD; 100862261; -.
DR CTD; 545611; -.
DR MGI; MGI:3701946; Fam205a2.
DR VEuPathDB; HostDB:ENSMUSG00000078746; -.
DR VEuPathDB; HostDB:ENSMUSG00000079774; -.
DR VEuPathDB; HostDB:ENSMUSG00000093996; -.
DR VEuPathDB; HostDB:ENSMUSG00000094066; -.
DR OMA; PNTMASL; -.
DR PRO; PR:C0HKD1; -.
DR Proteomes; UP000000589; Chromosome 4.
DR Bgee; ENSMUSG00000078746; Expressed in spermatid and 14 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR027970; DUF4599.
DR InterPro; IPR039509; SPATA31/FAM205.
DR Pfam; PF15371; DUF4599; 1.
DR Pfam; PF14650; FAM75; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..1308
FT /note="Protein FAM205A-2"
FT /id="PRO_0000341305"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 464..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 627..648
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 844..863
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 902..927
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1005..1026
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1084..1190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1204..1254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 902..925
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1146..1160
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1209..1223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1308 AA; 146156 MW; 2AD7B16B2FD8C62D CRC64;
MLSTMCFLWD TECPLYVYFC FFIIVLIVWQ VRQNYQGLKC ENRRSCCRRH QKVRQRAKDA
ASRARRLSRE EDEKPCELLS IMKSQSWVPK QGNVRQLLCL DPSCQICEAT TLEIRQLLQS
KKSQISPALL GLPQRAACLE MPISSESFEW NQDFYSRYST NSPVVPGNQT LTQLTEELTE
STNADGVLLC WTDPLQIGQE FHLADMPMAS ETLVSPGLEE PVVLMNEEDT VHSNLNYIQQ
LQDHEALNSQ IPFQTLTPQL TVTHPMAVSI VTDAPQPFLS PEVLRLLEIH VKKLMHFQRW
GLPRRVEESL KQFMPNPPVY LPPEHNQPVS FILNTSSQDC VHRFEGISPE TWYSYMDGQP
IQTFWVSEWS SGDQGQRLSC KPIPSPVEKP LLTPDYELLH DLCLSPEGQV DGSQSNLQKK
FTQLFCGLPS MHSESLGSTF LCTQGVSKNT LKPPYKEPHF LKVSPPIPLP EAAPPPSSTS
PNESLDEPQR AQIGGVPFLT LSECKTLEWH LLQRQLQLQW GLPAVIARPP RVQSHTQYKH
KPWNKAKPRE TLKFFGPGKP FSALTRELFF IPQHARRLLE FHLQKRLIHL RWGLPQRIQR
SINMLLSSTD LQSLPCGGSR LPNVSISQPG KPEAYGSGDT FLPTAGKGTT PMPHLFAKAQ
EMLKSHDTKC EQIREGKVPA CVQSAWKGRI PGDLAAGTLF PNIPQGQPLE LQAENNPDLH
QEAVSWKPMD LDQEAQAFSG VFIEHCRRPQ ALSEETIKKL ETTLRHKYLA FLSGLQALYC
MAPTKATSPT VDQSVITTMP WSVKSPQKPL SQKSPLEALC LSGLEPCTQD DKETSANIAE
EFQHGAQGHG RTEKVPPERQ PLLNRPYSLD TEIMERVSFY LKRKALDIKL GISLKESVFQ
EPTATDLESE SVQEPLGSPR ESTLLQGPPT LCHVPVAPDP DKVCLKQPAT AVQVVFQEQN
QPSSRAVPHR SARQGSQVHR NMMEAQVHYV QMGTGGEMLN LGEPFSTESQ SPGKSKSGYV
PTVAGKRKIP GKPKVVGDLG EGDAGLGFSL VSLKTRQDGE QEKRLLHRQL QGSSLQAQTF
HLEGACPHSP QESPELQFAD PPPEVFMETD SEQDMEDSQS KESIVPEPAR TAKAPQPMLS
RASQGLPFPR SPTQRKPSQG QPGPGHVPPG HATPASPYTR PSRLPEAGLK NKMKLFFHSI
KLKMKSKAHT EPSTVSTPGK VAKTSKENID RGLPQAKSPT KKTKPEDFRG PKAQFSVVGP
CLTPSYILDS KFWPRPRRVG SVSVLGHSYH CPRHCPRLAY ANQQRNPP
