ID   F3_VACCA                Reviewed;         476 AA.
AC   O57174;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   02-JUN-2021, entry version 76.
DE   RecName: Full=Kelch repeat protein F3;
GN   OrderedLocusNames=MVA031L, ACAM3000_MVA_031;
OS   Vaccinia virus (strain Ankara) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=126794;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9601507; DOI=10.1006/viro.1998.9123;
RA   Antoine G., Scheiflinger F., Dorner F., Falkner F.G.;
RT   "The complete genomic sequence of the modified vaccinia Ankara strain:
RT   comparison with other orthopoxviruses.";
RL   Virology 244:365-396(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate Acambis 3000;
RA   Esposito J.J., Frace M., Sammons S.A., Olsen-Rasmussen M.S., Osborne J.,
RA   Khristova M., Wohlhueter R.M.;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Might have a role in the suppression of host immune response.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviruses Kelch family. {ECO:0000305}.
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DR   EMBL; U94848; AAB96414.1; -; Genomic_DNA.
DR   EMBL; AY603355; AAT10429.1; -; Genomic_DNA.
DR   PIR; T30781; T30781.
DR   SMR; O57174; -.
DR   Proteomes; UP000159908; Genome.
DR   Proteomes; UP000172909; Genome.
DR   Gene3D; 2.120.10.80; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 3.
DR   SMART; SM00612; Kelch; 3.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   3: Inferred from homology;
KW   Kelch repeat; Repeat.
FT   CHAIN           1..476
FT                   /note="Kelch repeat protein F3"
FT                   /id="PRO_0000119165"
FT   DOMAIN          10..90
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          125..218
FT                   /note="BACK"
FT   REPEAT          269..315
FT                   /note="Kelch 1"
FT   REPEAT          316..359
FT                   /note="Kelch 2"
FT   REPEAT          361..404
FT                   /note="Kelch 3"
FT   REPEAT          406..443
FT                   /note="Kelch 4"
FT   REPEAT          444..476
FT                   /note="Kelch 5"
SQ   SEQUENCE   476 AA;  55299 MW;  3D2891458BDB42FA CRC64;
     MPIFVNTVYC KNILALSMTK KFKTIIDAIG GNIIVNSTIL KKLSPYFRTH LRQKYTKNKD
     PVTRVCLDLD IHSLTSIVIY SYTGKVYIDS HNVVNLLRAS ILTSVEFIIY TCINFILRDF
     RKEYCVECYM MGIEYGLSNL LCHTKNFIAK HFLELEDDII DNFDYLSMKL ILESDELNVP
     DEDFVIKWYI KRRNKLGNLL LLIKNVIRSN YLSPRGINNV KWILDCTKIF HCDKQPRKSY
     KYPFIEYPMN MDQIIDIFHM CTSTHVGEVV YLIGGWMNNE IHNNAIAVNY ISNNWIPIPP
     MNSPRLYASG IPANNKLYVV GGLPNPTSVE RWFHGDAAWV NMPSLLKPRC NPAVASINNV
     IYVMGGHSET DTTTEYLLPN HDQWQFGPST YYPHYKSCAL VFGRRLFLVG RNAEFYCESS
     NTWTLIDDPI YPRDNPELII VDNKLLLIGG FYRESYIDTI EVYNHHTYSW NIWDGK