ID   F3_VACCC                Reviewed;         480 AA.
AC   P21013;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   29-SEP-2021, entry version 85.
DE   RecName: Full=Kelch repeat protein F3;
GN   ORFNames=F3L;
OS   Vaccinia virus (strain Copenhagen) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10249;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2219722; DOI=10.1016/0042-6822(90)90294-2;
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "The complete DNA sequence of vaccinia virus.";
RL   Virology 179:247-266(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "Appendix to 'The complete DNA sequence of vaccinia virus'.";
RL   Virology 179:517-563(1990).
CC   -!- FUNCTION: Might have a role in the suppression of host immune response.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviruses Kelch family. {ECO:0000305}.
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DR   EMBL; M35027; AAA48016.1; -; Genomic_DNA.
DR   PIR; H42506; H42506.
DR   SMR; P21013; -.
DR   Proteomes; UP000008269; Genome.
DR   Gene3D; 2.120.10.80; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 3.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00612; Kelch; 3.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   3: Inferred from homology;
KW   Kelch repeat; Reference proteome; Repeat.
FT   CHAIN           1..480
FT                   /note="Kelch repeat protein F3"
FT                   /id="PRO_0000119166"
FT   DOMAIN          10..90
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          125..223
FT                   /note="BACK"
FT   REPEAT          273..319
FT                   /note="Kelch 1"
FT   REPEAT          320..363
FT                   /note="Kelch 2"
FT   REPEAT          365..408
FT                   /note="Kelch 3"
FT   REPEAT          410..447
FT                   /note="Kelch 4"
FT   REPEAT          448..480
FT                   /note="Kelch 5"
SQ   SEQUENCE   480 AA;  55717 MW;  1F5AA994E0504DB2 CRC64;
     MPIFVNTVYC KNILALSMTK KFKTIIDAIG GNIIVNSTIL KKLSPYFRTH LRQKYTKNKD
     PVTRVCLDLD IHSLTSIVIY SYTGKVYIDS HNVVNLLRAS ILTSVEFIIY TCINFILRDF
     RKEYCVECYM MGIEYGLSNL LCHTKNFIAK HFLELEDDII DNFDYLSMKL ILESDELNVP
     DEDYVVDFVI KWYIKRRNKL GNLLLLIKNV IRSNYLSPRG INNVKWILDC TKIFHCDKQP
     RKSYKYPFIE YPMNMDQIID IFHMCTSTHV GEVVYLIGGW MNNEIHNNAI AVNYISNNWI
     PIPPMNSPRL YATGIPANNK LYVVGGLPNP TSVERWFHGD AAWVNMPSLL KPRCNPAVAS
     INNVIYVMGG HSETDTTTEY LLPNHDQWQF GPSTYYPHYK SCALVFGRRL FLVGRNAEFY
     CESSNTWTLI DDPIYPRDNP ELIIVDNKLL LIGGFYRGSY IDTIEVYNHH TYSWNIWDGK