ID   F3_VACCW                Reviewed;         480 AA.
AC   P24357; Q80HX9;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   02-JUN-2021, entry version 81.
DE   RecName: Full=Kelch repeat protein F3;
GN   OrderedLocusNames=VACWR042; ORFNames=F3L;
OS   Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
OS   WR)).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10254;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2219701; DOI=10.1016/0042-6822(90)90338-r;
RA   Roseman N.A., Slabaugh M.B.;
RT   "The vaccinia virus HindIII F fragment: nucleotide sequence of the left 6.2
RT   kb.";
RL   Virology 178:410-418(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Esposito J.J., Frace A.M., Sammons S.A., Olsen-Rasmussen M., Osborne J.,
RA   Wohlhueter R.;
RT   "Sequencing of the coding region of Vaccinia-WR to an average 9-fold
RT   redundancy and an error rate of 0.16/10kb.";
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   FUNCTION.
RX   PubMed=17554022; DOI=10.1099/vir.0.82815-0;
RA   Froggatt G.C., Smith G.L., Beard P.M.;
RT   "Vaccinia virus gene F3L encodes an intracellular protein that affects the
RT   innate immune response.";
RL   J. Gen. Virol. 88:1917-1921(2007).
CC   -!- FUNCTION: Might have a role in the suppression of host immune response.
CC       {ECO:0000269|PubMed:17554022}.
CC   -!- SIMILARITY: Belongs to the poxviruses Kelch family. {ECO:0000305}.
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DR   EMBL; M34368; AAA48245.1; -; mRNA.
DR   EMBL; AY243312; AAO89321.1; -; Genomic_DNA.
DR   PIR; G36213; G36213.
DR   SMR; P24357; -.
DR   Proteomes; UP000000344; Genome.
DR   Gene3D; 2.120.10.80; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 3.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00612; Kelch; 3.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   2: Evidence at transcript level;
KW   Kelch repeat; Reference proteome; Repeat.
FT   CHAIN           1..480
FT                   /note="Kelch repeat protein F3"
FT                   /id="PRO_0000119167"
FT   DOMAIN          10..90
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          125..223
FT                   /note="BACK"
FT   REPEAT          273..319
FT                   /note="Kelch 1"
FT   REPEAT          320..363
FT                   /note="Kelch 2"
FT   REPEAT          365..408
FT                   /note="Kelch 3"
FT   REPEAT          410..447
FT                   /note="Kelch 4"
FT   REPEAT          448..480
FT                   /note="Kelch 5"
FT   CONFLICT        64
FT                   /note="W -> R (in Ref. 2; AAO89321)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   480 AA;  55805 MW;  3DC450E51EBD3CB9 CRC64;
     MPIFVNTVYC KNILALSMTK KFKTIIDAIG GNIIVNSTIL KKLSPYFRTH LRQKYTKNKD
     PVTWVCLDLD IHSLTSIVIY SYTGKVYIDS HNVVNLLRAS ILTSVEFIIY TCINFILRDF
     RKEYCVECYM MGIEYGLSNL LCHTKNFIAK HFLELEDDII DNFDYLSMKL ILESDELNVP
     DEDYVVDFVI KWYIKRRNKL GNLLLLIKNV IRSNYLSPRG INNVKWILDC TKIFHCDKQP
     RKSYKYPFIE YPMNMDQIID IFHMCTSTHV GEVVYLIGGW MNNEIHNNAI AVNYISNNWI
     PIPPMNSPRL YASGIPANNK LYVVGGLPNP TSVERWFHGD AAWVNMPSLL KPRCNPAVAS
     INNVIYVMGG HSETDTTTEY LLPNHDQWQF GPSTYYPHYK SCALVFGRRL FLVGRNAEFY
     CESSNTWTLI DDPIYPRDNP ELIIVDNKLL LIGGFYRESY IDTIEVYNHH TYSWNIWDGK