ID   F5_VACCP                Reviewed;         321 AA.
AC   Q00320;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=36 kDa major membrane protein F5;
DE   Flags: Precursor;
GN   ORFNames=F13;
OS   Vaccinia virus (strain L-IVP) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=31531;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Prikhod'Ko G.G., Cheshenko N.V., Netesova N.A., Kozhina E.N.,
RA   Totmenin A.V., Lebedeva T.V., Malygin E.G., Vasilenko S.K.;
RT   "Localization of the vaccinia virus gene coding for the major membrane
RT   protein 36k.";
RL   Dokl. Biochem. 313:497-500(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Mikryukov N.N., Chizhikov V.E., Prikhod'Ko G.G., Urmmanov I.M.,
RA   Serpinskii O.I., Blinov V.M., Nikulin A.E., Vasilenko S.K.;
RT   "Structural-functional organization of segment of vaccinia virus genome.";
RL   Biotekhnologiya 4:442-449(1988).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the poxviridae F5 protein family. {ECO:0000305}.
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DR   EMBL; X61154; CAA43468.1; -; mRNA.
DR   EMBL; M57977; AAA48293.1; -; Genomic_DNA.
DR   SMR; Q00320; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016032; P:viral process; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR007674; Poxvirus_36kDa_major_membrane.
DR   Pfam; PF04595; Pox_I6; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..321
FT                   /note="36 kDa major membrane protein F5"
FT                   /id="PRO_0000040615"
FT   TRANSMEM        286..306
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        36
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        41
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        72
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        79
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        108
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        144
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        220
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        245
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   321 AA;  36436 MW;  A3C195AEFE5F2898 CRC64;
     MGTNGVRVFV ILYLLAVCGC IEYDVDDNVH ICTHTNVSHI NHTSWYYNDK VIALATEDKT
     SGYISSFIKR VNISLTCLNI SSLRYEDSGT YKGVSHLKDG VIVTTTMNIS VKANIVDLTG
     RVRYLTRNYC EVKIRCEITS FALNGSTTPP HMILGTVDKW KYLPFPTDDY RYVGELKRYI
     SGNPYPTESL ALEISSTFNR FTIVKNLNDD EFSCYLFSQN YSFHKMLNVR NICESKWKAL
     NNNDNASSMP ASHNNLANDL SSMMSQLQND NDDNNDYSAP MNVDNLIMIV LITMLSIILV
     IIVVIAAISI YKRSKYRHID N