ID   F5_VAR67                Reviewed;         322 AA.
AC   P33865;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=36 kDa major membrane protein F5;
DE   Flags: Precursor;
GN   ORFNames=C9L, F5L;
OS   Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=587200;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=India-1967 / Isolate Ind3;
RX   PubMed=8109158; DOI=10.1016/0168-1702(93)90093-3;
RA   Shchelkunov S.N., Blinov V.M., Resenchuk S.M., Totmenin A.V.,
RA   Sandakhchiev L.S.;
RT   "Analysis of the nucleotide sequence of a 43 kbp segment of the genome of
RT   variola virus India-1967 strain.";
RL   Virus Res. 30:239-258(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=India-1967 / Isolate Ind3;
RX   PubMed=8384129; DOI=10.1016/0014-5793(93)80041-r;
RA   Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.;
RT   "Genes of variola and vaccinia viruses necessary to overcome the host
RT   protective mechanisms.";
RL   FEBS Lett. 319:80-83(1993).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the poxviridae F5 protein family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA48970.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; X69198; CAA48970.1; ALT_INIT; Genomic_DNA.
DR   PIR; I36839; I36839.
DR   RefSeq; NP_042073.2; NC_001611.1.
DR   SMR; P33865; -.
DR   GeneID; 1486389; -.
DR   KEGG; vg:1486389; -.
DR   Proteomes; UP000002060; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016032; P:viral process; IEA:InterPro.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR007674; Poxvirus_36kDa_major_membrane.
DR   Pfam; PF04595; Pox_I6; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..322
FT                   /note="36 kDa major membrane protein F5"
FT                   /id="PRO_0000040617"
FT   TRANSMEM        287..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        36
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        41
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        72
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        79
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        108
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        144
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        219
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        245
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   322 AA;  36721 MW;  142F7A33579E4F1E CRC64;
     MGTNTIRAFI ILYLLAVCGC VEYDVDNNVQ ICTCANVSHI NHTFWYYNNK VIALATEDRT
     SGYISSFIKR VNISLTCLNI SSLRYEDSGS YKGVSHLKDG VIVTTTMNIS VKANIIDLTG
     RVCYLTRNYC EVKIRCEIKS FALNGSITPL HMILGTLDRW KYLPFPTDDY RYVGELKRYI
     SGNPYPIESL ALEISATFNR FTIVKNNDDE FSCYLFSQNY SFHKMLNARH ICESEWEALN
     NNNDNSSSMP VSHNNRANDL SSMMSQLQND NDDNNDYSAP MNINNLIMIV LITMLSIIII
     IIVVIAIIAM YKRSKYSHID DN