F74A1_HUMAN
ID F74A1_HUMAN Reviewed; 127 AA.
AC Q5RGS3; A6NK17;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=Protein FAM74A1 {ECO:0000305};
GN Name=FAM74A1 {ECO:0000312|HGNC:HGNC:32029};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q5RGS3; Q02535: ID3; NbExp=3; IntAct=EBI-10244822, EBI-1387094;
CC Q5RGS3; Q8IXK0: PHC2; NbExp=3; IntAct=EBI-10244822, EBI-713786;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the FAM74 family. {ECO:0000305}.
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DR EMBL; BX664726; CAI17098.1; -; Genomic_DNA.
DR EMBL; BX005214; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL596385; CAI95395.1; -; Genomic_DNA.
DR EMBL; BC118602; -; NOT_ANNOTATED_CDS; mRNA.
DR AlphaFoldDB; Q5RGS3; -.
DR SMR; Q5RGS3; -.
DR IntAct; Q5RGS3; 2.
DR iPTMnet; Q5RGS3; -.
DR PhosphoSitePlus; Q5RGS3; -.
DR BioMuta; HGNC:32029; -.
DR PaxDb; Q5RGS3; -.
DR PRIDE; Q5RGS3; -.
DR GeneCards; FAM74A1; -.
DR HGNC; HGNC:32029; FAM74A1.
DR neXtProt; NX_Q5RGS3; -.
DR InParanoid; Q5RGS3; -.
DR PhylomeDB; Q5RGS3; -.
DR TreeFam; TF341437; -.
DR PathwayCommons; Q5RGS3; -.
DR SignaLink; Q5RGS3; -.
DR Pharos; Q5RGS3; Tdark.
DR PRO; PR:Q5RGS3; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q5RGS3; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..127
FT /note="Protein FAM74A1"
FT /id="PRO_0000266046"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..62
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 127 AA; 14779 MW; CB370FC895D5B15B CRC64;
MWRELRGCPG GDVETAQRLS QRRRGKSSEA VPEKTWRAQR MSQRRRGESS EAVPEKTWKE
LRNSETVPEK TWKQLRRCLQ EDVERVQRLS LLLHLAVFLW IIIAINFSNS GVKSQSSTYL
PSGKILK