F83DB_XENLA
ID F83DB_XENLA Reviewed; 562 AA.
AC A1L1G9;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 2.
DT 03-AUG-2022, entry version 45.
DE RecName: Full=Protein FAM83D-B {ECO:0000305};
GN Name=fam83d-b {ECO:0000250|UniProtKB:Q9H4H8};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Spleen;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May regulate cell proliferation, growth, migration and
CC epithelial to mesenchymal transition. May also be important for proper
CC chromosome congression and alignment during mitosis.
CC {ECO:0000250|UniProtKB:Q9H4H8}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9H4H8}.
CC Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9H4H8}.
CC Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q9H4H8}.
CC -!- SIMILARITY: Belongs to the FAM83 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI29057.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; BC129056; AAI29057.1; ALT_INIT; mRNA.
DR RefSeq; XP_018090691.1; XM_018235202.1.
DR AlphaFoldDB; A1L1G9; -.
DR SMR; A1L1G9; -.
DR GeneID; 495259; -.
DR KEGG; xla:495259; -.
DR CTD; 495259; -.
DR Xenbase; XB-GENE-964366; fam83d.L.
DR OMA; NSGIYDH; -.
DR OrthoDB; 433035at2759; -.
DR Proteomes; UP000186698; Chromosome 9_10L.
DR Bgee; 495259; Expressed in egg cell and 15 other tissues.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0097431; C:mitotic spindle pole; ISS:UniProtKB.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0008283; P:cell population proliferation; ISS:UniProtKB.
DR GO; GO:0051310; P:metaphase plate congression; ISS:UniProtKB.
DR GO; GO:0070372; P:regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.
DR InterPro; IPR012461; FAM83_N.
DR Pfam; PF07894; FAM83; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; Cell division; Cytoplasm; Cytoskeleton; Mitosis;
KW Reference proteome.
FT CHAIN 1..562
FT /note="Protein FAM83D-B"
FT /id="PRO_0000365011"
FT REGION 424..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 562 AA; 62364 MW; DFF7F8A1BA957604 CRC64;
MANASQCLDD VPMGGRWPAA PPDQYNEAHR LAMEELVSGG PEAMRGFLKR ERLPSFLSEP
EMGEILGCAS VLPCGDEENS MSASVDCSSV TYFPDRSDVE PPILELGWPA FTTGSYRGVT
RVDVHFQPSF GDTIYTCKEA ARELIRSARE VIALVMDNFT DNDIFRDIHE ACRKRRVPVY
ILLDQTQVSH FLTMCYNLGV SIETEPHMRV RLLTGNNYYT RSGTKIIGKV REKFLLVDGV
KVATGNYSFT WTDGKLNSSN MLVLSGQVVE KFDLQFRILY AQSNPIGAKL LSSIRSRVMC
LDKLPCKLPA SKKPTLSSLL RMDQAKLSST PKRHFDEFGA KFNRDVVALD KAAEDEWLQS
CDIISGLKEM QTVEVQTEPW EGKNNVRGVD VGIQTSVAAA NAATQTSVLS RMASTQTVMV
SRSITTQTTE TSQCTTQTPA PTSSVARLSN SSNSSSSSFS SASTTSTGSN CSMKSSDFSG
TAFYQPEYPL GNCFKKLTKD RQYHYSTIRS KLNHMVSILS NRNRVPNSYM ANDAPCYGLQ
RREIMHGSLL NLRDGVRFYP NM