F91A1_DANRE
ID F91A1_DANRE Reviewed; 831 AA.
AC Q6TEP1; Q7SYC3;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 2.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=Protein FAM91A1;
GN Name=fam91a1; ORFNames=si:dkey-5e12.2, zgc:63609;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=SJD;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 38-831.
RC TISSUE=Kidney marrow;
RX PubMed=15520368; DOI=10.1073/pnas.0407241101;
RA Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y.,
RA Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X.,
RA Look A.T., Chen Z.;
RT "Hematopoietic gene expression profile in zebrafish kidney marrow.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
CC -!- FUNCTION: As component of the WDR11 complex may act together with
CC TBC1D23 to facilitate the golgin-mediated capture of vesicles generated
CC using AP-1. {ECO:0000250|UniProtKB:Q658Y4}.
CC -!- SUBUNIT: May be a component of the WDR1 complex (By similarity). May
CC interact with golgins. {ECO:0000250|UniProtKB:Q658Y4}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network
CC {ECO:0000250|UniProtKB:Q658Y4}. Cytoplasmic vesicle
CC {ECO:0000250|UniProtKB:Q658Y4}.
CC -!- SIMILARITY: Belongs to the FAM91 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAQ97984.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BX004966; CAK11119.1; -; Genomic_DNA.
DR EMBL; BC054922; AAH54922.1; -; mRNA.
DR EMBL; AY423008; AAQ97984.1; ALT_INIT; mRNA.
DR RefSeq; NP_956735.1; NM_200441.1.
DR AlphaFoldDB; Q6TEP1; -.
DR STRING; 7955.ENSDARP00000008437; -.
DR PaxDb; Q6TEP1; -.
DR PRIDE; Q6TEP1; -.
DR Ensembl; ENSDART00000019459; ENSDARP00000008437; ENSDARG00000003320.
DR GeneID; 393413; -.
DR KEGG; dre:393413; -.
DR CTD; 157769; -.
DR ZFIN; ZDB-GENE-040426-1187; fam91a1.
DR eggNOG; KOG3707; Eukaryota.
DR GeneTree; ENSGT00390000009543; -.
DR HOGENOM; CLU_010656_0_0_1; -.
DR InParanoid; Q6TEP1; -.
DR OMA; PEHGPAN; -.
DR OrthoDB; 164905at2759; -.
DR PhylomeDB; Q6TEP1; -.
DR TreeFam; TF314641; -.
DR Reactome; R-DRE-9013407; RHOH GTPase cycle.
DR PRO; PR:Q6TEP1; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 19.
DR Bgee; ENSDARG00000003320; Expressed in brain and 19 other tissues.
DR ExpressionAtlas; Q6TEP1; baseline and differential.
DR GO; GO:0031410; C:cytoplasmic vesicle; ISS:UniProtKB.
DR GO; GO:0005802; C:trans-Golgi network; ISS:UniProtKB.
DR GO; GO:0006886; P:intracellular protein transport; ISS:UniProtKB.
DR GO; GO:0099041; P:vesicle tethering to Golgi; IBA:GO_Central.
DR InterPro; IPR039199; FAM91.
DR InterPro; IPR028097; FAM91_C_dom.
DR InterPro; IPR028091; FAM91_N_dom.
DR PANTHER; PTHR28441; PTHR28441; 1.
DR Pfam; PF14648; FAM91_C; 1.
DR Pfam; PF14647; FAM91_N; 1.
PE 2: Evidence at transcript level;
KW Cytoplasmic vesicle; Golgi apparatus; Reference proteome.
FT CHAIN 1..831
FT /note="Protein FAM91A1"
FT /id="PRO_0000282554"
FT REGION 341..362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 690..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 770..794
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..362
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 831 AA; 93048 MW; 05B849FBFC13B138 CRC64;
MNTDVEFHIR QNYPWNKLPA NVKQSLGNSQ REYDKQVLLY SIRNQLRFRN NLVRHVKKDE
RKYYEELLKY SREHLMLYPY HLSDIMVKGL RVTPFSYYIS IMEDIMNCEK SYDSLPNFTA
ADCLRLLGIG RNQYIDLMNQ CRSSKKFFRR KSARDLLPAK PVEITVEPWW VVQTGYITED
DIRICSVAEK AAIDKMIDSG PQLAGSMEYN VVLSLYNRGY IYLDVPISDD SCISVPPLEG
FVMNRVQGDY FETLLYKIFV SIDEQTNVSE LANVLEIDLG LVKNAVSMYC RLGFAIKKGQ
VISPDQLHPS WKSAPSVNRL KGTMDPQKML LSWEGGSPVM EAGSSATDTD TTSLEDQDTA
SVSSLSIPAA PTKRIAFLFD STLTAFLMMG NLSPNLKSHA VTMFEVGKLS DETLDSFLME
LEKVESTAEG EAQRYFDHAL TLRNTILFLR YNKDLTPDQG PDVPNIGLPL DLLRCESLLG
LDPATCSRVL NKNYKLLVSM APLSNEIRPI SSCTPQHIGP AIPEVSSIWF KLYLYSVTGQ
GPPSLLLSKG SRLRKLPDIF QAYDRLLITS WGHDPGVVPS SNVLTMLNDA LTHSAVLIQG
HGMHGHGETV HVPFPFDEED LKGEFSYSNM CAHKALKILR DKVDLEHQCG YITMLNHNNR
HRRRASDADG DAELCGVLDA NGSNESFELV TEENNGDGGK KQGTEASSSE DEWVPLELCF
GMPLFSSELN RKVCQRIVSH KLCSKDSLQE LLHSSRKLAL KVLSFVQSFQ DGKQPADPDS
GVSGPLSQPP AESGVPLPAI NLLFKDGELK EWSGRAPPSL HISAPQRDQP T
