F91A1_HUMAN
ID F91A1_HUMAN Reviewed; 838 AA.
AC Q658Y4; B6YY23; Q658T5; Q8TE89;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-NOV-2008, sequence version 3.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Protein FAM91A1;
GN Name=FAM91A1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT TYR-800.
RA Nicassio F., Bianchi F., Capra M., Vecchi M., Confalonieri S., Bianchi M.,
RA Pajalunga D., Crescenzi M., Bonapace I.M., Di Fiore P.P.;
RT "A cancer-specific transcriptional signature in human neoplasia.";
RL Eur. J. Clin. Invest. 115:0-0(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 144-838, AND VARIANT TYR-800.
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 336-838, AND VARIANT TYR-800.
RC TISSUE=Lymph node;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18220336; DOI=10.1021/pr0705441;
RA Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III;
RT "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient
RT phosphoproteomic analysis.";
RL J. Proteome Res. 7:1346-1351(2008).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-340, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA Greff Z., Keri G., Stemmann O., Mann M.;
RT "Kinase-selective enrichment enables quantitative phosphoproteomics of the
RT kinome across the cell cycle.";
RL Mol. Cell 31:438-448(2008).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-340 AND SER-671, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-671, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [10]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-332 AND SER-828, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [12]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-671, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [13]
RP INTERACTION WITH GOLGA1; GOLGA4 AND TBC1D23, AND SUBCELLULAR LOCATION.
RX PubMed=29084197; DOI=10.1038/ncb3627;
RA Shin J.J.H., Gillingham A.K., Begum F., Chadwick J., Munro S.;
RT "TBC1D23 is a bridging factor for endosomal vesicle capture by golgins at
RT the trans-Golgi.";
RL Nat. Cell Biol. 19:1424-1432(2017).
RN [14]
RP FUNCTION, SUBCELLULAR LOCATION, AND IDENTIFICATION IN A COMPLEX WITH
RP C17ORF75 AND WDR11.
RX PubMed=29426865; DOI=10.1038/s41467-018-02919-4;
RA Navarro Negredo P., Edgar J.R., Manna P.T., Antrobus R., Robinson M.S.;
RT "The WDR11 complex facilitates the tethering of AP-1-derived vesicles.";
RL Nat. Commun. 9:596-596(2018).
CC -!- FUNCTION: As component of the WDR11 complex acts together with TBC1D23
CC to facilitate the golgin-mediated capture of vesicles generated using
CC AP-1. {ECO:0000269|PubMed:29426865}.
CC -!- SUBUNIT: Component of the complex WDR11 composed of C17orf75, FAM91A1
CC and WDR11; FAM91A1 and WDR11 are required for proper location of the
CC complex (PubMed:29426865). Interacts with golgins GOLGA1 and GOLGA4 and
CC with TBC1D23; interaction with golgins may be mediated by TBC1D23 and
CC interaction with TBC1D23 recruits TBC1D23 to AP-1-derived vesicles
CC (PubMed:29084197, PubMed:29426865). {ECO:0000269|PubMed:29084197,
CC ECO:0000269|PubMed:29426865}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network
CC {ECO:0000269|PubMed:29084197, ECO:0000269|PubMed:29426865}. Cytoplasmic
CC vesicle {ECO:0000269|PubMed:29426865}. Note=Recruitment to the TGN
CC requires the presence of GOLGA1, GOLGA4 and TBC1D23.
CC {ECO:0000269|PubMed:29084197}.
CC -!- SIMILARITY: Belongs to the FAM91 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB85063.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; DQ228141; ABB17070.1; -; mRNA.
DR EMBL; AC011134; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK074370; BAB85063.1; ALT_INIT; mRNA.
DR EMBL; AL832830; CAH56231.1; -; mRNA.
DR EMBL; AL832999; CAH56297.1; -; mRNA.
DR CCDS; CCDS6346.2; -.
DR RefSeq; NP_001304846.1; NM_001317917.1.
DR RefSeq; NP_001304847.1; NM_001317918.1.
DR RefSeq; NP_659400.2; NM_144963.3.
DR AlphaFoldDB; Q658Y4; -.
DR BioGRID; 127622; 148.
DR IntAct; Q658Y4; 30.
DR MINT; Q658Y4; -.
DR STRING; 9606.ENSP00000335082; -.
DR iPTMnet; Q658Y4; -.
DR PhosphoSitePlus; Q658Y4; -.
DR BioMuta; FAM91A1; -.
DR DMDM; 212276508; -.
DR EPD; Q658Y4; -.
DR jPOST; Q658Y4; -.
DR MassIVE; Q658Y4; -.
DR MaxQB; Q658Y4; -.
DR PaxDb; Q658Y4; -.
DR PeptideAtlas; Q658Y4; -.
DR PRIDE; Q658Y4; -.
DR ProteomicsDB; 65930; -.
DR Antibodypedia; 27033; 122 antibodies from 18 providers.
DR DNASU; 157769; -.
DR Ensembl; ENST00000334705.12; ENSP00000335082.7; ENSG00000176853.16.
DR GeneID; 157769; -.
DR KEGG; hsa:157769; -.
DR MANE-Select; ENST00000334705.12; ENSP00000335082.7; NM_144963.4; NP_659400.3.
DR UCSC; uc003yqv.4; human.
DR CTD; 157769; -.
DR GeneCards; FAM91A1; -.
DR HGNC; HGNC:26306; FAM91A1.
DR HPA; ENSG00000176853; Low tissue specificity.
DR neXtProt; NX_Q658Y4; -.
DR OpenTargets; ENSG00000176853; -.
DR PharmGKB; PA142671820; -.
DR VEuPathDB; HostDB:ENSG00000176853; -.
DR eggNOG; KOG3707; Eukaryota.
DR GeneTree; ENSGT00390000009543; -.
DR InParanoid; Q658Y4; -.
DR OMA; PEHGPAN; -.
DR OrthoDB; 164905at2759; -.
DR PhylomeDB; Q658Y4; -.
DR TreeFam; TF314641; -.
DR PathwayCommons; Q658Y4; -.
DR Reactome; R-HSA-9013407; RHOH GTPase cycle.
DR SignaLink; Q658Y4; -.
DR BioGRID-ORCS; 157769; 141 hits in 1050 CRISPR screens.
DR ChiTaRS; FAM91A1; human.
DR GenomeRNAi; 157769; -.
DR Pharos; Q658Y4; Tbio.
DR PRO; PR:Q658Y4; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q658Y4; protein.
DR Bgee; ENSG00000176853; Expressed in ileal mucosa and 185 other tissues.
DR ExpressionAtlas; Q658Y4; baseline and differential.
DR Genevisible; Q658Y4; HS.
DR GO; GO:0031410; C:cytoplasmic vesicle; IDA:UniProtKB.
DR GO; GO:0005802; C:trans-Golgi network; IDA:UniProtKB.
DR GO; GO:0006886; P:intracellular protein transport; IDA:UniProtKB.
DR GO; GO:0099041; P:vesicle tethering to Golgi; IDA:UniProtKB.
DR InterPro; IPR039199; FAM91.
DR InterPro; IPR028097; FAM91_C_dom.
DR InterPro; IPR028091; FAM91_N_dom.
DR PANTHER; PTHR28441; PTHR28441; 1.
DR Pfam; PF14648; FAM91_C; 1.
DR Pfam; PF14647; FAM91_N; 1.
PE 1: Evidence at protein level;
KW Cytoplasmic vesicle; Golgi apparatus; Phosphoprotein; Reference proteome.
FT CHAIN 1..838
FT /note="Protein FAM91A1"
FT /id="PRO_0000282552"
FT REGION 334..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 670..690
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..367
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 332
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 340
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:18691976"
FT MOD_RES 671
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:24275569"
FT MOD_RES 828
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VARIANT 704
FT /note="I -> V (in dbSNP:rs6470187)"
FT /id="VAR_057768"
FT VARIANT 800
FT /note="C -> Y (in dbSNP:rs1946586)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:17974005, ECO:0000269|Ref.1"
FT /id="VAR_067449"
SQ SEQUENCE 838 AA; 93909 MW; 1F50F89A4BFB6B08 CRC64;
MNIDVEFHIR HNYPWNKLPA NVRQSLGNSQ REYEKQVVLY SIRNQLRYRN NLVKHVKKDE
RRYYEELLKY SRDHLMLYPY HLSDIMVKGL RITPFSYYTG IMEDIMNSEK SYDSLPNFTA
ADCLRLLGIG RNQYIDLMNQ CRSSKKFFRR KTARDLLPIK PVEIAIEAWW VVQAGYITED
DIKICTLPEK CAVDKIIDSG PQLSGSLDYN VVHSLYNKGF IYLDVPISDD SCIAVPPLEG
FVMNRVQGDY FETLLYKIFV SIDEHTNVAE LANVLEIDLS LVKNAVSMYC RLGFAHKKGQ
VINLDQLHSS WKNVPSVNRL KSTLDPQKML LSWDGGESRS PVQEASSATD TDTNSQEDPA
DTASVSSLSL STGHTKRIAF LFDSTLTAFL MMGNLSPNLK SHAVTMFEVG KLSDESLDSF
LIELEKVQST GEGEAQRYFD HALTLRNTIL FLRHNKDLVA QTAQPDQPNY GFPLDLLRCE
SLLGLDPATC SRVLNKNYTL LVSMAPLTNE IRPVSSCTPQ HIGPAIPEVS SVWFKLYIYH
VTGQGPPSLL LSKGTRLRKL PDIFQSYDRL LITSWGHDPG VVPTSNVLTM LNDALTHSAV
LIQGHGLHGI GETVHVPFPF DETELQGEFT RVNMGVHKAL QILRNRVDLQ HLCGYVTMLN
ASSQLADRKL SDASDERGEP DLASGSDVNG STESFEMVIE EATIDSATKQ TSGATTEADW
VPLELCFGIP LFSSELNRKV CRKIAAHGLC RKESLQNLLH SSRKLSLQVL NFVHSFQEGA
SILDIHTEPS FSSLLSQSSC ADMGVPLPAK NLIFKDGVLS EWSGRSPSSL LIANLHLQ
