F91A1_MOUSE
ID F91A1_MOUSE Reviewed; 837 AA.
AC Q3UVG3; Q80TZ0; Q8K077;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Protein FAM91A1;
GN Name=Fam91a1; Synonyms=D15Ertd621e, Kiaa0493;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA Nakajima D., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:35-48(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-834, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Kidney, Liver, Lung, Pancreas, Spleen,
RC and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5]
RP INTERACTION WITH TBC1D23.
RX PubMed=29084197; DOI=10.1038/ncb3627;
RA Shin J.J.H., Gillingham A.K., Begum F., Chadwick J., Munro S.;
RT "TBC1D23 is a bridging factor for endosomal vesicle capture by golgins at
RT the trans-Golgi.";
RL Nat. Cell Biol. 19:1424-1432(2017).
CC -!- FUNCTION: As component of the WDR11 complex acts together with TBC1D23
CC to facilitate the golgin-mediated capture of vesicles generated using
CC AP-1. {ECO:0000250|UniProtKB:Q658Y4}.
CC -!- SUBUNIT: Component of the complex WDR11 composed of C17orf75, FAM91A1
CC and WDR11; FAM91A1 and WDR11 are required for proper location of the
CC complex (By similarity). Interacts with golgins GOLGA1 and GOLGA4 and
CC with TBC1D23; interaction with golgins may be mediated by TBC1D23 and
CC interaction with TBC1D23 recruits TBC1D23 to AP-1-derived vesicles
CC (PubMed:29084197). {ECO:0000250|UniProtKB:Q658Y4,
CC ECO:0000269|PubMed:29084197}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network
CC {ECO:0000250|UniProtKB:Q658Y4}. Cytoplasmic vesicle
CC {ECO:0000250|UniProtKB:Q658Y4}. Note=Recruitment to the TGN requires
CC the presence of GOLGA1, GOLGA4 and TBC1D23.
CC {ECO:0000250|UniProtKB:Q658Y4}.
CC -!- SIMILARITY: Belongs to the FAM91 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH33609.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC65579.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK122297; BAC65579.1; ALT_INIT; mRNA.
DR EMBL; AK137324; BAE23306.1; -; mRNA.
DR EMBL; BC033609; AAH33609.1; ALT_INIT; mRNA.
DR EMBL; BC070426; AAH70426.1; -; mRNA.
DR CCDS; CCDS37080.1; -.
DR RefSeq; NP_666071.2; NM_145959.3.
DR AlphaFoldDB; Q3UVG3; -.
DR BioGRID; 229196; 1.
DR STRING; 10090.ENSMUSP00000036524; -.
DR iPTMnet; Q3UVG3; -.
DR PhosphoSitePlus; Q3UVG3; -.
DR EPD; Q3UVG3; -.
DR jPOST; Q3UVG3; -.
DR MaxQB; Q3UVG3; -.
DR PaxDb; Q3UVG3; -.
DR PRIDE; Q3UVG3; -.
DR ProteomicsDB; 277023; -.
DR Antibodypedia; 27033; 122 antibodies from 18 providers.
DR DNASU; 210998; -.
DR Ensembl; ENSMUST00000037270; ENSMUSP00000036524; ENSMUSG00000037119.
DR GeneID; 210998; -.
DR KEGG; mmu:210998; -.
DR UCSC; uc007vtn.2; mouse.
DR CTD; 157769; -.
DR MGI; MGI:1277178; Fam91a1.
DR VEuPathDB; HostDB:ENSMUSG00000037119; -.
DR eggNOG; KOG3707; Eukaryota.
DR GeneTree; ENSGT00390000009543; -.
DR HOGENOM; CLU_010656_0_0_1; -.
DR InParanoid; Q3UVG3; -.
DR OMA; PEHGPAN; -.
DR OrthoDB; 164905at2759; -.
DR PhylomeDB; Q3UVG3; -.
DR TreeFam; TF314641; -.
DR Reactome; R-MMU-9013407; RHOH GTPase cycle.
DR BioGRID-ORCS; 210998; 4 hits in 72 CRISPR screens.
DR ChiTaRS; Fam91a1; mouse.
DR PRO; PR:Q3UVG3; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q3UVG3; protein.
DR Bgee; ENSMUSG00000037119; Expressed in postcranial axial skeleton and 102 other tissues.
DR ExpressionAtlas; Q3UVG3; baseline and differential.
DR Genevisible; Q3UVG3; MM.
DR GO; GO:0031410; C:cytoplasmic vesicle; ISS:UniProtKB.
DR GO; GO:0005802; C:trans-Golgi network; ISS:UniProtKB.
DR GO; GO:0006886; P:intracellular protein transport; ISS:UniProtKB.
DR GO; GO:0099041; P:vesicle tethering to Golgi; ISO:MGI.
DR InterPro; IPR039199; FAM91.
DR InterPro; IPR028097; FAM91_C_dom.
DR InterPro; IPR028091; FAM91_N_dom.
DR PANTHER; PTHR28441; PTHR28441; 1.
DR Pfam; PF14648; FAM91_C; 1.
DR Pfam; PF14647; FAM91_N; 1.
PE 1: Evidence at protein level;
KW Cytoplasmic vesicle; Golgi apparatus; Phosphoprotein; Reference proteome.
FT CHAIN 1..837
FT /note="Protein FAM91A1"
FT /id="PRO_0000282553"
FT REGION 334..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 670..691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..366
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 332
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q658Y4"
FT MOD_RES 340
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q658Y4"
FT MOD_RES 671
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q658Y4"
FT MOD_RES 828
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q658Y4"
FT MOD_RES 834
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 837 AA; 93464 MW; 0381DFD8299EA427 CRC64;
MNIDVEFHIR HNYPWSKLPT NVKQSLGNSQ REYEKQVVLY SIRNQLRYRN NLVKHVKKDE
RKYYEELLKY SRDHLMLYPY HLSDIMVKGL RITPFSYYAG IMEDIMNSEK SYDSLPNFTA
ADCLRLLGIG RNQYIDLMNQ CRSSKKFFRR KTARDLLPMK PVEIAIEAWW VVQAGYITED
DIKICTFPEK GAIDKIIDSG PQLSGSLDYN VVHSLYNKGF IYLDVPISDD SCIAVPPLEG
FVMNRVQGDY FETLLYKIFV SIDEHTNVAE LANVLEIDLS LVKNAVSMYC RLGFAHKKGQ
VINLDQLHSS WKNVPSVNRL KSTLDPQKML LSWDGGESRS PVQEASSATD TDTNSQEDPA
DTASVSSLSL STGYTKRIAF LFDSTLTAFL MMGNLSPNLK SHAVTMFEVG KLSDESLDSF
LIELEKVQST GEGEAQRYFD HALTLRNTIL FLRHNKDLVA QTSQPDQPNY GFPLDLLRCE
SLLGLDPATC SRVLNKNYTL LVSMAPLTNE IRPVSSCTPQ HIGPAIPEVS SVWFKLYIYH
VTGQGPPSLL LSKGTRLRKL PDIFQGYDRL LITSWGHDPG VVPASNVLTM LNDALTHSAV
LIQGHGLHGV GETVHIPFPF DEAELQGEFT RASMGVHKAL QILRSRVDLQ HFCGYVTMLN
ASSQLASRKL SEASDERGEP DLASSSDVNG STESFEMVIE EASTDLATKP NSGATAEADW
VPLELCFGIP LFSSELNRKV CQKIATHGLC RKESLQSLLH SSRKLSLQVL NFVHSFQEGA
ATLDLHAEPG FSSVLSQSPC ADMGVPLPAK NLMFKDGVLS EWSGRSPSSL LIASLHL
