F9_VAR67
ID F9_VAR67 Reviewed; 212 AA.
AC P0DSZ3; P33869;
DT 16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT 16-OCT-2019, sequence version 1.
DT 12-AUG-2020, entry version 5.
DE RecName: Full=Protein F9;
GN ORFNames=C13L, F9L;
OS Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX NCBI_TaxID=587200;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8109158; DOI=10.1016/0168-1702(93)90093-3;
RA Shchelkunov S.N., Blinov V.M., Resenchuk S.M., Totmenin A.V.,
RA Sandakhchiev L.S.;
RT "Analysis of the nucleotide sequence of a 43 kbp segment of the genome of
RT variola virus India-1967 strain.";
RL Virus Res. 30:239-258(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8384129; DOI=10.1016/0014-5793(93)80041-r;
RA Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.;
RT "Genes of variola and vaccinia viruses necessary to overcome the host
RT protective mechanisms.";
RL FEBS Lett. 319:80-83(1993).
CC -!- SUBUNIT: Interacts with G4; this interaction involves formation of a
CC transient disulfide-bonded intermediate, allowing disulfide bond
CC transfer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Single-pass
CC membrane protein {ECO:0000305}. Note=Component of the mature virion
CC (MV) membrane. The mature virion is located in the cytoplasm of
CC infected cells and is probably released by cell lysis (By similarity).
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the chordopoxvirinae L1 protein family.
CC {ECO:0000305}.
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DR EMBL; X69198; CAA48974.1; -; Genomic_DNA.
DR PIR; D36840; D36840.
DR RefSeq; NP_042077.1; NC_001611.1.
DR SMR; P0DSZ3; -.
DR GeneID; 1486569; -.
DR KEGG; vg:1486569; -.
DR Proteomes; UP000002060; Genome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR003472; Virion_mem_poxvirus_L1.
DR Pfam; PF02442; L1R_F9L; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Viral envelope protein; Virion.
FT CHAIN 1..212
FT /note="Protein F9"
FT /id="PRO_0000448184"
FT TOPO_DOM 1..175
FT /note="Virion surface"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 197..212
FT /note="Intravirion"
FT /evidence="ECO:0000255"
SQ SEQUENCE 212 AA; 23746 MW; B7CFF526FC3EB3E0 CRC64;
MAETKEFKTL YNLFIDSYLQ KLAQHSIPTN VTCAIHIGEV IGQFKNCALR ITNKCMSNTR
LSFTLMVESF IEVISLLPEK DRRAIAEEIG IDLNDVPSAV SKLEKNCNAY AEVNNIIDIQ
KLNIGECSAP PGQHMLLQIV NTGSAGANCG LQTILKSLNK IYVPPIIENR LPYYDPWFLV
GVAIILVIFT VAICSIRRNL ALKYRYGTFL YV