ID   F9_VARV                 Reviewed;         212 AA.
AC   P0DSZ4; P33869;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   29-SEP-2021, entry version 10.
DE   RecName: Full=Protein F9;
GN   ORFNames=C13L, F9L;
OS   Variola virus.
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=10255;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Bangladesh-1975;
RX   PubMed=8264798; DOI=10.1038/366748a0;
RA   Massung R.F., Esposito J.J., Liu L.I., Qi J., Utterback T.R., Knight J.C.,
RA   Aubin L., Yuran T.E., Parsons J.M., Loparev V.N., Selivanov N.A.,
RA   Cavallaro K.F., Kerlavage A.R., Mahy B.W.J., Venter J.C.;
RT   "Potential virulence determinants in terminal regions of variola smallpox
RT   virus genome.";
RL   Nature 366:748-751(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Congo-1965, Garcia-1966, and Somalia-1977;
RA   Massung R.F., Loparev V.N., Knight J.C., Chizhikov V.E., Parsons J.M.,
RA   Totmenin A.V., Shchelkunov S.N., Esposito J.J.;
RL   Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Interacts with G4; this interaction involves formation of a
CC       transient disulfide-bonded intermediate, allowing disulfide bond
CC       transfer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Single-pass
CC       membrane protein {ECO:0000305}. Note=Component of the mature virion
CC       (MV) membrane. The mature virion is located in the cytoplasm of
CC       infected cells and is probably released by cell lysis (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae L1 protein family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L22579; AAA60781.1; -; Genomic_DNA.
DR   EMBL; U18340; AAA69444.1; -; Genomic_DNA.
DR   EMBL; U18337; AAA69338.1; -; Genomic_DNA.
DR   EMBL; U18338; AAA69379.1; -; Genomic_DNA.
DR   PIR; G72154; G72154.
DR   PIR; T28471; T28471.
DR   RefSeq; NP_042077.1; NC_001611.1.
DR   SMR; P0DSZ4; -.
DR   GeneID; 1486569; -.
DR   KEGG; vg:1486569; -.
DR   Proteomes; UP000119805; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR003472; Virion_mem_poxvirus_L1.
DR   Pfam; PF02442; L1R_F9L; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Membrane; Transmembrane; Transmembrane helix;
KW   Viral envelope protein; Virion.
FT   CHAIN           1..212
FT                   /note="Protein F9"
FT                   /id="PRO_0000448185"
FT   TOPO_DOM        1..175
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        176..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        197..212
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   212 AA;  23746 MW;  B7CFF526FC3EB3E0 CRC64;
     MAETKEFKTL YNLFIDSYLQ KLAQHSIPTN VTCAIHIGEV IGQFKNCALR ITNKCMSNTR
     LSFTLMVESF IEVISLLPEK DRRAIAEEIG IDLNDVPSAV SKLEKNCNAY AEVNNIIDIQ
     KLNIGECSAP PGQHMLLQIV NTGSAGANCG LQTILKSLNK IYVPPIIENR LPYYDPWFLV
     GVAIILVIFT VAICSIRRNL ALKYRYGTFL YV