FA13A_HUMAN
ID FA13A_HUMAN Reviewed; 1023 AA.
AC O94988; B4DLC1; Q24JP0; Q5PR21; Q8NBA3;
DT 11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Protein FAM13A;
GN Name=FAM13A; Synonyms=FAM13A1, KIAA0914;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Spleen;
RX PubMed=10048485; DOI=10.1093/dnares/5.6.355;
RA Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N.,
RA Tanaka A., Kotani H., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XII. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 5:355-364(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 526-1023 (ISOFORM 2).
RC TISSUE=Fetal brain, Ileal mucosa, and Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), AND VARIANT ILE-769.
RC TISSUE=Chondrosarcoma;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION (ISOFORM 3), AND TISSUE SPECIFICITY.
RX PubMed=15234000; DOI=10.1016/j.ygeno.2004.03.005;
RA Cohen M., Reichenstein M., Everts-van der Wind A., Heon-Lee J., Shani M.,
RA Lewin H.A., Weller J.I., Ron M., Seroussi E.;
RT "Cloning and characterization of FAM13A1--a gene near a milk protein QTL on
RT BTA6: evidence for population-wide linkage disequilibrium in Israeli
RT Holsteins.";
RL Genomics 84:374-383(2004).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-732, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA Greff Z., Keri G., Stemmann O., Mann M.;
RT "Kinase-selective enrichment enables quantitative phosphoproteomics of the
RT kinome across the cell cycle.";
RL Mol. Cell 31:438-448(2008).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=3; Synonyms=FAM13A1_v2;
CC IsoId=O94988-4; Sequence=Displayed;
CC Name=1; Synonyms=FAM13A1_v1;
CC IsoId=O94988-1; Sequence=VSP_039154, VSP_039155;
CC Name=2;
CC IsoId=O94988-3; Sequence=VSP_039154, VSP_039155, VSP_039158;
CC Name=4;
CC IsoId=O94988-5; Sequence=VSP_039153, VSP_039156;
CC Name=5;
CC IsoId=O94988-6; Sequence=VSP_039152, VSP_039157;
CC -!- TISSUE SPECIFICITY: Isoform 1 is widely expressed, with highest
CC expression in skeletal muscle, thymus, brain and lung. Isoform 3 is
CC less abundant than isoform 1 and predominantly expressed in kidney,
CC pancreas, liver, lung and thymus. {ECO:0000269|PubMed:15234000}.
CC -!- SIMILARITY: Belongs to the FAM13 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA74937.3; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC03636.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
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DR EMBL; AB020721; BAA74937.3; ALT_INIT; mRNA.
DR EMBL; AK027138; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK091328; BAC03636.1; ALT_SEQ; mRNA.
DR EMBL; AK296932; BAG59483.1; -; mRNA.
DR EMBL; AC108065; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC021183; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC086875; AAH86875.1; -; mRNA.
DR EMBL; BN000265; CAE18110.1; -; mRNA.
DR CCDS; CCDS34029.1; -. [O94988-4]
DR CCDS; CCDS43251.1; -. [O94988-1]
DR CCDS; CCDS58911.1; -. [O94988-6]
DR CCDS; CCDS58912.1; -. [O94988-5]
DR CCDS; CCDS58913.1; -. [O94988-3]
DR RefSeq; NP_001015045.1; NM_001015045.2. [O94988-1]
DR RefSeq; NP_001252507.1; NM_001265578.1. [O94988-5]
DR RefSeq; NP_001252508.1; NM_001265579.1. [O94988-3]
DR RefSeq; NP_001252509.1; NM_001265580.1. [O94988-6]
DR RefSeq; NP_055698.2; NM_014883.3. [O94988-4]
DR RefSeq; XP_011529818.1; XM_011531516.1. [O94988-4]
DR AlphaFoldDB; O94988; -.
DR SMR; O94988; -.
DR BioGRID; 115447; 27.
DR IntAct; O94988; 26.
DR MINT; O94988; -.
DR STRING; 9606.ENSP00000264344; -.
DR iPTMnet; O94988; -.
DR PhosphoSitePlus; O94988; -.
DR BioMuta; FAM13A; -.
DR EPD; O94988; -.
DR jPOST; O94988; -.
DR MassIVE; O94988; -.
DR MaxQB; O94988; -.
DR PaxDb; O94988; -.
DR PeptideAtlas; O94988; -.
DR PRIDE; O94988; -.
DR ProteomicsDB; 50613; -. [O94988-4]
DR ProteomicsDB; 50614; -. [O94988-1]
DR ProteomicsDB; 50615; -. [O94988-3]
DR ProteomicsDB; 50616; -. [O94988-5]
DR ProteomicsDB; 50617; -. [O94988-6]
DR Antibodypedia; 52083; 51 antibodies from 19 providers.
DR DNASU; 10144; -.
DR Ensembl; ENST00000264344.10; ENSP00000264344.5; ENSG00000138640.15. [O94988-4]
DR Ensembl; ENST00000395002.6; ENSP00000378450.2; ENSG00000138640.15. [O94988-3]
DR Ensembl; ENST00000503556.5; ENSP00000427189.1; ENSG00000138640.15. [O94988-5]
DR Ensembl; ENST00000508369.5; ENSP00000421562.1; ENSG00000138640.15. [O94988-1]
DR Ensembl; ENST00000513837.5; ENSP00000423252.1; ENSG00000138640.15. [O94988-6]
DR GeneID; 10144; -.
DR KEGG; hsa:10144; -.
DR MANE-Select; ENST00000264344.10; ENSP00000264344.5; NM_014883.4; NP_055698.2.
DR UCSC; uc003hsb.3; human. [O94988-4]
DR CTD; 10144; -.
DR DisGeNET; 10144; -.
DR GeneCards; FAM13A; -.
DR HGNC; HGNC:19367; FAM13A.
DR HPA; ENSG00000138640; Low tissue specificity.
DR MalaCards; FAM13A; -.
DR MIM; 613299; gene.
DR neXtProt; NX_O94988; -.
DR OpenTargets; ENSG00000138640; -.
DR Orphanet; 2032; Idiopathic pulmonary fibrosis.
DR PharmGKB; PA164719541; -.
DR VEuPathDB; HostDB:ENSG00000138640; -.
DR eggNOG; KOG4270; Eukaryota.
DR GeneTree; ENSGT00950000183033; -.
DR InParanoid; O94988; -.
DR OMA; FSWQQEN; -.
DR OrthoDB; 1026411at2759; -.
DR PhylomeDB; O94988; -.
DR TreeFam; TF328895; -.
DR PathwayCommons; O94988; -.
DR Reactome; R-HSA-8980692; RHOA GTPase cycle.
DR Reactome; R-HSA-9013149; RAC1 GTPase cycle.
DR SignaLink; O94988; -.
DR SIGNOR; O94988; -.
DR BioGRID-ORCS; 10144; 6 hits in 1079 CRISPR screens.
DR ChiTaRS; FAM13A; human.
DR GeneWiki; Family_with_sequence_similarity_13,_member_A1; -.
DR GenomeRNAi; 10144; -.
DR Pharos; O94988; Tbio.
DR PRO; PR:O94988; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; O94988; protein.
DR Bgee; ENSG00000138640; Expressed in secondary oocyte and 201 other tissues.
DR ExpressionAtlas; O94988; baseline and differential.
DR Genevisible; O94988; HS.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005096; F:GTPase activator activity; TAS:Reactome.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.555.10; -; 1.
DR InterPro; IPR039102; FAM13.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR15904; PTHR15904; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; SSF48350; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; GTPase activation; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..1023
FT /note="Protein FAM13A"
FT /id="PRO_0000058920"
FT DOMAIN 43..231
FT /note="Rho-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT REGION 269..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 459..562
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 628..663
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 726..759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 666..730
FT /evidence="ECO:0000255"
FT COILED 946..978
FT /evidence="ECO:0000255"
FT COMPBIAS 381..406
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 407..427
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 459..477
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 478..495
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..524
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 526..562
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 631..651
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 345
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BGI4"
FT MOD_RES 597
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BGI4"
FT MOD_RES 617
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BGI4"
FT MOD_RES 727
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BGI4"
FT MOD_RES 732
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:18691976"
FT VAR_SEQ 1..354
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_039152"
FT VAR_SEQ 1..340
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_039153"
FT VAR_SEQ 1..326
FT /note="Missing (in isoform 1 and isoform 2)"
FT /evidence="ECO:0000303|PubMed:10048485,
FT ECO:0000303|PubMed:14702039"
FT /id="VSP_039154"
FT VAR_SEQ 327..335
FT /note="GAISAKLVP -> MACEIMPLQ (in isoform 1 and isoform 2)"
FT /evidence="ECO:0000303|PubMed:10048485,
FT ECO:0000303|PubMed:14702039"
FT /id="VSP_039155"
FT VAR_SEQ 341..349
FT /note="ERPLSPFYL -> MACEIMPLQ (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_039156"
FT VAR_SEQ 355..364
FT /note="QVSNVSATGE -> MACEIMPLQR (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_039157"
FT VAR_SEQ 855..882
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10048485,
FT ECO:0000303|PubMed:14702039"
FT /id="VSP_039158"
FT VARIANT 769
FT /note="V -> I (in dbSNP:rs7657817)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_049019"
FT CONFLICT 509
FT /note="S -> T (in Ref. 2; AK027138)"
FT /evidence="ECO:0000305"
FT CONFLICT 740
FT /note="N -> Y (in Ref. 2; BAG59483)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1023 AA; 116932 MW; 767AC5A8EC862D68 CRC64;
MGAGALAICQ SKAAVRLKED MKKIVAVPLN EQKDFTYQKL FGVSLQELER QGLTENGIPA
VVWNIVEYLT QHGLTQEGLF RVNGNVKVVE QLRLKFESGV PVELGKDGDV CSAASLLKLF
LRELPDSLIT SALQPRFIQL FQDGRNDVQE SSLRDLIKEL PDTHYCLLKY LCQFLTKVAK
HHVQNRMNVH NLATVFGPNC FHVPPGLEGM KEQDLCNKIM AKILENYNTL FEVEYTENDH
LRCENLARLI IVKEVYYKNS LPILLTRGLE RDMPKPPPKT KIPKSRSEGS IQAHRVLQPE
LSDGIPQLSL RLSYRKACLE DMNSAEGAIS AKLVPSSQED ERPLSPFYLS AHVPQVSNVS
ATGELLERTI RSAVEQHLFD VNNSGGQSSE DSESGTLSAS SATSARQRRR QSKEQDEVRH
GRDKGLINKE NTPSGFNHLD DCILNTQEVE KVHKNTFGCA GERSKPKRQK SSTKLSELHD
NQDGLVNMES LNSTRSHERT GPDDFEWMSD ERKGNEKDGG HTQHFESPTM KIQEHPSLSD
TKQQRNQDAG DQEESFVSEV PQSDLTALCD EKNWEEPIPA FSSWQRENSD SDEAHLSPQA
GRLIRQLLDE DSDPMLSPRF YAYGQSRQYL DDTEVPPSPP NSHSFMRRRS SSLGSYDDEQ
EDLTPAQLTR RIQSLKKKIR KFEDRFEEEK KYRPSHSDKA ANPEVLKWTN DLAKFRRQLK
ESKLKISEED LTPRMRQRSN TLPKSFGSQL EKEDEKKQEL VDKAIKPSVE ATLESIQRKL
QEKRAESSRP EDIKDMTKDQ IANEKVALQK ALLYYESIHG RPVTKNERQV MKPLYDRYRL
VKQILSRANT IPIIGSPSSK RRSPLLQPII EGETASFFKE IKEEEEGSED DSNVKPDFMV
TLKTDFSARC FLDQFEDDAD GFISPMDDKI PSKCSQDTGL SNLHAASIPE LLEHLQEMRE
EKKRIRKKLR DFEDNFFRQN GRNVQKEDRT PMAEEYSEYK HIKAKLRLLE VLISKRDTDS
KSM
