FA13A_MOUSE
ID FA13A_MOUSE Reviewed; 693 AA.
AC Q8BGI4; Q8BZ91;
DT 11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Protein FAM13A;
DE AltName: Full=Precm1 protein;
GN Name=Fam13a; Synonyms=Fam13a1, Precm1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=FVB/N;
RX PubMed=15234000; DOI=10.1016/j.ygeno.2004.03.005;
RA Cohen M., Reichenstein M., Everts-van der Wind A., Heon-Lee J., Shani M.,
RA Lewin H.A., Weller J.I., Ron M., Seroussi E.;
RT "Cloning and characterization of FAM13A1--a gene near a milk protein QTL on
RT BTA6: evidence for population-wide linkage disequilibrium in Israeli
RT Holsteins.";
RL Genomics 84:374-383(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19; SER-267; SER-287 AND
RP SER-397, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Kidney, Lung, and Pancreas;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- TISSUE SPECIFICITY: Expressed in the mammary gland, with similar levels
CC at all stages of development, including pregnancy, lactation and
CC involution. {ECO:0000269|PubMed:15234000}.
CC -!- SIMILARITY: Belongs to the FAM13 family. {ECO:0000305}.
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DR EMBL; AJ510136; CAD52865.1; -; mRNA.
DR EMBL; AK036291; BAC29374.1; -; mRNA.
DR EMBL; AK052421; BAC34983.1; -; mRNA.
DR EMBL; BC080861; AAH80861.1; -; mRNA.
DR CCDS; CCDS39499.1; -.
DR RefSeq; NP_705802.1; NM_153574.2.
DR AlphaFoldDB; Q8BGI4; -.
DR SMR; Q8BGI4; -.
DR STRING; 10090.ENSMUSP00000087304; -.
DR iPTMnet; Q8BGI4; -.
DR PhosphoSitePlus; Q8BGI4; -.
DR jPOST; Q8BGI4; -.
DR MaxQB; Q8BGI4; -.
DR PaxDb; Q8BGI4; -.
DR PRIDE; Q8BGI4; -.
DR ProteomicsDB; 275578; -.
DR Antibodypedia; 52083; 51 antibodies from 19 providers.
DR Ensembl; ENSMUST00000089860; ENSMUSP00000087304; ENSMUSG00000037709.
DR GeneID; 58909; -.
DR KEGG; mmu:58909; -.
DR UCSC; uc009cdi.1; mouse.
DR CTD; 10144; -.
DR MGI; MGI:1889842; Fam13a.
DR VEuPathDB; HostDB:ENSMUSG00000037709; -.
DR eggNOG; KOG4270; Eukaryota.
DR GeneTree; ENSGT00950000183033; -.
DR HOGENOM; CLU_012606_1_0_1; -.
DR InParanoid; Q8BGI4; -.
DR OMA; FSWQQEN; -.
DR OrthoDB; 1026411at2759; -.
DR PhylomeDB; Q8BGI4; -.
DR TreeFam; TF328895; -.
DR Reactome; R-MMU-8980692; RHOA GTPase cycle.
DR Reactome; R-MMU-9013149; RAC1 GTPase cycle.
DR BioGRID-ORCS; 58909; 0 hits in 70 CRISPR screens.
DR ChiTaRS; Fam13a; mouse.
DR PRO; PR:Q8BGI4; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q8BGI4; protein.
DR Bgee; ENSMUSG00000037709; Expressed in pigmented layer of retina and 207 other tissues.
DR ExpressionAtlas; Q8BGI4; baseline and differential.
DR Genevisible; Q8BGI4; MM.
DR InterPro; IPR039102; FAM13.
DR PANTHER; PTHR15904; PTHR15904; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..693
FT /note="Protein FAM13A"
FT /id="PRO_0000058921"
FT REGION 56..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 136..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 302..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 396..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..81
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..150
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..201
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 302..321
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 19
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 267
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 287
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 397
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 402
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:O94988"
SQ SEQUENCE 693 AA; 79424 MW; 9636CD48CA118DC2 CRC64;
MACEIMPLRS SQEDERPLSP FYLSAHVSQV SNVSTTGELL ERTIRSAVEE HLFDVSNAGD
QSSEDSEPGP SSASSIPTRQ RGHQFKKQDD VWHGCDKELI NKENIPSGFS GCAECILNSQ
EAERFQDDIC DYVGERSKPK RQKSSSRLAK LSDNHDGALS MESLSSMQSQ ETLEPEAAEP
LSSESKEIER GGRDTQHCEN PTMKIQEHPS LSDTKQQRNQ DGEDQQESFV PDMPQLDLTA
LCDEKTWEEP IPSWQPENAD SDEARLSPQA GRLIHQFLDE DSDPMLSPRF YAYGQSRQYL
DDTEVPPSPP NSHSFMRRRS SSLGSYDDEQ EDLTPVQLTR RIQTLKKKIR KFEDRFEEER
KYRPSHSDKA ANPEVLKWTN DLAKFRKQLK ESKLKISEED LTPRTRQRSN TLPKSFGSQL
EKEDEKKQEL LDKAIRPSVE ATLEGILRKL QEKRVESSRP EDIKDMTKDQ IANEKVALQK
ALLYYESIHG RPVTKTERQI MKPLYDRYRL VKQILSRAST VPIIGSPSSK RRSPSLQPII
EGETASFFKE IKEQEEGSED DSSTKPDFAV TLKTDCSAHC FLDQLEDDAD GFISPMDDKM
PSKCSQDSGL SNLHSASIPE LLEYLQEMRE EKKMIRKKLH DFEDNFFRQN GRNVQKEDRT
PMAEEYNEYK HIKAKLRLLE VLISKRDSDS KSM
