ID   FA13B_MOUSE             Reviewed;         851 AA.
AC   Q8K2H3;
DT   11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Protein FAM13B;
GN   Name=Fam13b; Synonyms=Fam13b1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SIMILARITY: Belongs to the FAM13 family. {ECO:0000305}.
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DR   EMBL; BC031465; AAH31465.1; -; mRNA.
DR   CCDS; CCDS29128.1; -.
DR   RefSeq; NP_666196.1; NM_146084.1.
DR   AlphaFoldDB; Q8K2H3; -.
DR   SMR; Q8K2H3; -.
DR   BioGRID; 230386; 1.
DR   STRING; 10090.ENSMUSP00000038199; -.
DR   iPTMnet; Q8K2H3; -.
DR   PhosphoSitePlus; Q8K2H3; -.
DR   EPD; Q8K2H3; -.
DR   MaxQB; Q8K2H3; -.
DR   PaxDb; Q8K2H3; -.
DR   PeptideAtlas; Q8K2H3; -.
DR   PRIDE; Q8K2H3; -.
DR   ProteomicsDB; 277025; -.
DR   Antibodypedia; 26554; 99 antibodies from 17 providers.
DR   DNASU; 225358; -.
DR   Ensembl; ENSMUST00000040506; ENSMUSP00000038199; ENSMUSG00000036501.
DR   GeneID; 225358; -.
DR   KEGG; mmu:225358; -.
DR   UCSC; uc008eko.1; mouse.
DR   CTD; 51306; -.
DR   MGI; MGI:2447834; Fam13b.
DR   VEuPathDB; HostDB:ENSMUSG00000036501; -.
DR   eggNOG; KOG4270; Eukaryota.
DR   GeneTree; ENSGT00950000183033; -.
DR   HOGENOM; CLU_012606_1_0_1; -.
DR   InParanoid; Q8K2H3; -.
DR   OMA; SGEQAFH; -.
DR   OrthoDB; 1026411at2759; -.
DR   PhylomeDB; Q8K2H3; -.
DR   TreeFam; TF328895; -.
DR   Reactome; R-MMU-9013148; CDC42 GTPase cycle.
DR   Reactome; R-MMU-9013149; RAC1 GTPase cycle.
DR   BioGRID-ORCS; 225358; 2 hits in 71 CRISPR screens.
DR   ChiTaRS; Fam13b; mouse.
DR   PRO; PR:Q8K2H3; -.
DR   Proteomes; UP000000589; Chromosome 18.
DR   RNAct; Q8K2H3; protein.
DR   Bgee; ENSMUSG00000036501; Expressed in ureter smooth muscle and 249 other tissues.
DR   ExpressionAtlas; Q8K2H3; baseline and differential.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.555.10; -; 1.
DR   InterPro; IPR039102; FAM13.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   PANTHER; PTHR15904; PTHR15904; 2.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   1: Evidence at protein level;
KW   GTPase activation; Reference proteome.
FT   CHAIN           1..851
FT                   /note="Protein FAM13B"
FT                   /id="PRO_0000058925"
FT   DOMAIN          23..212
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT   REGION          556..611
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        569..584
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        586..611
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   851 AA;  97054 MW;  C2B26669FB6DB2CE CRC64;
     MRKSSSPSLS NCNSDLASKI FGIPLDELQQ GGHPDNEVPF IVRHVVDYIE EHGGLEQQGL
     FQVNGNAETV EWLRQRYDSG EEVDLVKEAD VPSAISLLRF FLQELPEPVI PGSLHIHLLQ
     LSQDYNNEDE FGRKLRFLLQ QLPPVNYSLL KFLCRFLANV ASHHEEIWSA NSLAAVFGPD
     VFHIYTDVED MKEQEIVSRI MAGLLENYYE FFENEEEDFS SNDLSSITEQ VNELSEEEEE
     DEKLEHIEEL PEEGVEKSAG MPEVLQLRMT ENLLDSDSVT ASTRIDAAAA TTTNASDGNI
     KCSKPVAGTT ADNEVMQQDF VFEDQKNNES VGILLEPCSD HGDSEDGCPE RKEYLLCDSD
     KLPHLILDSS SKIRDLNANT ELEVTEGQSV GVQGEAACIQ IAQLDLKNVS DGDKWEEPFP
     AFKSWQEDCE SGEAQLSPQA ARMTHHPLGE DCPPVLSHRS LDFGQSQRFL HDPEALDFSS
     KALSFTRIRR SSFSSKDEKR EDRTPYQLVK KLQKKIRQFE EQFERERNSK PSYSDIAANP
     KVLKWMTELT KLRKQIKDAK HKNSDGEFAP QTRPRSNTLP KSFGSSLDHE DGESEGEPRV
     IQKEKTPSKE ATLELITKRL KENRAERHLP EDIKKMTKDH LIEEKTSLQK SLLYYESQHG
     RPVTREERHI VKPLYDRYRL VKQMLTRASI TPVLGSPSTK RRGQMLQPII EGETAHFFEE
     IKEEEEDGVS LSSELGDILS TSVHTQSSLE NLESDAEENQ EKLARDLCLS STRAASVPEL
     LEQLWKARAE KKKLRKMLRE FEEAFYQQNG RNAQKEDRVP VLEEYKEYKR IKAKLRLLEV
     LISKQDSSKS I