FA13C_MOUSE
ID FA13C_MOUSE Reviewed; 601 AA.
AC Q9DBR2; D3YTZ3;
DT 11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Protein FAM13C;
GN Name=Fam13c; Synonyms=Fam13c1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130 AND SER-258, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-405 AND SER-406, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the FAM13 family. {ECO:0000305}.
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DR EMBL; AK004797; BAB23571.1; -; mRNA.
DR EMBL; AC079681; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC122896; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466553; EDL31976.1; -; Genomic_DNA.
DR CCDS; CCDS35932.1; -.
DR RefSeq; NP_077206.3; NM_024244.4.
DR AlphaFoldDB; Q9DBR2; -.
DR SMR; Q9DBR2; -.
DR STRING; 10090.ENSMUSP00000051375; -.
DR iPTMnet; Q9DBR2; -.
DR PhosphoSitePlus; Q9DBR2; -.
DR MaxQB; Q9DBR2; -.
DR PaxDb; Q9DBR2; -.
DR PRIDE; Q9DBR2; -.
DR ProteomicsDB; 275579; -.
DR Antibodypedia; 28120; 74 antibodies from 16 providers.
DR DNASU; 71721; -.
DR Ensembl; ENSMUST00000062883; ENSMUSP00000051375; ENSMUSG00000043259.
DR GeneID; 71721; -.
DR KEGG; mmu:71721; -.
DR UCSC; uc007fnx.2; mouse.
DR CTD; 220965; -.
DR MGI; MGI:1918971; Fam13c.
DR VEuPathDB; HostDB:ENSMUSG00000043259; -.
DR eggNOG; ENOG502QWSB; Eukaryota.
DR GeneTree; ENSGT00950000183033; -.
DR InParanoid; Q9DBR2; -.
DR OMA; TWLMFSC; -.
DR OrthoDB; 1026411at2759; -.
DR PhylomeDB; Q9DBR2; -.
DR TreeFam; TF328895; -.
DR BioGRID-ORCS; 71721; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Fam13c; mouse.
DR PRO; PR:Q9DBR2; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q9DBR2; protein.
DR Bgee; ENSMUSG00000043259; Expressed in lateral septal nucleus and 242 other tissues.
DR ExpressionAtlas; Q9DBR2; baseline and differential.
DR Genevisible; Q9DBR2; MM.
DR InterPro; IPR039102; FAM13.
DR PANTHER; PTHR15904; PTHR15904; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..601
FT /note="Protein FAM13C"
FT /id="PRO_0000058923"
FT REGION 82..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 192..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 268..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 327..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 366..485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..108
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..134
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 327..341
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..442
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 130
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19144319"
FT MOD_RES 258
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19144319"
FT MOD_RES 405
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 406
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 599
FT /note="K -> Q (in Ref. 1; BAB23571)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 601 AA; 66981 MW; AB1CB82F04322BDD CRC64;
MFSCFCFSLQ DNSFGSAAVT ECDEDTVSVH EDEDDCSGLR DEDNKENYPQ VAARLDELAL
PSHEAQQHVE QTLPVDGVLR TSMGNFKSRK PKSILRAESG RNHGESQETE HVVPSQSECQ
GRAGTPAHES PQSSIFRCQE TVRLQPRIDQ RATIWPKDAF GTQQDLHENS LLKLQALESG
LCSAFLTTQE EDGQVHGVKD PAPASTQSAP ADSADPADPM PAHKDAPGDA DGTSEDLQSA
GTSRLLYHIT DGDNPLLSPR CSIFSQSQRF NLDPESAPSP PSSQQFMMPR SSSRCGSGDG
KEPQTITQLT KHIQSLKRKI RKFEEKFEQE KKYRPSHGDK TSNPEVLKWM NDLAKGRKQL
KELKLKLSEE QGSTPKGPRR NLSCEQPPVP RENGKSEAVG PEPGSSGEET SDAVVPEKRE
QTPPQDDGKG TKQDKNLIKP LYDRCRGIKQ ILPTPSLIPT IQEEEDSDED CPQGSQQPSL
PDPVSRLPVG DHLIYSETEP VRTLLPDEKK EGKQPALSMS NLHEATMPVL LDHLRETRAD
KKRLRKALRE FEEQFFKQTG RSPQKEDRMP MADEYCEYKH IKAKLRLLEV LISKQDVAKT
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