FA209_MOUSE
ID FA209_MOUSE Reviewed; 170 AA.
AC A2APA5; Q9D9T2;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Protein FAM209;
DE Flags: Precursor;
GN Name=Fam209 {ECO:0000312|MGI:MGI:1923676};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP TISSUE SPECIFICITY, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH
RP DPY19L2, AND DEVELOPMENTAL STAGE.
RX PubMed=34471926; DOI=10.1242/jcs.259206;
RA Castaneda J.M., Shimada K., Satouh Y., Yu Z., Devlin D.J., Ikawa M.,
RA Matzuk M.M.;
RT "FAM209 associates with DPY19L2, and is required for sperm acrosome
RT biogenesis and fertility in mice.";
RL J. Cell Sci. 134:0-0(2021).
CC -!- FUNCTION: Required for sperm acrosome biogenesis.
CC {ECO:0000269|PubMed:34471926}.
CC -!- SUBUNIT: Interacts with DPY19L2. {ECO:0000269|PubMed:34471926}.
CC -!- SUBCELLULAR LOCATION: Nucleus inner membrane
CC {ECO:0000269|PubMed:34471926}; Single-pass type I membrane protein
CC {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Predominately expressed in testis.
CC {ECO:0000269|PubMed:34471926}.
CC -!- DEVELOPMENTAL STAGE: Detectable at postnatal day 20 when round
CC spermatids begin to appear. {ECO:0000269|PubMed:34471926}.
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DR EMBL; AK006503; BAB24622.1; -; mRNA.
DR EMBL; GL456092; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC137932; AAI37933.1; -; mRNA.
DR EMBL; BC137933; AAI37934.1; -; mRNA.
DR CCDS; CCDS50809.1; -.
DR RefSeq; NP_083884.1; NM_029608.1.
DR AlphaFoldDB; A2APA5; -.
DR STRING; 10090.ENSMUSP00000029007; -.
DR PhosphoSitePlus; A2APA5; -.
DR PaxDb; A2APA5; -.
DR PRIDE; A2APA5; -.
DR ProteomicsDB; 330737; -.
DR Ensembl; ENSMUST00000029007; ENSMUSP00000029007; ENSMUSG00000027505.
DR GeneID; 76426; -.
DR KEGG; mmu:76426; -.
DR UCSC; uc008ocy.2; mouse.
DR CTD; 76426; -.
DR MGI; MGI:1923676; Fam209.
DR VEuPathDB; HostDB:ENSMUSG00000027505; -.
DR eggNOG; ENOG502SQY6; Eukaryota.
DR GeneTree; ENSGT00390000005057; -.
DR HOGENOM; CLU_1585866_0_0_1; -.
DR InParanoid; A2APA5; -.
DR OMA; KWLWLFF; -.
DR OrthoDB; 1258912at2759; -.
DR PhylomeDB; A2APA5; -.
DR TreeFam; TF338191; -.
DR BioGRID-ORCS; 76426; 6 hits in 73 CRISPR screens.
DR ChiTaRS; Fam209; mouse.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; A2APA5; protein.
DR Bgee; ENSMUSG00000027505; Expressed in spermatid and 23 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005637; C:nuclear inner membrane; IDA:UniProtKB.
DR GO; GO:0001675; P:acrosome assembly; IMP:UniProtKB.
DR GO; GO:0007286; P:spermatid development; IMP:UniProtKB.
DR InterPro; IPR027943; FAM209.
DR PANTHER; PTHR35157; PTHR35157; 1.
DR Pfam; PF15206; FAM209; 1.
PE 1: Evidence at protein level;
KW Differentiation; Membrane; Nucleus; Reference proteome; Signal;
KW Spermatogenesis; Transmembrane; Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..170
FT /note="Protein FAM209"
FT /id="PRO_5015086030"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 83..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 4..8
FT /note="LLRWC -> QLKWR (in Ref. 1; BAB24622)"
FT /evidence="ECO:0000305"
FT CONFLICT 14..16
FT /note="CVS -> GKL (in Ref. 1; BAB24622)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 170 AA; 19554 MW; 085695CF3C588D0A CRC64;
MRTLLRWCLF LSLCVSCACA FMFSSMREKT KESPGKVPCG GHFRIRQNLP ENAQGWLGNK
WLWLFVAIMI YVMLKFRGDG ENKEQHPPGL RGCQLRSPPK KAQNISPSKD FTFNTLTQLE
MELVKFVSKV RNLKVSMATN SNSRQQVPES PTNLYNNVTI YEIWGEEDSE
