FA24B_HUMAN
ID FA24B_HUMAN Reviewed; 94 AA.
AC Q8N5W8; Q5JPG1;
DT 15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Protein FAM24B;
DE Flags: Precursor;
GN Name=FAM24B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lymph node;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-2.
RC TISSUE=Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8N5W8; P58418: CLRN1; NbExp=3; IntAct=EBI-13383724, EBI-17274839;
CC Q8N5W8; A8MZ59: LEUTX; NbExp=3; IntAct=EBI-13383724, EBI-17490413;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the FAM24 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL832795; CAI46166.1; -; Transcribed_RNA.
DR EMBL; CH471066; EAW49301.1; -; Genomic_DNA.
DR EMBL; BC031343; AAH31343.1; -; mRNA.
DR CCDS; CCDS31303.1; -.
DR RefSeq; NP_001191293.1; NM_001204364.1.
DR RefSeq; NP_689857.2; NM_152644.2.
DR AlphaFoldDB; Q8N5W8; -.
DR SMR; Q8N5W8; -.
DR BioGRID; 128226; 60.
DR IntAct; Q8N5W8; 2.
DR STRING; 9606.ENSP00000357894; -.
DR iPTMnet; Q8N5W8; -.
DR PhosphoSitePlus; Q8N5W8; -.
DR BioMuta; FAM24B; -.
DR DMDM; 166897968; -.
DR MassIVE; Q8N5W8; -.
DR PaxDb; Q8N5W8; -.
DR PeptideAtlas; Q8N5W8; -.
DR PRIDE; Q8N5W8; -.
DR ProteomicsDB; 72103; -.
DR Antibodypedia; 62636; 23 antibodies from 10 providers.
DR DNASU; 196792; -.
DR Ensembl; ENST00000368896.1; ENSP00000357892.1; ENSG00000213185.7.
DR Ensembl; ENST00000368898.8; ENSP00000357894.3; ENSG00000213185.7.
DR GeneID; 196792; -.
DR KEGG; hsa:196792; -.
DR MANE-Select; ENST00000368898.8; ENSP00000357894.3; NM_152644.3; NP_689857.2.
DR UCSC; uc001lgt.4; human.
DR CTD; 196792; -.
DR DisGeNET; 196792; -.
DR GeneCards; FAM24B; -.
DR HGNC; HGNC:23475; FAM24B.
DR HPA; ENSG00000213185; Tissue enhanced (kidney).
DR neXtProt; NX_Q8N5W8; -.
DR OpenTargets; ENSG00000213185; -.
DR PharmGKB; PA134880209; -.
DR VEuPathDB; HostDB:ENSG00000213185; -.
DR eggNOG; ENOG502TEP5; Eukaryota.
DR GeneTree; ENSGT00940000163005; -.
DR HOGENOM; CLU_160106_0_0_1; -.
DR InParanoid; Q8N5W8; -.
DR OMA; YPNLQCC; -.
DR OrthoDB; 1629398at2759; -.
DR PhylomeDB; Q8N5W8; -.
DR TreeFam; TF338384; -.
DR PathwayCommons; Q8N5W8; -.
DR SignaLink; Q8N5W8; -.
DR BioGRID-ORCS; 196792; 11 hits in 1022 CRISPR screens.
DR GenomeRNAi; 196792; -.
DR Pharos; Q8N5W8; Tdark.
DR PRO; PR:Q8N5W8; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q8N5W8; protein.
DR Bgee; ENSG00000213185; Expressed in oocyte and 148 other tissues.
DR Genevisible; Q8N5W8; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR028122; FAM24.
DR PANTHER; PTHR35860; PTHR35860; 1.
DR Pfam; PF15193; FAM24; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..94
FT /note="Protein FAM24B"
FT /id="PRO_0000021224"
FT VARIANT 2
FT /note="P -> L (in dbSNP:rs1891110)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_038485"
SQ SEQUENCE 94 AA; 10147 MW; B9A66C5BB98FBDFE CRC64;
MPVIAGGILA ALLLLIVVVL CLYFKIHNAL KAAKEPEAVA VKNHNPDKVW WAKNSQAKTI
ATESCPALQC CEGYRMCASF DSLPPCCCDI NEGL
