FA32A_MOUSE
ID FA32A_MOUSE Reviewed; 112 AA.
AC Q9CR80; Q8K5E4;
DT 07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Protein FAM32A;
DE AltName: Full=Ovarian tumor associated gene 12;
DE Short=OTAG-12;
GN Name=Fam32a; Synonyms=Otag12; ORFNames=MNCb-3154;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RA Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.;
RT "Isolation of full-length cDNA clones from mouse brain cDNA library made by
RT oligo-capping method.";
RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone marrow, Embryo, Liver, and Small intestine;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=21339736; DOI=10.1038/onc.2011.11;
RA Chen X., Zhang H., Aravindakshan J.P., Gotlieb W.H., Sairam M.R.;
RT "Anti-proliferative and pro-apoptotic actions of a novel human and mouse
RT ovarian tumor-associated gene OTAG-12: downregulation, alternative splicing
RT and drug sensitization.";
RL Oncogene 30:2874-2887(2011).
CC -!- FUNCTION: May induce G2 arrest and apoptosis (By similarity). May also
CC increase cell sensitivity to apoptotic stimuli (By similarity). In cell
CC lines, may play a role in the inhibition of anchor-independent cell
CC growth. {ECO:0000250, ECO:0000269|PubMed:21339736}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Widely expressed, with highest level in pancreas
CC and lowest in muscle. {ECO:0000269|PubMed:21339736}.
CC -!- SIMILARITY: Belongs to the FAM32 family. {ECO:0000305}.
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DR EMBL; AB041658; BAB93548.1; -; mRNA.
DR EMBL; AK008285; BAB25576.1; -; mRNA.
DR EMBL; AK011922; BAB27918.1; -; mRNA.
DR EMBL; AK075976; BAC36089.1; -; mRNA.
DR EMBL; AK082792; BAC38622.1; -; mRNA.
DR EMBL; AK150416; BAE29540.1; -; mRNA.
DR EMBL; BC006058; AAH06058.1; -; mRNA.
DR CCDS; CCDS52595.1; -.
DR RefSeq; NP_080731.1; NM_026455.4.
DR AlphaFoldDB; Q9CR80; -.
DR SMR; Q9CR80; -.
DR BioGRID; 212536; 1.
DR IntAct; Q9CR80; 3.
DR MINT; Q9CR80; -.
DR STRING; 10090.ENSMUSP00000003123; -.
DR iPTMnet; Q9CR80; -.
DR PhosphoSitePlus; Q9CR80; -.
DR EPD; Q9CR80; -.
DR MaxQB; Q9CR80; -.
DR PaxDb; Q9CR80; -.
DR PeptideAtlas; Q9CR80; -.
DR PRIDE; Q9CR80; -.
DR ProteomicsDB; 266821; -.
DR Antibodypedia; 54347; 53 antibodies from 15 providers.
DR DNASU; 67922; -.
DR Ensembl; ENSMUST00000003123; ENSMUSP00000003123; ENSMUSG00000003039.
DR GeneID; 67922; -.
DR KEGG; mmu:67922; -.
DR UCSC; uc009mfn.1; mouse.
DR CTD; 26017; -.
DR MGI; MGI:1915172; Fam32a.
DR VEuPathDB; HostDB:ENSMUSG00000003039; -.
DR eggNOG; KOG3410; Eukaryota.
DR GeneTree; ENSGT00390000013811; -.
DR HOGENOM; CLU_098435_3_0_1; -.
DR InParanoid; Q9CR80; -.
DR OMA; ENLSEHY; -.
DR OrthoDB; 1603617at2759; -.
DR PhylomeDB; Q9CR80; -.
DR TreeFam; TF314020; -.
DR BioGRID-ORCS; 67922; 23 hits in 72 CRISPR screens.
DR ChiTaRS; Fam32a; mouse.
DR PRO; PR:Q9CR80; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q9CR80; protein.
DR Bgee; ENSMUSG00000003039; Expressed in indifferent gonad and 259 other tissues.
DR Genevisible; Q9CR80; MM.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR InterPro; IPR013865; FAM32A.
DR PANTHER; PTHR13282; PTHR13282; 1.
DR Pfam; PF08555; FAM32A; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; Cell cycle; Nucleus; Reference proteome.
FT CHAIN 1..112
FT /note="Protein FAM32A"
FT /id="PRO_0000223251"
FT REGION 23..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..56
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 12
FT /note="L -> P (in Ref. 1; BAB93548)"
FT /evidence="ECO:0000305"
FT CONFLICT 37
FT /note="M -> V (in Ref. 1; BAB93548)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 112 AA; 13215 MW; 14CEF0C40B3DAD48 CRC64;
MEAYEQVQKG PLKLKGVAEL GVTKRKKKKK DKDKAKMLEA MGTSKKSEEE KRRCLDKRTP
AQAAFEKMQE KRQMERILKK ASKTHKQRVE DFNRHLDTLT EHYDIPKVSW TK
