FA43A_HUMAN
ID FA43A_HUMAN Reviewed; 423 AA.
AC Q8N2R8; A3KME2; Q8IXP4; Q8WZ07;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 2.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Protein FAM43A;
GN Name=FAM43A; ORFNames=PP7298;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15498874; DOI=10.1073/pnas.0404089101;
RA Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X.,
RA Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.,
RA Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.;
RT "Large-scale cDNA transfection screening for genes related to cancer
RT development and progression.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye, and Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8N2R8; Q6P1K8: GTF2H2C_2; NbExp=3; IntAct=EBI-18138055, EBI-8469755;
CC -!- SIMILARITY: Belongs to the FAM43 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL55769.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF289585; AAL55769.1; ALT_FRAME; mRNA.
DR EMBL; AK074503; BAC11027.1; -; mRNA.
DR EMBL; CH471052; EAW78033.1; -; Genomic_DNA.
DR EMBL; BC039689; AAH39689.1; -; mRNA.
DR EMBL; BC064989; AAH64989.1; -; mRNA.
DR CCDS; CCDS33923.1; -.
DR RefSeq; NP_710157.2; NM_153690.4.
DR AlphaFoldDB; Q8N2R8; -.
DR SMR; Q8N2R8; -.
DR BioGRID; 126288; 42.
DR IntAct; Q8N2R8; 9.
DR STRING; 9606.ENSP00000371397; -.
DR iPTMnet; Q8N2R8; -.
DR PhosphoSitePlus; Q8N2R8; -.
DR BioMuta; FAM43A; -.
DR DMDM; 51316022; -.
DR EPD; Q8N2R8; -.
DR MassIVE; Q8N2R8; -.
DR PaxDb; Q8N2R8; -.
DR PeptideAtlas; Q8N2R8; -.
DR PRIDE; Q8N2R8; -.
DR ProteomicsDB; 71730; -.
DR Antibodypedia; 68591; 36 antibodies from 10 providers.
DR DNASU; 131583; -.
DR Ensembl; ENST00000329759.6; ENSP00000371397.1; ENSG00000185112.6.
DR GeneID; 131583; -.
DR KEGG; hsa:131583; -.
DR MANE-Select; ENST00000329759.6; ENSP00000371397.1; NM_153690.5; NP_710157.2.
DR UCSC; uc003fuj.4; human.
DR CTD; 131583; -.
DR DisGeNET; 131583; -.
DR GeneCards; FAM43A; -.
DR HGNC; HGNC:26888; FAM43A.
DR HPA; ENSG00000185112; Tissue enhanced (lymphoid).
DR neXtProt; NX_Q8N2R8; -.
DR OpenTargets; ENSG00000185112; -.
DR PharmGKB; PA134950686; -.
DR VEuPathDB; HostDB:ENSG00000185112; -.
DR eggNOG; KOG4448; Eukaryota.
DR GeneTree; ENSGT00940000161593; -.
DR HOGENOM; CLU_056673_2_0_1; -.
DR InParanoid; Q8N2R8; -.
DR OMA; AMHLECG; -.
DR OrthoDB; 1201276at2759; -.
DR PhylomeDB; Q8N2R8; -.
DR TreeFam; TF314159; -.
DR PathwayCommons; Q8N2R8; -.
DR SignaLink; Q8N2R8; -.
DR BioGRID-ORCS; 131583; 11 hits in 1073 CRISPR screens.
DR ChiTaRS; FAM43A; human.
DR GeneWiki; FAM43A; -.
DR GenomeRNAi; 131583; -.
DR Pharos; Q8N2R8; Tdark.
DR PRO; PR:Q8N2R8; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q8N2R8; protein.
DR Bgee; ENSG00000185112; Expressed in pons and 161 other tissues.
DR Genevisible; Q8N2R8; HS.
DR CDD; cd01214; PTB_FAM43A; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR033930; FAM43A/B_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR Pfam; PF14719; PID_2; 1.
DR SMART; SM00462; PTB; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..423
FT /note="Protein FAM43A"
FT /id="PRO_0000187024"
FT REGION 263..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 321..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 382..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..279
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 280..297
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..411
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 305
FT /note="A -> V (in Ref. 2; BAC11027)"
FT /evidence="ECO:0000305"
FT CONFLICT 351
FT /note="A -> V (in Ref. 1; AAL55769)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 423 AA; 45776 MW; AA70223F96B2729A CRC64;
MLPWKKHKFE LLAEAPPRQA SKPKGYAVSL HYSALSSLAR ACPEGALSRV GSMFRSKRKK
LHITSEDPTY TVLYLGNATT IQARGDGCTD LAVGKIWSKS EAGRQGTKMK LTVSAQGIRM
VHAEERALRR PGHLYLLHRV TYCVADARLP KVFAWVYRHE LKHKAVMLRC HAVLVSKPEK
AQAMALLLYQ TSANALAEFK RLKRRDDARH QQQELVGAHT IPLVPLRKLL LHGPCCYKPP
VERSRSAPKL GSITEDLLGE QLEQELQEEE EEEQPEGCPE EEENRAAEGD PAEEEAEAQR
ALVVAMHFEC GDLLDTLENG RGEALGGGGG SLGPGAGPPP LLLGSASDMK AELSQLISDL
GELSFGNDVR TLQADLRVTR LLSGDSTGSE SSIEGGGPDA TSATAGDSSR QADGASADEP
HSG
