FA43B_HUMAN
ID FA43B_HUMAN Reviewed; 329 AA.
AC Q6ZT52; A5PKT8; A5PL01;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Protein FAM43B;
GN Name=FAM43B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the FAM43 family. {ECO:0000305}.
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DR EMBL; AK126900; BAC86742.1; -; mRNA.
DR EMBL; AL391357; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC142610; AAI42611.1; -; mRNA.
DR EMBL; BC142686; AAI42687.1; -; mRNA.
DR CCDS; CCDS209.1; -.
DR RefSeq; NP_997217.1; NM_207334.2.
DR AlphaFoldDB; Q6ZT52; -.
DR SMR; Q6ZT52; -.
DR BioGRID; 127883; 2.
DR STRING; 9606.ENSP00000331397; -.
DR iPTMnet; Q6ZT52; -.
DR PhosphoSitePlus; Q6ZT52; -.
DR BioMuta; FAM43B; -.
DR DMDM; 51315883; -.
DR MassIVE; Q6ZT52; -.
DR PaxDb; Q6ZT52; -.
DR PeptideAtlas; Q6ZT52; -.
DR PRIDE; Q6ZT52; -.
DR Antibodypedia; 62545; 11 antibodies from 7 providers.
DR DNASU; 163933; -.
DR Ensembl; ENST00000332947.6; ENSP00000331397.4; ENSG00000183114.8.
DR GeneID; 163933; -.
DR KEGG; hsa:163933; -.
DR MANE-Select; ENST00000332947.6; ENSP00000331397.4; NM_207334.3; NP_997217.1.
DR UCSC; uc001bdj.4; human.
DR CTD; 163933; -.
DR DisGeNET; 163933; -.
DR GeneCards; FAM43B; -.
DR HGNC; HGNC:31791; FAM43B.
DR HPA; ENSG00000183114; Group enriched (adrenal gland, brain).
DR neXtProt; NX_Q6ZT52; -.
DR OpenTargets; ENSG00000183114; -.
DR PharmGKB; PA134976508; -.
DR VEuPathDB; HostDB:ENSG00000183114; -.
DR eggNOG; KOG4448; Eukaryota.
DR GeneTree; ENSGT00940000162826; -.
DR HOGENOM; CLU_056673_0_0_1; -.
DR InParanoid; Q6ZT52; -.
DR OMA; KGEGCTQ; -.
DR OrthoDB; 1201276at2759; -.
DR PhylomeDB; Q6ZT52; -.
DR TreeFam; TF314159; -.
DR PathwayCommons; Q6ZT52; -.
DR BioGRID-ORCS; 163933; 15 hits in 1070 CRISPR screens.
DR GenomeRNAi; 163933; -.
DR Pharos; Q6ZT52; Tdark.
DR PRO; PR:Q6ZT52; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q6ZT52; protein.
DR Bgee; ENSG00000183114; Expressed in right adrenal gland cortex and 105 other tissues.
DR Genevisible; Q6ZT52; HS.
DR CDD; cd01214; PTB_FAM43A; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR033930; FAM43A/B_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR Pfam; PF14719; PID_2; 1.
DR SMART; SM00462; PTB; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..329
FT /note="Protein FAM43B"
FT /id="PRO_0000187026"
FT REGION 245..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..279
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 135
FT /note="R -> L (in Ref. 3; AAI42611)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 329 AA; 36776 MW; 561C5323A180A773 CRC64;
MLPWRRNKFV LVEDEAKCKA KSLSPGLAYT SLLSSFLRSC PDLLPDWPLE RLGRVFRSRR
QKVELNKEDP TYTVWYLGNA VTLHAKGDGC TDDAVGKIWA RCGPGGGTKM KLTLGPHGIR
MQPCERSAAG GSGGRRPAHA YLLPRITYCT ADGRHPRVFA WVYRHQARHK AVVLRCHAVL
LARAHKARAL ARLLRQTALA AFSDFKRLQR QSDARHVRQQ HLRAGGAAAS VPRAPLRRLL
NAKCAYRPPP SERSRGAPRL SSIQEEDEEE EEDDAEEQEG GVPQRERPEV LSLARELRTC
SLRGAPAPPP PAQPRRWKAG PRERAGQAR
