FA47B_HUMAN
ID FA47B_HUMAN Reviewed; 645 AA.
AC Q8NA70; Q5JQN5; Q6PIG3;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 2.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Protein FAM47B;
GN Name=FAM47B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8NA70; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-9247344, EBI-3866279;
CC Q8NA70; Q86Z20: CCDC125; NbExp=3; IntAct=EBI-9247344, EBI-11977221;
CC -!- SIMILARITY: Belongs to the FAM47 family. {ECO:0000305}.
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DR EMBL; AK093101; BAC04056.1; -; mRNA.
DR EMBL; AL645585; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC035026; AAH35026.1; -; mRNA.
DR CCDS; CCDS14236.1; -.
DR RefSeq; NP_689844.2; NM_152631.2.
DR AlphaFoldDB; Q8NA70; -.
DR BioGRID; 127993; 4.
DR IntAct; Q8NA70; 3.
DR STRING; 9606.ENSP00000328307; -.
DR iPTMnet; Q8NA70; -.
DR PhosphoSitePlus; Q8NA70; -.
DR BioMuta; FAM47B; -.
DR DMDM; 71151884; -.
DR EPD; Q8NA70; -.
DR MassIVE; Q8NA70; -.
DR PaxDb; Q8NA70; -.
DR PeptideAtlas; Q8NA70; -.
DR PRIDE; Q8NA70; -.
DR ProteomicsDB; 72649; -.
DR Antibodypedia; 24781; 33 antibodies from 12 providers.
DR DNASU; 170062; -.
DR Ensembl; ENST00000329357.6; ENSP00000328307.5; ENSG00000189132.6.
DR GeneID; 170062; -.
DR KEGG; hsa:170062; -.
DR MANE-Select; ENST00000329357.6; ENSP00000328307.5; NM_152631.3; NP_689844.2.
DR UCSC; uc004ddi.3; human.
DR CTD; 170062; -.
DR GeneCards; FAM47B; -.
DR HGNC; HGNC:26659; FAM47B.
DR HPA; ENSG00000189132; Tissue enriched (testis).
DR neXtProt; NX_Q8NA70; -.
DR OpenTargets; ENSG00000189132; -.
DR PharmGKB; PA134969396; -.
DR VEuPathDB; HostDB:ENSG00000189132; -.
DR eggNOG; ENOG502SEIG; Eukaryota.
DR GeneTree; ENSGT00940000165290; -.
DR HOGENOM; CLU_424481_0_0_1; -.
DR InParanoid; Q8NA70; -.
DR OMA; RYGPWYF; -.
DR OrthoDB; 678383at2759; -.
DR PhylomeDB; Q8NA70; -.
DR TreeFam; TF340932; -.
DR PathwayCommons; Q8NA70; -.
DR SignaLink; Q8NA70; -.
DR BioGRID-ORCS; 170062; 10 hits in 685 CRISPR screens.
DR GenomeRNAi; 170062; -.
DR Pharos; Q8NA70; Tdark.
DR PRO; PR:Q8NA70; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q8NA70; protein.
DR Bgee; ENSG00000189132; Expressed in sperm and 14 other tissues.
DR Genevisible; Q8NA70; HS.
DR InterPro; IPR032743; FAM47.
DR Pfam; PF14642; FAM47; 4.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..645
FT /note="Protein FAM47B"
FT /id="PRO_0000187038"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 168..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 202
FT /note="Q -> H (in Ref. 3; AAH35026)"
FT /evidence="ECO:0000305"
FT CONFLICT 220..221
FT /note="VS -> AP (in Ref. 1; BAC04056)"
FT /evidence="ECO:0000305"
FT CONFLICT 299
FT /note="P -> S (in Ref. 1; BAC04056)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 645 AA; 73945 MW; F49BACE4627E3C5D CRC64;
MGDRRPQDRP RSQGMDSKPW YCDKPPSKYF AKRKHRRLRF PPVDTQNWVF VTEGMDDFRY
ACQSPEDTLV CRRDEFLLPK ISLRGPQADR KSRKKKLLKK AALFSELSPV QPARKAFVEE
VEAQLMTKHP LAMYPNLGKD MPPDLLLQVL KQLDPERKLE DAWARCEARE KTTEVPTESG
KYPCGESCPR PPETPVSRLR PQLPKTPVSS RRPEPPKTRV SSLRPEPPKT RVSSLHPEPP
ETRASHLRVD PPETGVSHLC PEPPKTLVSS VHPEPPDTGA SHLCPEPPET RVSHLHPEPP
ETGVSHLRPE PSKTQVSSLC PEPPEAGVSH LCLEPPNTHR VSSFLLQVLK LDSEKKLEDA
RARCEGQEMT TEELTKPGKY HFWESCPRPF ESRMPHLRLV LPITRRMASL CLKPPKTRRV
SSLCPEPTKT GASHLKELFQ EDTPSTMECV SDSLQRRHTS RKLRDFKWAG DLGVNEESIS
SLFDFTPECR TTDQDQKIKK ANECASRLMY GMELDDMDEV EFLRIKYWDR RRRAAPHSYS
AQRGRIRYGP WYFEPKLGKK LRSDEPLIDP KPVLEKPDEP DILDGLYGPI AFKDFILSKG
YRMPGVIEKL FAKKGWTYDS VKTPIQRAVQ VYKYKEDVTD ASKED
