ID   FA50A_XENTR             Reviewed;         350 AA.
AC   Q28BK4; B5DES4;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 2.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Protein FAM50A;
GN   Name=fam50a; ORFNames=TEgg035a20.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=PopA; TISSUE=Tail bud;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probably involved in the regulation of pre-mRNA splicing.
CC       {ECO:0000250|UniProtKB:Q568K9}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q14320}.
CC   -!- SIMILARITY: Belongs to the FAM50 family. {ECO:0000305}.
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DR   EMBL; CR942792; CAJ82230.1; -; mRNA.
DR   EMBL; BC168785; AAI68785.1; -; mRNA.
DR   RefSeq; NP_001039249.1; NM_001045784.1.
DR   AlphaFoldDB; Q28BK4; -.
DR   STRING; 8364.ENSXETP00000007322; -.
DR   PaxDb; Q28BK4; -.
DR   GeneID; 734115; -.
DR   KEGG; xtr:734115; -.
DR   CTD; 9130; -.
DR   Xenbase; XB-GENE-970297; fam50a.
DR   eggNOG; KOG2894; Eukaryota.
DR   InParanoid; Q28BK4; -.
DR   OrthoDB; 1061864at2759; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0006325; P:chromatin organization; IBA:GO_Central.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   InterPro; IPR007005; XAP5.
DR   PANTHER; PTHR12722; PTHR12722; 1.
DR   Pfam; PF04921; XAP5; 1.
PE   2: Evidence at transcript level;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome.
FT   CHAIN           1..350
FT                   /note="Protein FAM50A"
FT                   /id="PRO_0000326511"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          104..186
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        15..29
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        104..123
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        124..156
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        157..186
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        126
FT                   /note="E -> ED (in Ref. 1; CAJ82230)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        143
FT                   /note="Missing (in Ref. 1; CAJ82230)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        149
FT                   /note="Missing (in Ref. 1; CAJ82230)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   350 AA;  41550 MW;  4FB076900FAC50D4 CRC64;
     MAQYKGAASE AGRAMQLMKK REKQREQLEQ MKQKIAEENV VKANINKKFS AHYDAVEAEL
     KSSTVGLVTL NDMKAKQEAL VKEREKQLAK KEQFKDLQLK LEKQRERERK KEQKRKIASL
     SFNLEEDEEC EDEEADDDYD DEEDDDDEDD DDDDAEKEEL PKKKKKLGKN PDVDTSFLPD
     RDREEEENRL REELRQEWER KQEKIKSEEI EITFSYWDGS GHRRTVKMKK GNSIQQFLQK
     ALEILRKDFS ELRSAGVEQL MYIKEDLIIP HHHSFYDFIV TKARGKSGPL FNFDVHEDVR
     LLSDATVEKD ESHAGKVVLR SWYEKNKHIF PASRWEPYDP EKKWDKYTIR