FA50B_MOUSE
ID FA50B_MOUSE Reviewed; 334 AA.
AC Q9WTJ8; Q80X84; Q9D993;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Protein FAM50B;
DE AltName: Full=Protein XAP-5-like;
GN Name=Fam50b; Synonyms=D0H6S2654E, X5l;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC TISSUE=Testis;
RX PubMed=10534398; DOI=10.1006/geno.1999.5931;
RA Sedlack Z., Muenstermann E., Dhorne-Pollet S., Otto C., Bock D.,
RA Schuetz G., Poustka A.;
RT "Human and mouse XAP-5 and XAP-5-like (X5L) genes: identification of an
RT ancient functional retroposon differentially expressed in testis.";
RL Genomics 61:125-132(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- TISSUE SPECIFICITY: Widely expressed. Abundant in testis, where it is
CC expressed in seminiferous tubules, not in the interstitium. At the
CC cellular level, expressed in primary spermatocytes and round
CC spermatids, but not detectable in spermatogonia, elongating spermatids,
CC mature spermatozoa, Sertoli cells or Leydig cells.
CC -!- SIMILARITY: Belongs to the FAM50 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AK007247; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Y18506; CAB46283.1; -; mRNA.
DR EMBL; Y18508; CAB46284.1; -; Genomic_DNA.
DR EMBL; AK007247; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS49232.1; -.
DR RefSeq; NP_620085.2; NM_138746.2.
DR RefSeq; XP_006516589.1; XM_006516526.1.
DR AlphaFoldDB; Q9WTJ8; -.
DR BioGRID; 223874; 4.
DR STRING; 10090.ENSMUSP00000046980; -.
DR iPTMnet; Q9WTJ8; -.
DR PhosphoSitePlus; Q9WTJ8; -.
DR MaxQB; Q9WTJ8; -.
DR PaxDb; Q9WTJ8; -.
DR PeptideAtlas; Q9WTJ8; -.
DR PRIDE; Q9WTJ8; -.
DR ProteomicsDB; 277028; -.
DR Antibodypedia; 24439; 67 antibodies from 15 providers.
DR Ensembl; ENSMUST00000039605; ENSMUSP00000046980; ENSMUSG00000038246.
DR Ensembl; ENSMUST00000221037; ENSMUSP00000152187; ENSMUSG00000038246.
DR GeneID; 108161; -.
DR KEGG; mmu:108161; -.
DR UCSC; uc007qbl.1; mouse.
DR CTD; 26240; -.
DR MGI; MGI:1351640; Fam50b.
DR VEuPathDB; HostDB:ENSMUSG00000038246; -.
DR eggNOG; KOG2894; Eukaryota.
DR GeneTree; ENSGT00390000004735; -.
DR HOGENOM; CLU_037985_1_1_1; -.
DR InParanoid; Q9WTJ8; -.
DR OMA; RMRKGST; -.
DR OrthoDB; 1061864at2759; -.
DR PhylomeDB; Q9WTJ8; -.
DR TreeFam; TF314738; -.
DR BioGRID-ORCS; 108161; 6 hits in 72 CRISPR screens.
DR PRO; PR:Q9WTJ8; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q9WTJ8; protein.
DR Bgee; ENSMUSG00000038246; Expressed in seminiferous tubule of testis and 11 other tissues.
DR Genevisible; Q9WTJ8; MM.
DR GO; GO:0045171; C:intercellular bridge; ISO:MGI.
DR GO; GO:0030496; C:midbody; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0006325; P:chromatin organization; IBA:GO_Central.
DR InterPro; IPR007005; XAP5.
DR PANTHER; PTHR12722; PTHR12722; 1.
DR Pfam; PF04921; XAP5; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q9Y247"
FT CHAIN 2..334
FT /note="Protein FAM50B"
FT /id="PRO_0000068287"
FT REGION 122..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..175
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y247"
FT CONFLICT 229
FT /note="L -> V (in Ref. 2; AK007247)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 334 AA; 39594 MW; 4A438C52BC4A97C6 CRC64;
MAQYKGTMRE AGRAMHLIKK REKQKEQMEV LKQRIAEETI MKSKVDKKFS AHYDAVEAEL
KSSTVGLVTL NDMKAKQEAL LREREMQLAK REQLEQRRIQ LEMLREKERR RERKRKISNL
SFTLDEEEGD QEDSRQAESA EAHSAGAKKN LGKNPDVDTS FLPDREREEE ENRLREELRQ
EWEAKREKVK GEEVEITFSY WDGSGHRRTV RMSKGSTVQQ FLKRALQGLR RDFRELRAAG
VEQLMYVKED LILPHYHTFY DFIVAKARGK SGPLFSFDVH DDVRLLSDAT MEKDESHAGK
VVLRSWYEKN KHIFPASRWE PYDPEKKWDR YTIR
