ID   FA53A_CHICK             Reviewed;         418 AA.
AC   Q5ZKN5; Q5F360; Q8QHJ7;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 2.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Protein FAM53A {ECO:0000250|UniProtKB:Q6NSI3};
DE   AltName: Full=Dorsal neural-tube nuclear protein {ECO:0000303|PubMed:11984880};
GN   Name=FAM53A {ECO:0000250|UniProtKB:Q6NSI3};
GN   Synonyms=DNTNP {ECO:0000303|PubMed:11984880};
GN   ORFNames=RCJMB04_33c19, RCJMB04_9o15;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND
RP   DEVELOPMENTAL STAGE.
RX   PubMed=11984880; DOI=10.1002/dvdy.10090;
RA   Jun L., Balboni A.L., Laitman J.T., Bergemann A.D.;
RT   "Isolation of DNTNP, which encodes a potential nuclear protein that is
RT   expressed in the developing, dorsal neural tube.";
RL   Dev. Dyn. 224:116-123(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: May play an important role in neural development; the
CC       dorsomedial roof of the third ventricle. {ECO:0000269|PubMed:11984880}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11984880}.
CC       Note=Subnuclear distribution. {ECO:0000269|PubMed:11984880}.
CC   -!- DEVELOPMENTAL STAGE: At stage 18, expressed throughout the dorsal
CC       central nervous system (CNS), both within the brain and the spinal
CC       neural. Strongest expression is observed within the tectum and the
CC       cerebellar primordium. Expressed also in the somites, the heart, the
CC       branchial arches, and the limb buds. {ECO:0000269|PubMed:11984880}.
CC   -!- SIMILARITY: Belongs to the FAM53 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAH65424.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AF396666; AAL76115.1; -; mRNA.
DR   EMBL; AJ720049; CAG31708.1; -; mRNA.
DR   EMBL; AJ851790; CAH65424.1; ALT_FRAME; mRNA.
DR   RefSeq; NP_989719.2; NM_204388.2.
DR   RefSeq; XP_015141355.1; XM_015285869.1.
DR   AlphaFoldDB; Q5ZKN5; -.
DR   STRING; 9031.ENSGALP00000036368; -.
DR   PaxDb; Q5ZKN5; -.
DR   Ensembl; ENSGALT00000025340; ENSGALP00000025294; ENSGALG00000015713.
DR   Ensembl; ENSGALT00000087265; ENSGALP00000064240; ENSGALG00000015713.
DR   GeneID; 378905; -.
DR   KEGG; gga:378905; -.
DR   CTD; 152877; -.
DR   VEuPathDB; HostDB:geneid_378905; -.
DR   eggNOG; ENOG502RUYA; Eukaryota.
DR   GeneTree; ENSGT00530000063371; -.
DR   HOGENOM; CLU_054215_0_0_1; -.
DR   InParanoid; Q5ZKN5; -.
DR   OMA; PTGPCPL; -.
DR   OrthoDB; 1614405at2759; -.
DR   PhylomeDB; Q5ZKN5; -.
DR   TreeFam; TF332095; -.
DR   PRO; PR:Q5ZKN5; -.
DR   Proteomes; UP000000539; Chromosome 4.
DR   Bgee; ENSGALG00000015713; Expressed in skeletal muscle tissue and 13 other tissues.
DR   ExpressionAtlas; Q5ZKN5; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0006606; P:protein import into nucleus; IDA:MGI.
DR   InterPro; IPR029356; FAM53.
DR   PANTHER; PTHR28567; PTHR28567; 1.
DR   Pfam; PF15242; FAM53; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..418
FT                   /note="Protein FAM53A"
FT                   /id="PRO_0000261629"
FT   REGION          198..236
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          248..269
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           285..293
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        198..229
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        248..268
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        45
FT                   /note="Missing (in Ref. 2; CAH65424)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        216
FT                   /note="E -> D (in Ref. 1; AAL76115)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        400
FT                   /note="E -> D (in Ref. 2; CAG31708)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   418 AA;  46247 MW;  AAE89140CE729CC0 CRC64;
     MVTLITEKLQ NQSLDDLTCK TYNINLYSSE KLNKSGSLFS FEINEDSPWK ALNGGCPIQT
     DARNSAYPFP VCPFSTGPAS NGALQWQQEP SSTSMVSGWI SELNLNENSG QPLAPPTKRH
     CRSLSEPDEL ARCRSPWKPG NSKVWTPVSK RRCNSGGSAT LQRCNSHGSA TLQRSTSISL
     PQNILSLNNV FTVTSFNTSP VPRPSSASSG FVDSSEGSTS SSTRWNSGGP CDFNPRRRLS
     LSQEHITETG NLLPSANSTP TSTPELSRRQ GLLRCRSQPC VLNEKKSRLK RRREEDVRWN
     RPSLDFFKMT RTLKNSKSLC SLDYEDDDDD TQMKTIVSSP CDSNDLMNII TPGSSPMKEQ
     LDEVRHHGSC QGSFKTRDYK KAAAVCESDE DTSDCESTEE GIFPLDCGDL DLEQIENN