FA53A_MOUSE
ID FA53A_MOUSE Reviewed; 402 AA.
AC E9PV82; Q8R2K2; Q8R5K1; Q91VG1;
DT 05-JUL-2017, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Protein FAM53A {ECO:0000305};
DE AltName: Full=Dorsal neural-tube nuclear protein {ECO:0000303|PubMed:11984880};
GN Name=Fam53a {ECO:0000312|MGI:MGI:1919225};
GN Synonyms=Dntnp {ECO:0000303|PubMed:11984880};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11984880; DOI=10.1002/dvdy.10090;
RA Jun L., Balboni A.L., Laitman J.T., Bergemann A.D.;
RT "Isolation of DNTNP, which encodes a potential nuclear protein that is
RT expressed in the developing, dorsal neural tube.";
RL Dev. Dyn. 224:116-123(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-306 AND SER-309, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May play an important role in neural development; the
CC dorsomedial roof of the third ventricle.
CC {ECO:0000250|UniProtKB:Q5ZKN5}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5ZKN5}.
CC Note=Subnuclear distribution. {ECO:0000250|UniProtKB:Q5ZKN5}.
CC -!- SIMILARITY: Belongs to the FAM53 family. {ECO:0000305}.
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DR EMBL; AF396665; AAL76114.1; -; mRNA.
DR EMBL; AC132233; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC016596; AAH16596.1; -; mRNA.
DR EMBL; BC028656; AAH28656.1; -; mRNA.
DR CCDS; CCDS19203.1; -.
DR RefSeq; NP_848477.2; NM_178390.3.
DR RefSeq; XP_011239077.1; XM_011240775.2.
DR RefSeq; XP_011239078.1; XM_011240776.2.
DR RefSeq; XP_017176611.1; XM_017321122.1.
DR AlphaFoldDB; E9PV82; -.
DR STRING; 10090.ENSMUSP00000070770; -.
DR iPTMnet; E9PV82; -.
DR PhosphoSitePlus; E9PV82; -.
DR jPOST; E9PV82; -.
DR MaxQB; E9PV82; -.
DR PaxDb; E9PV82; -.
DR PRIDE; E9PV82; -.
DR ProteomicsDB; 271843; -.
DR Antibodypedia; 50275; 51 antibodies from 11 providers.
DR DNASU; 74504; -.
DR Ensembl; ENSMUST00000045329; ENSMUSP00000045539; ENSMUSG00000037339.
DR Ensembl; ENSMUST00000065119; ENSMUSP00000070770; ENSMUSG00000037339.
DR GeneID; 74504; -.
DR KEGG; mmu:74504; -.
DR UCSC; uc008xat.2; mouse.
DR CTD; 152877; -.
DR MGI; MGI:1919225; Fam53a.
DR VEuPathDB; HostDB:ENSMUSG00000037339; -.
DR eggNOG; ENOG502RUYA; Eukaryota.
DR GeneTree; ENSGT00530000063371; -.
DR HOGENOM; CLU_054215_0_0_1; -.
DR InParanoid; E9PV82; -.
DR OMA; PTGPCPL; -.
DR OrthoDB; 1614405at2759; -.
DR PhylomeDB; E9PV82; -.
DR TreeFam; TF332095; -.
DR BioGRID-ORCS; 74504; 4 hits in 74 CRISPR screens.
DR ChiTaRS; Fam53a; mouse.
DR PRO; PR:E9PV82; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; E9PV82; protein.
DR Bgee; ENSMUSG00000037339; Expressed in hindlimb stylopod muscle and 257 other tissues.
DR ExpressionAtlas; E9PV82; baseline and differential.
DR Genevisible; Q8R2K2; MM.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0006606; P:protein import into nucleus; ISO:MGI.
DR InterPro; IPR029356; FAM53.
DR PANTHER; PTHR28567; PTHR28567; 1.
DR Pfam; PF15242; FAM53; 1.
PE 1: Evidence at protein level;
KW Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..402
FT /note="Protein FAM53A"
FT /id="PRO_0000440956"
FT REGION 170..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 323..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 273..281
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 199..215
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..339
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 384..402
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 119
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6NSI3"
FT MOD_RES 306
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 309
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 51
FT /note="K -> R (in Ref. 1; AAL76114)"
FT /evidence="ECO:0000305"
FT CONFLICT 241
FT /note="L -> R (in Ref. 1; AAL76114)"
FT /evidence="ECO:0000305"
FT CONFLICT 300
FT /note="T -> A (in Ref. 3; AAH28656)"
FT /evidence="ECO:0000305"
FT CONFLICT 356
FT /note="I -> V (in Ref. 3; AAH16596/AAH28656)"
FT /evidence="ECO:0000305"
FT CONFLICT 365
FT /note="N -> S (in Ref. 3; AAH16596/AAH28656)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 402 AA; 43084 MW; 5C4483F5CC0283B1 CRC64;
MVTLITEKLQ NQSLDDLTRR ACEAGPYSAE KLNKSGHLFP LEISVDKSPW KALRGGWPTG
SQAASGPFSV GPHGVSHTEG LKWQLESPGP MDVGHFLDLH DSTGPPAAPP TKRHCRSLSE
PEELARCRSP WRPGSSKVWT PISKRRCNSG GSATLQCCSG VGNPTLQGTL VPGLPRRPVS
PAGPTSPLTP RPASASSGFV DGSEGSTSSG PPWLSTGPCP FSSRRRLSLS QEHLVDTGAC
LPSASSTPTS TPELGRHHGL LRCRSQPCVL DGRRVRRKRR REEDARWTRP SLDFLKMTRT
LKNSKSLCSL DYEDDEDDTQ EKTLVSSPCN SQGLVGIITP SSSPRIPRPG PDSPSIWASG
EPEANPGEGG SSGDPSDWDS AGEEGIFPLD HGDLDLEQIE NN
