FA53B_MOUSE
ID FA53B_MOUSE Reviewed; 422 AA.
AC Q8BGR5; Q3UGW1; Q8BI13;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Protein FAM53B {ECO:0000305};
GN Name=Fam53b {ECO:0000312|MGI:MGI:1925188};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Brain, Spinal ganglion, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-213; SER-269; SER-335 AND
RP SER-344, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Kidney, Lung, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Acts as a regulator of Wnt signaling pathway by regulating
CC beta-catenin (CTNNB1) nuclear localization.
CC {ECO:0000250|UniProtKB:Q14153}.
CC -!- SUBUNIT: Interacts with CTNNB1. {ECO:0000250|UniProtKB:Q14153}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q14153}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BGR5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BGR5-2; Sequence=VSP_009934;
CC -!- SIMILARITY: Belongs to the FAM53 family. {ECO:0000305}.
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DR EMBL; AK031576; BAC27459.1; -; mRNA.
DR EMBL; AK051299; BAC34597.1; -; mRNA.
DR EMBL; AK147350; BAE27860.1; -; mRNA.
DR EMBL; AK147725; BAE28096.1; -; mRNA.
DR EMBL; BC035523; AAH35523.1; -; mRNA.
DR CCDS; CCDS21926.1; -. [Q8BGR5-1]
DR CCDS; CCDS85437.1; -. [Q8BGR5-2]
DR RefSeq; NP_001334559.1; NM_001347630.1. [Q8BGR5-2]
DR RefSeq; NP_780477.2; NM_175268.4. [Q8BGR5-1]
DR RefSeq; NP_997638.1; NM_212473.1. [Q8BGR5-1]
DR AlphaFoldDB; Q8BGR5; -.
DR STRING; 10090.ENSMUSP00000095608; -.
DR iPTMnet; Q8BGR5; -.
DR PhosphoSitePlus; Q8BGR5; -.
DR EPD; Q8BGR5; -.
DR jPOST; Q8BGR5; -.
DR PaxDb; Q8BGR5; -.
DR PRIDE; Q8BGR5; -.
DR ProteomicsDB; 266823; -. [Q8BGR5-1]
DR ProteomicsDB; 266824; -. [Q8BGR5-2]
DR Antibodypedia; 48489; 45 antibodies from 11 providers.
DR Ensembl; ENSMUST00000065371; ENSMUSP00000070763; ENSMUSG00000030956. [Q8BGR5-1]
DR Ensembl; ENSMUST00000097999; ENSMUSP00000095608; ENSMUSG00000030956. [Q8BGR5-1]
DR Ensembl; ENSMUST00000106168; ENSMUSP00000101774; ENSMUSG00000030956. [Q8BGR5-2]
DR Ensembl; ENSMUST00000106169; ENSMUSP00000101775; ENSMUSG00000030956. [Q8BGR5-1]
DR GeneID; 77938; -.
DR KEGG; mmu:77938; -.
DR UCSC; uc009kcf.1; mouse. [Q8BGR5-1]
DR CTD; 9679; -.
DR MGI; MGI:1925188; Fam53b.
DR VEuPathDB; HostDB:ENSMUSG00000030956; -.
DR eggNOG; ENOG502QQM7; Eukaryota.
DR GeneTree; ENSGT00530000063371; -.
DR HOGENOM; CLU_054215_2_0_1; -.
DR InParanoid; Q8BGR5; -.
DR OMA; DFACASD; -.
DR OrthoDB; 1614405at2759; -.
DR PhylomeDB; Q8BGR5; -.
DR TreeFam; TF332095; -.
DR BioGRID-ORCS; 77938; 4 hits in 72 CRISPR screens.
DR ChiTaRS; Fam53b; mouse.
DR PRO; PR:Q8BGR5; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8BGR5; protein.
DR Bgee; ENSMUSG00000030956; Expressed in rostral migratory stream and 188 other tissues.
DR ExpressionAtlas; Q8BGR5; baseline and differential.
DR Genevisible; Q8BGR5; MM.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; ISS:UniProtKB.
DR GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR GO; GO:0060828; P:regulation of canonical Wnt signaling pathway; ISS:UniProtKB.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR029356; FAM53.
DR PANTHER; PTHR28567; PTHR28567; 1.
DR Pfam; PF15242; FAM53; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Nucleus; Phosphoprotein; Reference proteome;
KW Wnt signaling pathway.
FT CHAIN 1..422
FT /note="Protein FAM53B"
FT /id="PRO_0000189545"
FT REGION 193..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 243..269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 282..285
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000250|UniProtKB:F1QN48"
FT COMPBIAS 243..257
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 119
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q14153"
FT MOD_RES 168
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q14153"
FT MOD_RES 170
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q14153"
FT MOD_RES 180
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q14153"
FT MOD_RES 213
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 269
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 335
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 344
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 1..30
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_009934"
FT CONFLICT 80
FT /note="W -> R (in Ref. 1; BAC27459)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 422 AA; 45939 MW; 79A50F0FC922DDEA CRC64;
MVMILRRSLI NQGADSGAHR TFIPELHTPK MSQGPTLLSC GIMENDRWRD LDRKCPLQID
QPSASIWECL PEKCQDGSLW HQEAVTACAV TSLIKDLNIN DHNGNPSAPP SKRQCRSLSF
SDEMSSCRTS WRPLGSKVWT PVEKRRCYSG GSVQRYSNGV SPMQRSSSFS LPARANGLSS
PCHQSSLHHR FGGQPCQGAP GSAPCGQAGD SWSPDPHPVG GGRLDLQRSL SCSHEQFSFP
EYCPPSANST PASTPELARR SSGLARSRSQ PCVLNDKKIG VKRRRPDEVQ EQRPSLDLAK
MAQNCQTFSS LSCLNMGVDD HSSQSPFALV SSTRSWTALL SASSPGGRTP AGTPVPEPVP
HSFDDQFTCQ EDLSCDESDG CSLDEDCCRK GDPATSWRDR GACTNSLCSL DGELDIEQIE
NN
