ID   FA53B_ORYLA             Reviewed;         407 AA.
AC   H2M146;
DT   05-JUL-2017, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2017, sequence version 2.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Protein FAM53B {ECO:0000250|UniProtKB:Q14153};
DE   AltName: Full=Protein simplet {ECO:0000303|PubMed:16611694};
GN   Name=fam53b {ECO:0000250|UniProtKB:Q14153};
GN   Synonyms=smp {ECO:0000303|PubMed:16611694};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=8090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR;
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA   Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA   Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA   Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA   Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA   Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome evolution.";
RL   Nature 447:714-719(2007).
RN   [2]
RP   DISRUPTION PHENOTYPE, AND TISSUE SPECIFICITY.
RX   PubMed=16611694; DOI=10.1242/dev.02350;
RA   Thermes V., Candal E., Alunni A., Serin G., Bourrat F., Joly J.S.;
RT   "Medaka simplet (FAM53B) belongs to a family of novel vertebrate genes
RT   controlling cell proliferation.";
RL   Development 133:1881-1890(2006).
CC   -!- FUNCTION: Acts as a regulator of Wnt signaling pathway by regulating
CC       beta-catenin (ctnnb1) nuclear localization.
CC       {ECO:0000250|UniProtKB:F1QN48}.
CC   -!- SUBUNIT: Interacts with ctnnb1. {ECO:0000250|UniProtKB:Q14153}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:F1QN48}.
CC   -!- TISSUE SPECIFICITY: Predominantly expressed in proliferating cells
CC       throughout embryonic development. {ECO:0000269|PubMed:16611694}.
CC   -!- DISRUPTION PHENOTYPE: Delayed epiboly and reduced embryonic size.
CC       {ECO:0000269|PubMed:16611694}.
CC   -!- SIMILARITY: Belongs to the FAM53 family. {ECO:0000305}.
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DR   EMBL; BAAF04015981; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04015982; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04015983; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BAAF04015984; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H2M146; -.
DR   STRING; 8090.ENSORLP00000012127; -.
DR   eggNOG; ENOG502QQM7; Eukaryota.
DR   HOGENOM; CLU_054215_2_1_1; -.
DR   TreeFam; TF332095; -.
DR   Proteomes; UP000001038; Unplaced.
DR   Proteomes; UP000265180; Chromosome 9.
DR   Proteomes; UP000265200; Chromosome 9.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; ISS:UniProtKB.
DR   GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR   GO; GO:0060828; P:regulation of canonical Wnt signaling pathway; ISS:UniProtKB.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR029356; FAM53.
DR   PANTHER; PTHR28567; PTHR28567; 1.
DR   Pfam; PF15242; FAM53; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Wnt signaling pathway.
FT   CHAIN           1..407
FT                   /note="Protein FAM53B"
FT                   /id="PRO_0000440958"
FT   REGION          204..286
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          306..380
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           272..275
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250|UniProtKB:F1QN48"
FT   COMPBIAS        204..223
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        261..286
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        328..342
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        344..358
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   407 AA;  44546 MW;  A1397B34B830BEE8 CRC64;
     MVIILKKTLE KKGADDVIAS RANLGPFQAQ TMSQGAALFS CGLMETSRWH DSCSIRQRPV
     GTSLESLWDV LPEVHSGSAQ WDWDVGSASS TLTSLLQDLS LTESSSHSTA PPSKKQCRSL
     SCSDELGGCR STWRPQGSRV WTTVEKRRCH SGGSVQRSSG GNLQLGFPAM QRSFSFSLPA
     RSNAVEPPSF TQRLPYAFTS LTHSSSMPLA SDPPAQPLSL SNEQICFPEP HGPSPSSSPD
     STPELERRSG QGGLARSRSQ PCELNEKKIG VKRRRPDDTH KQRPSLDLAK MTQKLHSFHS
     LSCPGITGEE TCESEATPPP RSVQQRDAVD SPAHEHNLKD FQPQEGDFNG NKSSDPITEE
     VDWNCDDGTP ETSNGKDTEP LWVGLCSMKR DVYQLGGELD IEQIERN