FA53C_HUMAN
ID FA53C_HUMAN Reviewed; 392 AA.
AC Q9NYF3; B2RDJ5; D3DQB9;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Protein FAM53C {ECO:0000305};
GN Name=FAM53C {ECO:0000312|HGNC:HGNC:1336};
GN Synonyms=C5orf6 {ECO:0000312|HGNC:HGNC:1336};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11087669; DOI=10.1006/geno.2000.6345;
RA Lai F., Godley L.A., Fernald A.A., Orelli B.J., Pamintuan L., Zhao N.,
RA Le Beau M.M.;
RT "cDNA cloning and genomic structure of three genes localized to human
RT chromosome band 5q31 encoding potential nuclear proteins.";
RL Genomics 70:123-130(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18220336; DOI=10.1021/pr0705441;
RA Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III;
RT "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient
RT phosphoproteomic analysis.";
RL J. Proteome Res. 7:1346-1351(2008).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-122; SER-232; SER-234 AND
RP SER-255, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-234, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-232 AND SER-234, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [9]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22223895; DOI=10.1074/mcp.m111.015131;
RA Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T.,
RA Giglione C.;
RT "Comparative large-scale characterisation of plant vs. mammal proteins
RT reveals similar and idiosyncratic N-alpha acetylation features.";
RL Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-122; SER-162; SER-232;
RP SER-234; SER-255; SER-273 AND SER-299, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [11]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- INTERACTION:
CC Q9NYF3; V9HW98: HEL2; NbExp=3; IntAct=EBI-1644252, EBI-10190883;
CC Q9NYF3; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-1644252, EBI-16439278;
CC Q9NYF3; O43639: NCK2; NbExp=8; IntAct=EBI-1644252, EBI-713635;
CC Q9NYF3; P31947: SFN; NbExp=3; IntAct=EBI-1644252, EBI-476295;
CC Q9NYF3; O60504: SORBS3; NbExp=3; IntAct=EBI-1644252, EBI-741237;
CC Q9NYF3; P61981: YWHAG; NbExp=6; IntAct=EBI-1644252, EBI-359832;
CC -!- SIMILARITY: Belongs to the FAM53 family. {ECO:0000305}.
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DR EMBL; AF251040; AAF63766.1; -; mRNA.
DR EMBL; AK315567; BAG37942.1; -; mRNA.
DR EMBL; CH471062; EAW62143.1; -; Genomic_DNA.
DR EMBL; CH471062; EAW62144.1; -; Genomic_DNA.
DR EMBL; BC000259; AAH00259.1; -; mRNA.
DR EMBL; BC052993; AAH52993.1; -; mRNA.
DR CCDS; CCDS4204.1; -.
DR RefSeq; NP_001129119.1; NM_001135647.1.
DR RefSeq; NP_057689.1; NM_016605.2.
DR AlphaFoldDB; Q9NYF3; -.
DR BioGRID; 119458; 68.
DR IntAct; Q9NYF3; 22.
DR MINT; Q9NYF3; -.
DR STRING; 9606.ENSP00000239906; -.
DR iPTMnet; Q9NYF3; -.
DR PhosphoSitePlus; Q9NYF3; -.
DR BioMuta; FAM53C; -.
DR DMDM; 66774134; -.
DR EPD; Q9NYF3; -.
DR jPOST; Q9NYF3; -.
DR MassIVE; Q9NYF3; -.
DR MaxQB; Q9NYF3; -.
DR PaxDb; Q9NYF3; -.
DR PeptideAtlas; Q9NYF3; -.
DR PRIDE; Q9NYF3; -.
DR ProteomicsDB; 83218; -.
DR Antibodypedia; 45322; 51 antibodies from 14 providers.
DR DNASU; 51307; -.
DR Ensembl; ENST00000239906.10; ENSP00000239906.5; ENSG00000120709.11.
DR Ensembl; ENST00000434981.6; ENSP00000403705.2; ENSG00000120709.11.
DR GeneID; 51307; -.
DR KEGG; hsa:51307; -.
DR MANE-Select; ENST00000239906.10; ENSP00000239906.5; NM_016605.3; NP_057689.1.
DR UCSC; uc003lcv.4; human.
DR CTD; 51307; -.
DR DisGeNET; 51307; -.
DR GeneCards; FAM53C; -.
DR HGNC; HGNC:1336; FAM53C.
DR HPA; ENSG00000120709; Low tissue specificity.
DR MIM; 609372; gene.
DR neXtProt; NX_Q9NYF3; -.
DR OpenTargets; ENSG00000120709; -.
DR PharmGKB; PA25917; -.
DR VEuPathDB; HostDB:ENSG00000120709; -.
DR eggNOG; ENOG502RW5C; Eukaryota.
DR GeneTree; ENSGT00530000063371; -.
DR HOGENOM; CLU_054215_1_0_1; -.
DR InParanoid; Q9NYF3; -.
DR OMA; WRGLSHC; -.
DR OrthoDB; 1324691at2759; -.
DR PhylomeDB; Q9NYF3; -.
DR TreeFam; TF332095; -.
DR PathwayCommons; Q9NYF3; -.
DR SignaLink; Q9NYF3; -.
DR BioGRID-ORCS; 51307; 7 hits in 1085 CRISPR screens.
DR ChiTaRS; FAM53C; human.
DR GenomeRNAi; 51307; -.
DR Pharos; Q9NYF3; Tdark.
DR PRO; PR:Q9NYF3; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q9NYF3; protein.
DR Bgee; ENSG00000120709; Expressed in left testis and 202 other tissues.
DR ExpressionAtlas; Q9NYF3; baseline and differential.
DR Genevisible; Q9NYF3; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR InterPro; IPR029356; FAM53.
DR PANTHER; PTHR28567; PTHR28567; 1.
DR Pfam; PF15242; FAM53; 1.
PE 1: Evidence at protein level;
KW Acetylation; Phosphoprotein; Reference proteome.
FT CHAIN 1..392
FT /note="Protein FAM53C"
FT /id="PRO_0000189546"
FT REGION 78..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 141..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 204..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 341..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..114
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..294
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0007744|PubMed:22223895"
FT MOD_RES 122
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 162
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 232
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163"
FT MOD_RES 234
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 255
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 273
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 299
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VARIANT 21
FT /note="R -> C (in dbSNP:rs35360938)"
FT /id="VAR_053089"
SQ SEQUENCE 392 AA; 43091 MW; 28ED288D94D81073 CRC64;
MITLITEQLQ KQTLDELKCT RFSISLPLPD HADISNCGNS FQLVSEGASW RGLPHCSCAE
FQDSLNFSYH PSGLSLHLRP PSRGNSPKEQ PFSQVLRPEP PDPEKLPVPP APPSKRHCRS
LSVPVDLSRW QPVWRPAPSK LWTPIKHRGS GGGGGPQVPH QSPPKRVSSL RFLQAPSASS
QCAPAHRPYS PPFFSLALAQ DSSRPCAASP QSGSWESDAE SLSPCPPQRR FSLSPSLGPQ
ASRFLPSARS SPASSPELPW RPRGLRNLPR SRSQPCDLDA RKTGVKRRHE EDPRRLRPSL
DFDKMNQKPY SGGLCLQETA REGSSISPPW FMACSPPPLS ASCSPTGGSS QVLSESEEEE
EGAVRWGRQA LSKRTLCQRD FGDLDLNLIE EN
