FA53C_MOUSE
ID FA53C_MOUSE Reviewed; 393 AA.
AC Q8BXQ8; Q3U4J2;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Protein FAM53C {ECO:0000305};
GN Name=Fam53c {ECO:0000312|MGI:MGI:1913556};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Retina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-232; SER-234 AND SER-255, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Heart, Kidney, Lung, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the FAM53 family. {ECO:0000305}.
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DR EMBL; BC057111; AAH57111.1; -; mRNA.
DR EMBL; AK044469; BAC31938.1; -; mRNA.
DR EMBL; AK154214; BAE32439.1; -; mRNA.
DR CCDS; CCDS29134.1; -.
DR RefSeq; NP_780313.1; NM_175104.4.
DR RefSeq; XP_006526214.1; XM_006526151.3.
DR RefSeq; XP_006526215.1; XM_006526152.2.
DR AlphaFoldDB; Q8BXQ8; -.
DR STRING; 10090.ENSMUSP00000037034; -.
DR iPTMnet; Q8BXQ8; -.
DR PhosphoSitePlus; Q8BXQ8; -.
DR EPD; Q8BXQ8; -.
DR jPOST; Q8BXQ8; -.
DR MaxQB; Q8BXQ8; -.
DR PaxDb; Q8BXQ8; -.
DR PeptideAtlas; Q8BXQ8; -.
DR PRIDE; Q8BXQ8; -.
DR ProteomicsDB; 271844; -.
DR Antibodypedia; 45322; 51 antibodies from 14 providers.
DR DNASU; 66306; -.
DR Ensembl; ENSMUST00000049281; ENSMUSP00000037034; ENSMUSG00000034300.
DR Ensembl; ENSMUST00000097622; ENSMUSP00000095226; ENSMUSG00000034300.
DR GeneID; 66306; -.
DR KEGG; mmu:66306; -.
DR UCSC; uc008eli.1; mouse.
DR CTD; 51307; -.
DR MGI; MGI:1913556; Fam53c.
DR VEuPathDB; HostDB:ENSMUSG00000034300; -.
DR eggNOG; ENOG502RW5C; Eukaryota.
DR GeneTree; ENSGT00530000063371; -.
DR HOGENOM; CLU_054215_1_0_1; -.
DR InParanoid; Q8BXQ8; -.
DR OMA; WRGLSHC; -.
DR OrthoDB; 1324691at2759; -.
DR PhylomeDB; Q8BXQ8; -.
DR TreeFam; TF332095; -.
DR BioGRID-ORCS; 66306; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q8BXQ8; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q8BXQ8; protein.
DR Bgee; ENSMUSG00000034300; Expressed in animal zygote and 244 other tissues.
DR ExpressionAtlas; Q8BXQ8; baseline and differential.
DR Genevisible; Q8BXQ8; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR InterPro; IPR029356; FAM53.
DR PANTHER; PTHR28567; PTHR28567; 1.
DR Pfam; PF15242; FAM53; 1.
PE 1: Evidence at protein level;
KW Acetylation; Phosphoprotein; Reference proteome.
FT CHAIN 1..393
FT /note="Protein FAM53C"
FT /id="PRO_0000189547"
FT REGION 77..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 141..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 204..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 343..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..114
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q9NYF3"
FT MOD_RES 122
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NYF3"
FT MOD_RES 162
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NYF3"
FT MOD_RES 232
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 234
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 255
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 273
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NYF3"
FT MOD_RES 299
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NYF3"
SQ SEQUENCE 393 AA; 43261 MW; 059D5BF355BCDD7F CRC64;
MITLITEQLQ KQTLDELKCT RFSVSLPLPD HADIPNCGDP FQLVSEGASW RGLPHCSCAE
FQDSLNFSYH PSGLSLHLRP PSRGNSPKEP PLSQVLSPEP PDPEKLPVPP APPSKRHCRS
LSVPVDLSRW QPVWRPAPSK LWTPIKHRGN AGGGGPQVPQ QSPPKRVSSL RFLQAPSASS
QCAPAHRPYS PPFFSLALAQ DSAQPCATSP QSGSWESDAE SLSPCPPQRR FSLSPSLGPQ
ASRFLPSARS SPASSPELPW RPRGLRNLPR SRSQPCDLDA RKTGVKRRHE EDCRRLRPSL
DFDKMNQKPY SGGLCLQETA REEGSNVSPP WFMACSPPPL SASCSPVEGS SQVLSESEEE
EEGSVRWERQ ALSKRTLCQQ DFGDLDLNLI EEN
