ID   FA72A_MOUSE             Reviewed;         149 AA.
AC   Q8BFZ8; B2RR49; Q3KQN3;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Protein FAM72A;
GN   Name=Fam72a;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Thymus;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J, and Czech II; TISSUE=Brain, and Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   TISSUE SPECIFICITY.
RX   PubMed=21317926; DOI=10.1038/onc.2011.16;
RA   Wang L.T., Lin C.S., Chai C.Y., Liu K.Y., Chen J.Y., Hsu S.H.;
RT   "Functional interaction of Ugene and EBV infection mediates tumorigenic
RT   effects.";
RL   Oncogene 30:2921-2932(2011).
CC   -!- FUNCTION: May play a role in the regulation of cellular reactive oxygen
CC       species metabolism. May participate in cell growth regulation (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with UNG. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Mitochondrion
CC       {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed at high levels in stomach and also in
CC       kidney and, at low levels, in heart (at protein level). In the stomach,
CC       highly expressed in foveolar cells, parietal cells and chief cells (at
CC       protein level). In kidney, expressed in endothelial cells, mesangial
CC       and epithelial cells (parietal and visceral epithelium) around
CC       glomerulus (at protein level). {ECO:0000269|PubMed:21317926}.
CC   -!- SIMILARITY: Belongs to the FAM72 family. {ECO:0000305}.
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DR   EMBL; AK041641; BAC31018.1; -; mRNA.
DR   EMBL; AK076058; BAC36153.1; -; mRNA.
DR   EMBL; BC090647; AAH90647.1; -; mRNA.
DR   EMBL; BC106123; AAI06124.1; -; mRNA.
DR   EMBL; BC138225; AAI38226.1; -; mRNA.
DR   EMBL; BC145667; AAI45668.1; -; mRNA.
DR   CCDS; CCDS15270.1; -.
DR   RefSeq; NP_780591.1; NM_175382.4.
DR   AlphaFoldDB; Q8BFZ8; -.
DR   STRING; 10090.ENSMUSP00000068111; -.
DR   PhosphoSitePlus; Q8BFZ8; -.
DR   PaxDb; Q8BFZ8; -.
DR   PRIDE; Q8BFZ8; -.
DR   DNASU; 108900; -.
DR   Ensembl; ENSMUST00000068613; ENSMUSP00000068111; ENSMUSG00000055184.
DR   GeneID; 108900; -.
DR   KEGG; mmu:108900; -.
DR   UCSC; uc007cnk.1; mouse.
DR   CTD; 729533; -.
DR   MGI; MGI:1919669; Fam72a.
DR   VEuPathDB; HostDB:ENSMUSG00000055184; -.
DR   eggNOG; ENOG502S1HA; Eukaryota.
DR   GeneTree; ENSGT00390000005106; -.
DR   HOGENOM; CLU_127817_0_0_1; -.
DR   InParanoid; Q8BFZ8; -.
DR   OMA; DICKCKL; -.
DR   OrthoDB; 1574121at2759; -.
DR   PhylomeDB; Q8BFZ8; -.
DR   TreeFam; TF329231; -.
DR   BioGRID-ORCS; 108900; 6 hits in 75 CRISPR screens.
DR   ChiTaRS; Fam72a; mouse.
DR   PRO; PR:Q8BFZ8; -.
DR   Proteomes; UP000000589; Chromosome 1.
DR   RNAct; Q8BFZ8; protein.
DR   Bgee; ENSMUSG00000055184; Expressed in ear vesicle and 130 other tissues.
DR   Genevisible; Q8BFZ8; MM.
DR   GO; GO:0005829; C:cytosol; ISO:MGI.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR   GO; GO:0016020; C:membrane; ISO:MGI.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0031552; P:negative regulation of brain-derived neurotrophic factor-activated receptor activity; ISO:MGI.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; ISO:MGI.
DR   InterPro; IPR026768; FAM72.
DR   PANTHER; PTHR31841; PTHR31841; 1.
DR   Pfam; PF14976; FAM72; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Mitochondrion; Reference proteome.
FT   CHAIN           1..149
FT                   /note="Protein FAM72A"
FT                   /id="PRO_0000340260"
FT   CONFLICT        139
FT                   /note="T -> M (in Ref. 2; AAI06124)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   149 AA;  16626 MW;  DA7F03AAA18C12D1 CRC64;
     MSTNNCTFKD RCVSILCCKF CKQVLSSRGM KAVLLADTDI DLFSTDIPPT NTVDFIGRCY
     FTGICKCKLK DIACLKCGNI VGYHVIVPCS SCLLSCNNGH FWMFHSQAVY GINRLDATGV
     NLLLWGNLPE TEECTDEETL EISAEEYIR