ID   FA72A_RAT               Reviewed;         149 AA.
AC   A1KXW8;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Protein FAM72A;
DE   AltName: Full=Dpr4-related protein;
GN   Name=Fam72a;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Heese K.;
RL   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in the regulation of cellular reactive oxygen
CC       species metabolism. May participate in cell growth regulation (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with UNG. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Mitochondrion
CC       {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed at high levels in stomach and also in
CC       kidney and, at low levels, in heart (at protein level). In the stomach,
CC       highly expressed in foveolar cells, parietal cells and chief cells (at
CC       protein level). In kidney, expressed in endothelial cells, mesangial
CC       and epithelial cells (parietal and visceral epithelium) around
CC       glomerulus (at protein level).
CC   -!- SIMILARITY: Belongs to the FAM72 family. {ECO:0000305}.
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DR   EMBL; AY513720; AAS82862.1; -; mRNA.
DR   RefSeq; NP_001074920.1; NM_001081451.1.
DR   AlphaFoldDB; A1KXW8; -.
DR   STRING; 10116.ENSRNOP00000061509; -.
DR   PhosphoSitePlus; A1KXW8; -.
DR   PaxDb; A1KXW8; -.
DR   GeneID; 681249; -.
DR   KEGG; rno:681249; -.
DR   UCSC; RGD:1598023; rat.
DR   CTD; 729533; -.
DR   RGD; 1598023; Fam72a.
DR   eggNOG; ENOG502S1HA; Eukaryota.
DR   InParanoid; A1KXW8; -.
DR   OrthoDB; 1574121at2759; -.
DR   PhylomeDB; A1KXW8; -.
DR   PRO; PR:A1KXW8; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005829; C:cytosol; IDA:MGI.
DR   GO; GO:0016020; C:membrane; IDA:MGI.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0031552; P:negative regulation of brain-derived neurotrophic factor-activated receptor activity; IDA:MGI.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IDA:MGI.
DR   InterPro; IPR026768; FAM72.
DR   PANTHER; PTHR31841; PTHR31841; 1.
DR   Pfam; PF14976; FAM72; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Mitochondrion; Reference proteome.
FT   CHAIN           1..149
FT                   /note="Protein FAM72A"
FT                   /id="PRO_0000340261"
SQ   SEQUENCE   149 AA;  16756 MW;  14E2F0CC87B41647 CRC64;
     MSTNNCTFKD RCVSILCCKF CKQVLSSRGM KAVLLADTDI DLYSTDIPPT NTVDFIGRCY
     FTGIHKCKLK DIACLKCGNI VGYHVIVPCS SCLLSCNNGH FWMFHSQAVY GINRLDSTGV
     NFLLWGNLPE TEECTDEEML EISAEEYIR