FA76A_HUMAN
ID FA76A_HUMAN Reviewed; 307 AA.
AC Q8TAV0; B4DWT3; O95565; O95566; Q8N7J5;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Protein FAM76A;
GN Name=FAM76A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
RA Rhodes S.;
RL Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5).
RC TISSUE=Esophagus, and Uterus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Blood;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q8TAV0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8TAV0-2; Sequence=VSP_019772;
CC Name=3;
CC IsoId=Q8TAV0-3; Sequence=VSP_019771;
CC Name=4;
CC IsoId=Q8TAV0-4; Sequence=VSP_019771, VSP_019772;
CC Name=5;
CC IsoId=Q8TAV0-5; Sequence=VSP_043250, VSP_019772;
CC -!- SIMILARITY: Belongs to the FAM76 family. {ECO:0000305}.
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DR EMBL; AL035307; CAA22912.1; -; mRNA.
DR EMBL; AL035309; CAA22914.1; -; mRNA.
DR EMBL; AK098318; BAC05285.1; -; mRNA.
DR EMBL; AK301672; BAG63145.1; -; mRNA.
DR EMBL; AL020997; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC025768; AAH25768.1; -; mRNA.
DR CCDS; CCDS309.1; -. [Q8TAV0-1]
DR CCDS; CCDS44092.1; -. [Q8TAV0-3]
DR CCDS; CCDS44093.1; -. [Q8TAV0-4]
DR CCDS; CCDS44094.1; -. [Q8TAV0-2]
DR CCDS; CCDS44095.1; -. [Q8TAV0-5]
DR RefSeq; NP_001137384.1; NM_001143912.1. [Q8TAV0-3]
DR RefSeq; NP_001137385.1; NM_001143913.1. [Q8TAV0-4]
DR RefSeq; NP_001137386.1; NM_001143914.1. [Q8TAV0-2]
DR RefSeq; NP_001137387.1; NM_001143915.1. [Q8TAV0-5]
DR RefSeq; NP_689873.1; NM_152660.2. [Q8TAV0-1]
DR AlphaFoldDB; Q8TAV0; -.
DR SMR; Q8TAV0; -.
DR BioGRID; 128279; 17.
DR IntAct; Q8TAV0; 2.
DR MINT; Q8TAV0; -.
DR iPTMnet; Q8TAV0; -.
DR PhosphoSitePlus; Q8TAV0; -.
DR BioMuta; FAM76A; -.
DR DMDM; 74751363; -.
DR EPD; Q8TAV0; -.
DR jPOST; Q8TAV0; -.
DR MassIVE; Q8TAV0; -.
DR MaxQB; Q8TAV0; -.
DR PeptideAtlas; Q8TAV0; -.
DR PRIDE; Q8TAV0; -.
DR ProteomicsDB; 73922; -. [Q8TAV0-1]
DR ProteomicsDB; 73923; -. [Q8TAV0-2]
DR ProteomicsDB; 73924; -. [Q8TAV0-3]
DR ProteomicsDB; 73925; -. [Q8TAV0-4]
DR ProteomicsDB; 73926; -. [Q8TAV0-5]
DR Antibodypedia; 46783; 118 antibodies from 21 providers.
DR DNASU; 199870; -.
DR Ensembl; ENST00000010299.10; ENSP00000010299.6; ENSG00000009780.16. [Q8TAV0-3]
DR Ensembl; ENST00000234549.11; ENSP00000234549.7; ENSG00000009780.16. [Q8TAV0-4]
DR Ensembl; ENST00000373949.5; ENSP00000363060.1; ENSG00000009780.16. [Q8TAV0-2]
DR Ensembl; ENST00000373954.11; ENSP00000363065.5; ENSG00000009780.16. [Q8TAV0-1]
DR Ensembl; ENST00000419687.6; ENSP00000395150.2; ENSG00000009780.16. [Q8TAV0-5]
DR GeneID; 199870; -.
DR KEGG; hsa:199870; -.
DR MANE-Select; ENST00000373954.11; ENSP00000363065.5; NM_152660.3; NP_689873.1.
DR UCSC; uc001boq.4; human. [Q8TAV0-1]
DR CTD; 199870; -.
DR GeneCards; FAM76A; -.
DR HGNC; HGNC:28530; FAM76A.
DR HPA; ENSG00000009780; Low tissue specificity.
DR neXtProt; NX_Q8TAV0; -.
DR OpenTargets; ENSG00000009780; -.
DR PharmGKB; PA142671837; -.
DR VEuPathDB; HostDB:ENSG00000009780; -.
DR GeneTree; ENSGT00940000160073; -.
DR HOGENOM; CLU_029220_1_0_1; -.
DR InParanoid; Q8TAV0; -.
DR OMA; PCANCKL; -.
DR OrthoDB; 1061935at2759; -.
DR PhylomeDB; Q8TAV0; -.
DR TreeFam; TF313644; -.
DR PathwayCommons; Q8TAV0; -.
DR SignaLink; Q8TAV0; -.
DR BioGRID-ORCS; 199870; 11 hits in 1080 CRISPR screens.
DR ChiTaRS; FAM76A; human.
DR GenomeRNAi; 199870; -.
DR Pharos; Q8TAV0; Tdark.
DR PRO; PR:Q8TAV0; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8TAV0; protein.
DR Bgee; ENSG00000009780; Expressed in calcaneal tendon and 171 other tissues.
DR ExpressionAtlas; Q8TAV0; baseline and differential.
DR Genevisible; Q8TAV0; HS.
DR GO; GO:0016607; C:nuclear speck; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IDA:UniProtKB.
DR InterPro; IPR032017; FAM76.
DR InterPro; IPR029660; FAM76A.
DR PANTHER; PTHR46176; PTHR46176; 1.
DR PANTHER; PTHR46176:SF2; PTHR46176:SF2; 1.
DR Pfam; PF16046; FAM76; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..307
FT /note="Protein FAM76A"
FT /id="PRO_0000245760"
FT REGION 142..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 287..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 217..299
FT /evidence="ECO:0000255"
FT COMPBIAS 142..158
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 49
FT /note="S -> RLECNGTISAHCNLHLPGSSDSPASSSRVAGITGI (in isoform
FT 3 and isoform 4)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_019771"
FT VAR_SEQ 68..118
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_043250"
FT VAR_SEQ 172..200
FT /note="Missing (in isoform 2, isoform 4 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039, ECO:0000303|Ref.1"
FT /id="VSP_019772"
SQ SEQUENCE 307 AA; 35049 MW; C6104F177ADF4AF8 CRC64;
MAALYACTKC HQRFPFEALS QGQQLCKECR IAHPVVKCTY CRTEYQQESK TNTICKKCAQ
NVQLYGTPKP CQYCNIIAAF IGNKCQRCTN SEKKYGPPYS CEQCKQQCAF DRKDDRKKVD
GKLLCWLCTL SYKRVLQKTK EQRKHLSSSS RAGHQEKEQY SRLSGGGHYN SQKTLSTSSI
QNEIPKKKSK FESITTNGDS FSPDLALDSP GTDHFVIIAQ LKEEVATLKK MLHQKDQMIL
EKEKKITELK ADFQYQESQM RAKMNQMEKT HKEVTEQLQA KNRELLKQAA ALSKSKKSEK
SGAITSP
