FA76A_MOUSE
ID FA76A_MOUSE Reviewed; 307 AA.
AC Q922G2; A2ADS2; Q3U3U8; Q3V3N2;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Protein FAM76A;
GN Name=Fam76a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J, and NOD; TISSUE=Hypothalamus, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q922G2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q922G2-2; Sequence=VSP_019773;
CC -!- SIMILARITY: Belongs to the FAM76 family. {ECO:0000305}.
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DR EMBL; AK037828; BAE20524.1; -; mRNA.
DR EMBL; AK038831; BAC30142.1; -; mRNA.
DR EMBL; AK154575; BAE32687.1; -; mRNA.
DR EMBL; AL671190; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC008163; AAH08163.1; -; mRNA.
DR CCDS; CCDS18738.1; -. [Q922G2-1]
DR CCDS; CCDS51320.1; -. [Q922G2-2]
DR RefSeq; NP_001157264.1; NM_001163792.1. [Q922G2-2]
DR RefSeq; NP_663528.1; NM_145553.2. [Q922G2-1]
DR AlphaFoldDB; Q922G2; -.
DR SMR; Q922G2; -.
DR BioGRID; 231028; 1.
DR STRING; 10090.ENSMUSP00000030696; -.
DR iPTMnet; Q922G2; -.
DR PhosphoSitePlus; Q922G2; -.
DR EPD; Q922G2; -.
DR MaxQB; Q922G2; -.
DR PaxDb; Q922G2; -.
DR PeptideAtlas; Q922G2; -.
DR PRIDE; Q922G2; -.
DR ProteomicsDB; 275838; -. [Q922G2-1]
DR ProteomicsDB; 275839; -. [Q922G2-2]
DR Antibodypedia; 46783; 118 antibodies from 21 providers.
DR DNASU; 230789; -.
DR Ensembl; ENSMUST00000030696; ENSMUSP00000030696; ENSMUSG00000028878. [Q922G2-1]
DR Ensembl; ENSMUST00000097856; ENSMUSP00000095468; ENSMUSG00000028878. [Q922G2-2]
DR GeneID; 230789; -.
DR KEGG; mmu:230789; -.
DR UCSC; uc008vbz.2; mouse. [Q922G2-1]
DR UCSC; uc008vca.2; mouse. [Q922G2-2]
DR CTD; 199870; -.
DR MGI; MGI:2385211; Fam76a.
DR VEuPathDB; HostDB:ENSMUSG00000028878; -.
DR eggNOG; KOG3990; Eukaryota.
DR GeneTree; ENSGT00940000160073; -.
DR HOGENOM; CLU_029220_1_0_1; -.
DR InParanoid; Q922G2; -.
DR OMA; PCANCKL; -.
DR OrthoDB; 1061935at2759; -.
DR PhylomeDB; Q922G2; -.
DR TreeFam; TF313644; -.
DR BioGRID-ORCS; 230789; 0 hits in 71 CRISPR screens.
DR ChiTaRS; Fam76a; mouse.
DR PRO; PR:Q922G2; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q922G2; protein.
DR Bgee; ENSMUSG00000028878; Expressed in iris and 247 other tissues.
DR ExpressionAtlas; Q922G2; baseline and differential.
DR Genevisible; Q922G2; MM.
DR GO; GO:0016607; C:nuclear speck; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR InterPro; IPR032017; FAM76.
DR InterPro; IPR029660; FAM76A.
DR PANTHER; PTHR46176; PTHR46176; 1.
DR PANTHER; PTHR46176:SF2; PTHR46176:SF2; 1.
DR Pfam; PF16046; FAM76; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..307
FT /note="Protein FAM76A"
FT /id="PRO_0000245761"
FT REGION 141..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 285..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 217..299
FT /evidence="ECO:0000255"
FT COMPBIAS 141..158
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 172..200
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_019773"
FT CONFLICT 157
FT /note="K -> R (in Ref. 1; BAE32687)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 307 AA; 35095 MW; 67BEAFFD178F0FC4 CRC64;
MAALYACTKC HQRFPFEALS QGQQLCKECR IAHPVVKCTY CRTEYQQESK TNTICKKCAQ
NVQLYGTPKP CQYCNIIAAF IGNKCQRCTN SEKKYGPPYS CEQCKQQCAF DRKDDRKKVD
GKLLCWLCTL SYKRVLQKTK EQRKHLSSSS RGSHQEKEQY SRLSGGSHYN SQKTLSTSSI
QNEIPKKKSK FESITTNGDS FSPDLALDSP GTDHFVIIAQ LKEEVATLKK MLHQKDQMIL
EKEKKITELK ADFQYQESQT RAKMNQMEKT HKEVTEQLQA KNRELLKQAA ALSKSKKSEK
SGTITSP
