FA76B_MOUSE
ID FA76B_MOUSE Reviewed; 339 AA.
AC Q80XP8; Q3UMA6; Q80YR1; Q8CI69;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Protein FAM76B;
GN Name=Fam76b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Mammary gland;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain, Embryo, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-193 AND THR-215, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Kidney, Liver, Lung, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q80XP8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q80XP8-2; Sequence=VSP_019774, VSP_019775, VSP_019776,
CC VSP_019777;
CC -!- DOMAIN: The polyhistidine repeat acts as a targeting signal to nuclear
CC speckles. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the FAM76 family. {ECO:0000305}.
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DR EMBL; AK145026; BAE26192.1; -; mRNA.
DR EMBL; BC036328; AAH36328.1; -; mRNA.
DR EMBL; BC043120; AAH43120.1; -; mRNA.
DR EMBL; BC050870; AAH50870.1; -; mRNA.
DR CCDS; CCDS22819.1; -. [Q80XP8-1]
DR RefSeq; NP_789806.1; NM_176836.3. [Q80XP8-1]
DR RefSeq; XP_006510693.1; XM_006510630.3.
DR AlphaFoldDB; Q80XP8; -.
DR SMR; Q80XP8; -.
DR STRING; 10090.ENSMUSP00000062642; -.
DR iPTMnet; Q80XP8; -.
DR PhosphoSitePlus; Q80XP8; -.
DR EPD; Q80XP8; -.
DR jPOST; Q80XP8; -.
DR MaxQB; Q80XP8; -.
DR PaxDb; Q80XP8; -.
DR PeptideAtlas; Q80XP8; -.
DR PRIDE; Q80XP8; -.
DR ProteomicsDB; 277029; -. [Q80XP8-1]
DR ProteomicsDB; 277030; -. [Q80XP8-2]
DR Antibodypedia; 31661; 109 antibodies from 18 providers.
DR DNASU; 72826; -.
DR Ensembl; ENSMUST00000059579; ENSMUSP00000062642; ENSMUSG00000037808. [Q80XP8-1]
DR GeneID; 72826; -.
DR KEGG; mmu:72826; -.
DR UCSC; uc009oef.1; mouse. [Q80XP8-1]
DR UCSC; uc009oeh.1; mouse. [Q80XP8-2]
DR CTD; 143684; -.
DR MGI; MGI:1920076; Fam76b.
DR VEuPathDB; HostDB:ENSMUSG00000037808; -.
DR eggNOG; KOG3990; Eukaryota.
DR GeneTree; ENSGT00940000159074; -.
DR HOGENOM; CLU_029220_1_0_1; -.
DR InParanoid; Q80XP8; -.
DR OMA; KECRGAF; -.
DR OrthoDB; 1061935at2759; -.
DR PhylomeDB; Q80XP8; -.
DR TreeFam; TF313644; -.
DR BioGRID-ORCS; 72826; 2 hits in 70 CRISPR screens.
DR ChiTaRS; Fam76b; mouse.
DR PRO; PR:Q80XP8; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q80XP8; protein.
DR Bgee; ENSMUSG00000037808; Expressed in paneth cell and 251 other tissues.
DR ExpressionAtlas; Q80XP8; baseline and differential.
DR Genevisible; Q80XP8; MM.
DR GO; GO:0016607; C:nuclear speck; ISS:UniProtKB.
DR InterPro; IPR032017; FAM76.
DR InterPro; IPR029661; FAM76B.
DR PANTHER; PTHR46176; PTHR46176; 1.
DR PANTHER; PTHR46176:SF3; PTHR46176:SF3; 1.
DR Pfam; PF16046; FAM76; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Coiled coil; Nucleus; Phosphoprotein;
KW Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q5HYJ3"
FT CHAIN 2..339
FT /note="Protein FAM76B"
FT /id="PRO_0000245764"
FT REGION 144..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 248..328
FT /evidence="ECO:0000255"
FT COMPBIAS 167..187
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..214
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..243
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q5HYJ3"
FT MOD_RES 22
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5HYJ3"
FT MOD_RES 148
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5HYJ3"
FT MOD_RES 193
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 215
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 1..208
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_019774"
FT VAR_SEQ 209..230
FT /note="AAIQNETPKKKPKLESKPSNGD -> MQFEHLQIFLLLYVIPFYFFLF (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_019775"
FT VAR_SEQ 311..319
FT /note="AKNRELLKQ -> VNGVIYVRC (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_019776"
FT VAR_SEQ 320..339
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_019777"
FT CONFLICT 180
FT /note="H -> HH (in Ref. 1; BAE26192)"
FT /evidence="ECO:0000305"
FT CONFLICT 233
FT /note="Missing (in Ref. 2; AAH50870)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 339 AA; 38556 MW; 9A64D910ECC71178 CRC64;
MAASALYACT KCTQRYPFEE LSQGQQLCKE CRIAHPIVKC TYCRSEFQQE SKTNTICKKC
AQNVKQFGTP KPCQYCNIIA AFIGTKCQRC TNSEKKYGAP QTCEQCKQQC AFDRKEEGRR
KVDGKLLCWL CTLSYKRVLQ KTKEQRKSLG SSHSNSSSSS LTEKDQHHSK HHHHHHHHHH
RHSSGHHKVS SLSPEQEQGL WKQSHKSSAA IQNETPKKKP KLESKPSNGD SSSINQSADS
GGTDNFVLIS QLKEEVMSLK RLLQQRDQTI LEKDKKLTEL KADFQYQESN LRTKMNSMEK
AHKETVEQLQ AKNRELLKQV AALSKGKKFD KSGSVLTSP
