FA78B_HUMAN
ID FA78B_HUMAN Reviewed; 261 AA.
AC Q5VT40; B7Z693;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Protein FAM78B;
GN Name=FAM78B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the FAM78 family. {ECO:0000305}.
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DR EMBL; AK299946; BAH13179.1; -; mRNA.
DR EMBL; AL626787; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL596087; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471067; EAW90771.1; -; Genomic_DNA.
DR EMBL; BC114214; AAI14215.1; -; mRNA.
DR CCDS; CCDS30931.1; -.
DR RefSeq; NP_001017961.1; NM_001017961.4.
DR RefSeq; XP_016855906.1; XM_017000417.1.
DR RefSeq; XP_016855907.1; XM_017000418.1.
DR AlphaFoldDB; Q5VT40; -.
DR BioGRID; 127202; 6.
DR IntAct; Q5VT40; 5.
DR STRING; 9606.ENSP00000339681; -.
DR BioMuta; FAM78B; -.
DR DMDM; 74746881; -.
DR jPOST; Q5VT40; -.
DR MaxQB; Q5VT40; -.
DR PaxDb; Q5VT40; -.
DR PeptideAtlas; Q5VT40; -.
DR PRIDE; Q5VT40; -.
DR ProteomicsDB; 65301; -.
DR Antibodypedia; 34334; 125 antibodies from 17 providers.
DR DNASU; 149297; -.
DR Ensembl; ENST00000338353.3; ENSP00000339681.3; ENSG00000188859.7.
DR Ensembl; ENST00000354422.4; ENSP00000346404.3; ENSG00000188859.7.
DR Ensembl; ENST00000456900.1; ENSP00000389945.1; ENSG00000188859.7.
DR GeneID; 149297; -.
DR KEGG; hsa:149297; -.
DR MANE-Select; ENST00000354422.4; ENSP00000346404.3; NM_001017961.5; NP_001017961.1.
DR UCSC; uc021pef.2; human.
DR CTD; 149297; -.
DR DisGeNET; 149297; -.
DR GeneCards; FAM78B; -.
DR HGNC; HGNC:13495; FAM78B.
DR HPA; ENSG00000188859; Tissue enhanced (brain).
DR neXtProt; NX_Q5VT40; -.
DR OpenTargets; ENSG00000188859; -.
DR PharmGKB; PA142671841; -.
DR VEuPathDB; HostDB:ENSG00000188859; -.
DR eggNOG; ENOG502QPXK; Eukaryota.
DR GeneTree; ENSGT00390000018059; -.
DR HOGENOM; CLU_085745_0_0_1; -.
DR InParanoid; Q5VT40; -.
DR OMA; IQACTHM; -.
DR OrthoDB; 958650at2759; -.
DR PhylomeDB; Q5VT40; -.
DR TreeFam; TF329533; -.
DR PathwayCommons; Q5VT40; -.
DR SignaLink; Q5VT40; -.
DR BioGRID-ORCS; 149297; 9 hits in 1068 CRISPR screens.
DR GenomeRNAi; 149297; -.
DR Pharos; Q5VT40; Tdark.
DR PRO; PR:Q5VT40; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5VT40; protein.
DR Bgee; ENSG00000188859; Expressed in endothelial cell and 118 other tissues.
DR ExpressionAtlas; Q5VT40; baseline and differential.
DR Genevisible; Q5VT40; HS.
DR InterPro; IPR029638; FAM78.
DR InterPro; IPR029639; FAM78B.
DR PANTHER; PTHR31655; PTHR31655; 1.
DR PANTHER; PTHR31655:SF0; PTHR31655:SF0; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..261
FT /note="Protein FAM78B"
FT /id="PRO_0000265114"
SQ SEQUENCE 261 AA; 29835 MW; C22AA46C66136565 CRC64;
MGCIQSITCK ARIRRENIVV YDVCATIDQC PTRIEETSPI VLRYKTPYFK ASARVVMPPI
PRHETWVVGW IQACNQMEFF NTYSDLGMSS WELPDLREGR VKAISDSDGV SYPWYGNTTE
TVTLVGPTNK ISRFSVSMND NFYPSVTWAV PVSDSNVPLL TRIKRDQSFT TWLVAMNTTT
KEKIILQTIK WRMRVDIEVD PLQLLGQRAR LVGRTQQEQP RILSRMEPIP PNALVKPNAN
DAQVLMWRPK RGPPLVVIPP K
