FA81A_HUMAN
ID FA81A_HUMAN Reviewed; 368 AA.
AC Q8TBF8;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 3.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Protein FAM81A;
GN Name=FAM81A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8TBF8; Q9ULW6: NAP1L2; NbExp=3; IntAct=EBI-11993062, EBI-3911716;
CC Q8TBF8; Q15154-3: PCM1; NbExp=5; IntAct=EBI-11993062, EBI-11742977;
CC Q8TBF8; Q9P2K3-2: RCOR3; NbExp=3; IntAct=EBI-11993062, EBI-1504830;
CC Q8TBF8; P61266: STX1B; NbExp=3; IntAct=EBI-11993062, EBI-9071709;
CC Q8TBF8; Q9UBB9: TFIP11; NbExp=3; IntAct=EBI-11993062, EBI-1105213;
CC Q8TBF8; P40222: TXLNA; NbExp=3; IntAct=EBI-11993062, EBI-359793;
CC Q8TBF8; Q8N720: ZNF655; NbExp=3; IntAct=EBI-11993062, EBI-625509;
CC -!- SIMILARITY: Belongs to the FAM81 family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-4 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH22537.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC091748; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC092754; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC022537; AAH22537.1; ALT_INIT; mRNA.
DR CCDS; CCDS45269.1; -.
DR RefSeq; NP_689663.2; NM_152450.2.
DR RefSeq; XP_006720461.1; XM_006720398.3.
DR RefSeq; XP_006720462.1; XM_006720399.2.
DR RefSeq; XP_011519551.1; XM_011521249.2.
DR RefSeq; XP_011519552.1; XM_011521250.2.
DR AlphaFoldDB; Q8TBF8; -.
DR SMR; Q8TBF8; -.
DR BioGRID; 126935; 21.
DR IntAct; Q8TBF8; 7.
DR STRING; 9606.ENSP00000288228; -.
DR iPTMnet; Q8TBF8; -.
DR PhosphoSitePlus; Q8TBF8; -.
DR BioMuta; FAM81A; -.
DR DMDM; 341941102; -.
DR jPOST; Q8TBF8; -.
DR MassIVE; Q8TBF8; -.
DR PaxDb; Q8TBF8; -.
DR PeptideAtlas; Q8TBF8; -.
DR PRIDE; Q8TBF8; -.
DR ProteomicsDB; 74013; -.
DR Antibodypedia; 42746; 73 antibodies from 14 providers.
DR DNASU; 145773; -.
DR Ensembl; ENST00000288228.10; ENSP00000288228.5; ENSG00000157470.12.
DR GeneID; 145773; -.
DR KEGG; hsa:145773; -.
DR MANE-Select; ENST00000288228.10; ENSP00000288228.5; NM_152450.3; NP_689663.2.
DR UCSC; uc002agc.3; human.
DR CTD; 145773; -.
DR DisGeNET; 145773; -.
DR GeneCards; FAM81A; -.
DR HGNC; HGNC:28379; FAM81A.
DR HPA; ENSG00000157470; Tissue enhanced (brain).
DR neXtProt; NX_Q8TBF8; -.
DR OpenTargets; ENSG00000157470; -.
DR PharmGKB; PA142671846; -.
DR VEuPathDB; HostDB:ENSG00000157470; -.
DR eggNOG; ENOG502S0X8; Eukaryota.
DR GeneTree; ENSGT00390000004985; -.
DR HOGENOM; CLU_056304_1_0_1; -.
DR InParanoid; Q8TBF8; -.
DR OMA; KQEVPRW; -.
DR PhylomeDB; Q8TBF8; -.
DR TreeFam; TF335682; -.
DR PathwayCommons; Q8TBF8; -.
DR SignaLink; Q8TBF8; -.
DR BioGRID-ORCS; 145773; 9 hits in 1059 CRISPR screens.
DR ChiTaRS; FAM81A; human.
DR GenomeRNAi; 145773; -.
DR Pharos; Q8TBF8; Tdark.
DR PRO; PR:Q8TBF8; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q8TBF8; protein.
DR Bgee; ENSG00000157470; Expressed in cortical plate and 101 other tissues.
DR ExpressionAtlas; Q8TBF8; baseline and differential.
DR Genevisible; Q8TBF8; HS.
DR InterPro; IPR029619; FAM81.
DR InterPro; IPR029622; FAM81A.
DR PANTHER; PTHR22420; PTHR22420; 1.
DR PANTHER; PTHR22420:SF2; PTHR22420:SF2; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..368
FT /note="Protein FAM81A"
FT /id="PRO_0000265119"
FT COILED 78..110
FT /evidence="ECO:0000255"
FT COILED 161..192
FT /evidence="ECO:0000255"
FT COILED 236..290
FT /evidence="ECO:0000255"
FT CONFLICT 339
FT /note="L -> I (in Ref. 2; AAH22537)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 368 AA; 42392 MW; B4A41A79F5714233 CRC64;
MENMHLRRVR TMPRHSQSLT MAPYSSVSLV EQLEDRILCH EKTTAALVEH AFRIKDDIVN
SLQKMQNKGG GDRLARLFLE EHIRNITAIV KQLNRDIEVL QEQIRARDNI SYGTNSALKT
LEMRQLSGLG DLRGRVARCD ASIARLSAEH KTTYEGLQHL NKEQQAAKLI LETKIKDAEG
QISQLLNRVD LSISEQSTKL KMSHRDSNHQ LQLLDTKFKG TVEELSNQIL SARSWLQQEQ
ERIEKELLQK IDQLSLIVKE NSGASERDME KKLSQMSARL DKIEEGQKKT FDGQRTRQEE
EKMHGRITKL ELQMNQNIKE MKAEVNAGFT AVYESIGSLR QVLEAKMKLD RDQLQKQIQL
MQKPETPM
