FA81A_MOUSE
ID FA81A_MOUSE Reviewed; 364 AA.
AC Q3UXZ6; Q8BQV1; Q8C548; Q8R3B5; Q9D369;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 12-DEC-2006, sequence version 2.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Protein FAM81A;
GN Name=Fam81a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RC TISSUE=Corpora quadrigemina, Hypothalamus, and Olfactory bulb;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the FAM81 family. {ECO:0000305}.
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DR EMBL; AK018282; BAB31146.1; -; mRNA.
DR EMBL; AK044090; BAC31769.1; -; mRNA.
DR EMBL; AK046408; BAC32712.1; -; mRNA.
DR EMBL; AK079541; BAC37676.1; -; mRNA.
DR EMBL; AK135091; BAE22417.1; -; mRNA.
DR EMBL; BC025646; AAH25646.1; -; mRNA.
DR CCDS; CCDS40679.1; -.
DR RefSeq; NP_084060.1; NM_029784.2.
DR RefSeq; XP_006511613.1; XM_006511550.3.
DR RefSeq; XP_006511614.1; XM_006511551.2.
DR AlphaFoldDB; Q3UXZ6; -.
DR SMR; Q3UXZ6; -.
DR BioGRID; 218377; 2.
DR IntAct; Q3UXZ6; 3.
DR MINT; Q3UXZ6; -.
DR STRING; 10090.ENSMUSP00000034749; -.
DR iPTMnet; Q3UXZ6; -.
DR PhosphoSitePlus; Q3UXZ6; -.
DR MaxQB; Q3UXZ6; -.
DR PaxDb; Q3UXZ6; -.
DR PeptideAtlas; Q3UXZ6; -.
DR PRIDE; Q3UXZ6; -.
DR ProteomicsDB; 267697; -.
DR Antibodypedia; 42746; 73 antibodies from 14 providers.
DR DNASU; 76886; -.
DR Ensembl; ENSMUST00000034749; ENSMUSP00000034749; ENSMUSG00000032224.
DR GeneID; 76886; -.
DR KEGG; mmu:76886; -.
DR UCSC; uc009qnu.1; mouse.
DR CTD; 145773; -.
DR MGI; MGI:1924136; Fam81a.
DR VEuPathDB; HostDB:ENSMUSG00000032224; -.
DR eggNOG; ENOG502S0X8; Eukaryota.
DR GeneTree; ENSGT00390000004985; -.
DR HOGENOM; CLU_056304_1_0_1; -.
DR InParanoid; Q3UXZ6; -.
DR OMA; KQEVPRW; -.
DR OrthoDB; 1102797at2759; -.
DR PhylomeDB; Q3UXZ6; -.
DR TreeFam; TF335682; -.
DR BioGRID-ORCS; 76886; 1 hit in 70 CRISPR screens.
DR ChiTaRS; Fam81a; mouse.
DR PRO; PR:Q3UXZ6; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q3UXZ6; protein.
DR Bgee; ENSMUSG00000032224; Expressed in choroid plexus epithelium and 188 other tissues.
DR ExpressionAtlas; Q3UXZ6; baseline and differential.
DR Genevisible; Q3UXZ6; MM.
DR InterPro; IPR029619; FAM81.
DR InterPro; IPR029622; FAM81A.
DR PANTHER; PTHR22420; PTHR22420; 1.
DR PANTHER; PTHR22420:SF2; PTHR22420:SF2; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..364
FT /note="Protein FAM81A"
FT /id="PRO_0000265120"
FT REGION 281..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 75..107
FT /evidence="ECO:0000255"
FT COILED 158..189
FT /evidence="ECO:0000255"
FT COILED 261..287
FT /evidence="ECO:0000255"
FT CONFLICT 31
FT /note="E -> K (in Ref. 1; BAE22417)"
FT /evidence="ECO:0000305"
FT CONFLICT 32
FT /note="D -> K (in Ref. 1; BAC37676)"
FT /evidence="ECO:0000305"
FT CONFLICT 43..64
FT /note="ALVEHAFRIKDDIVSSLQKMQN -> GTGWSMASGFKMKSSQFGKKCRI
FT (in Ref. 1; BAC37676)"
FT /evidence="ECO:0000305"
FT CONFLICT 68
FT /note="G -> S (in Ref. 1; BAC37676)"
FT /evidence="ECO:0000305"
FT CONFLICT 122..139
FT /note="QLSGLGDLRGRVARCDAS -> HSLAWEISEEELQSATPT (in Ref. 1;
FT BAB31146)"
FT /evidence="ECO:0000305"
FT CONFLICT 189
FT /note="S -> Y (in Ref. 1; BAC32712)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 364 AA; 41710 MW; 78CA6C1F25CB7B42 CRC64;
MHLRRVKTMP RHSQSLTMAP YSSVSLVEQL EDRILCHEKT TAALVEHAFR IKDDIVSSLQ
KMQNKGGGDR LARLFLEEHI RNITAIVKQL NRDIEVLQEQ IRARDNISYG TNSALKTLEM
RQLSGLGDLR GRVARCDASI ARLSAEHKST YEGLQHLNKE QQAAKLILET KIKDAEGQIS
QLLSRVDLSI SEQSTKLKMS HRDSNHQLQL LDTKFKGTVE ELSNQILSAR SWLQQEQERI
EKELLQKIDH LSLIVKENSG ANERDVEKKL SQMSARLDKI EESQKRNAEG QRKPDEEKVH
GRISKLELQM TEDMKEMKAE VNAGFSAIYE SIGSLRQVLE AKMKLDRDQL QKQIQQMQKP
ETAM
