FA81B_HUMAN
ID FA81B_HUMAN Reviewed; 452 AA.
AC Q96LP2;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2020, sequence version 4.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Protein FAM81B;
GN Name=FAM81B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q96LP2; Q8IY31-3: IFT20; NbExp=3; IntAct=EBI-10290827, EBI-9091197;
CC Q96LP2; Q9Y250: LZTS1; NbExp=3; IntAct=EBI-10290827, EBI-1216080;
CC Q96LP2; Q6NUQ1: RINT1; NbExp=5; IntAct=EBI-10290827, EBI-726876;
CC Q96LP2; Q15287: RNPS1; NbExp=3; IntAct=EBI-10290827, EBI-395959;
CC Q96LP2; Q8N720: ZNF655; NbExp=3; IntAct=EBI-10290827, EBI-625509;
CC -!- SIMILARITY: Belongs to the FAM81 family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-39 is the initiator. Met-
CC 1 does not seem to exist in orthologs. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH34772.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB71646.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK058062; BAB71646.1; ALT_FRAME; mRNA.
DR EMBL; AC008573; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC090071; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC034772; AAH34772.1; ALT_INIT; mRNA.
DR CCDS; CCDS43341.1; -.
DR RefSeq; NP_689761.2; NM_152548.2.
DR AlphaFoldDB; Q96LP2; -.
DR SMR; Q96LP2; -.
DR BioGRID; 127508; 18.
DR IntAct; Q96LP2; 9.
DR STRING; 9606.ENSP00000283357; -.
DR iPTMnet; Q96LP2; -.
DR PhosphoSitePlus; Q96LP2; -.
DR BioMuta; FAM81B; -.
DR DMDM; 296439348; -.
DR MassIVE; Q96LP2; -.
DR MaxQB; Q96LP2; -.
DR PaxDb; Q96LP2; -.
DR PeptideAtlas; Q96LP2; -.
DR PRIDE; Q96LP2; -.
DR ProteomicsDB; 77230; -.
DR Antibodypedia; 54483; 43 antibodies from 16 providers.
DR DNASU; 153643; -.
DR Ensembl; ENST00000283357.10; ENSP00000283357.5; ENSG00000153347.10.
DR GeneID; 153643; -.
DR KEGG; hsa:153643; -.
DR MANE-Select; ENST00000283357.10; ENSP00000283357.5; NM_152548.3; NP_689761.2.
DR UCSC; uc003kla.2; human.
DR CTD; 153643; -.
DR GeneCards; FAM81B; -.
DR HGNC; HGNC:26335; FAM81B.
DR HPA; ENSG00000153347; Group enriched (fallopian tube, testis).
DR neXtProt; NX_Q96LP2; -.
DR OpenTargets; ENSG00000153347; -.
DR PharmGKB; PA142671847; -.
DR VEuPathDB; HostDB:ENSG00000153347; -.
DR eggNOG; ENOG502QPWB; Eukaryota.
DR GeneTree; ENSGT00390000004985; -.
DR HOGENOM; CLU_056304_0_0_1; -.
DR InParanoid; Q96LP2; -.
DR OMA; WGELEKM; -.
DR OrthoDB; 1102797at2759; -.
DR PhylomeDB; Q96LP2; -.
DR TreeFam; TF335682; -.
DR PathwayCommons; Q96LP2; -.
DR SignaLink; Q96LP2; -.
DR BioGRID-ORCS; 153643; 7 hits in 1071 CRISPR screens.
DR ChiTaRS; FAM81B; human.
DR GenomeRNAi; 153643; -.
DR Pharos; Q96LP2; Tdark.
DR PRO; PR:Q96LP2; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q96LP2; protein.
DR Bgee; ENSG00000153347; Expressed in bronchial epithelial cell and 123 other tissues.
DR ExpressionAtlas; Q96LP2; baseline and differential.
DR Genevisible; Q96LP2; HS.
DR GO; GO:0005634; C:nucleus; HDA:UniProtKB.
DR InterPro; IPR029619; FAM81.
DR InterPro; IPR029620; FAM81B.
DR PANTHER; PTHR22420; PTHR22420; 1.
DR PANTHER; PTHR22420:SF5; PTHR22420:SF5; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..452
FT /note="Protein FAM81B"
FT /id="PRO_0000265122"
FT REGION 1..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 164..192
FT /evidence="ECO:0000255"
FT COILED 329..452
FT /evidence="ECO:0000255"
FT COMPBIAS 24..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 150
FT /note="R -> G (in dbSNP:rs10042271)"
FT /id="VAR_057968"
FT VARIANT 187
FT /note="A -> V (in dbSNP:rs11555275)"
FT /id="VAR_057969"
FT VARIANT 239
FT /note="R -> Q (in dbSNP:rs1541797)"
FT /id="VAR_057970"
FT VARIANT 275
FT /note="S -> P (in dbSNP:rs6878669)"
FT /id="VAR_057971"
SQ SEQUENCE 452 AA; 52022 MW; B12CAB0998E7D23A CRC64;
MQLQFLGTLA SSEKRKKSQR LFFKNIKSTK NKAGKASIMS SDTNVNKSAS PTATAEEQPV
EPDGPLPGSD NNQEKKVRLS PAKMSTKNST DLVEYVDKSH AFLPIIPNTQ RGQLEDRLNN
QARTIAFLLE QAFRIKEDIS ACLQGTHGFR KEESLARKLL ESHIQTITSI VKKLSQNIEI
LEDQIRARDQ AATGTNFAVH EINIKHLQGV GDLRGRVARC DSSIVKLSGD IHLFRQEHRQ
IEKAIQEFVP ALETLSKNLD MKVMQLLGKI ETASSEQTSN LKMVQGDYRH EMNLLEFKFH
SLSSNLYEEV ENNKKWTENQ FLKYRKDHLG HINECLKVLQ EKLEKSENKM EEKLLQLSSK
VENFINTQKQ ETQLSKVKHM ENKLSKKMEQ MEKQIWGELE TMQNEYQSGF KSIHDSLSSL
QQIQKTKMDL EKYKVQKDLK KLQRKIVELQ EV
