FA83A_MOUSE
ID FA83A_MOUSE Reviewed; 436 AA.
AC Q8K2P2;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Protein FAM83A {ECO:0000305};
GN Name=Fam83a {ECO:0000312|MGI:MGI:2447773};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Probable proto-oncogene that functions in the epidermal
CC growth factor receptor/EGFR signaling pathway. Activates both RAS/MAPK
CC and PI3K/AKT/TOR signaling cascades downstream of EGFR. Required for
CC the RAS/MAPK signaling cascade activation upon EGFR stimulation, it
CC also activates both signaling cascades independently of EGFR
CC activation. {ECO:0000250|UniProtKB:Q86UY5}.
CC -!- SUBUNIT: Interacts with the regulatory subunit p85 of PI3-kinase;
CC increased by EGFR activation. Interacts with RAF1; increased by EGFR
CC activation it activates RAF1. {ECO:0000250|UniProtKB:Q86UY5}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q86UY5}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8K2P2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8K2P2-2; Sequence=VSP_025192, VSP_025193;
CC -!- PTM: Phosphorylated upon EGFR activation.
CC {ECO:0000250|UniProtKB:Q86UY5}.
CC -!- SIMILARITY: Belongs to the FAM83 family. {ECO:0000305}.
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DR EMBL; AC107760; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC030396; AAH30396.1; -; mRNA.
DR CCDS; CCDS27486.2; -. [Q8K2P2-1]
DR RefSeq; NP_776287.2; NM_173862.2. [Q8K2P2-1]
DR AlphaFoldDB; Q8K2P2; -.
DR SMR; Q8K2P2; -.
DR STRING; 10090.ENSMUSP00000125464; -.
DR iPTMnet; Q8K2P2; -.
DR PhosphoSitePlus; Q8K2P2; -.
DR PaxDb; Q8K2P2; -.
DR PRIDE; Q8K2P2; -.
DR ProteomicsDB; 266830; -. [Q8K2P2-1]
DR ProteomicsDB; 266831; -. [Q8K2P2-2]
DR Antibodypedia; 64700; 82 antibodies from 18 providers.
DR Ensembl; ENSMUST00000050374; ENSMUSP00000050051; ENSMUSG00000051225. [Q8K2P2-2]
DR Ensembl; ENSMUST00000160942; ENSMUSP00000125464; ENSMUSG00000051225. [Q8K2P2-1]
DR GeneID; 239463; -.
DR KEGG; mmu:239463; -.
DR UCSC; uc007vsz.2; mouse. [Q8K2P2-2]
DR UCSC; uc011zta.1; mouse. [Q8K2P2-1]
DR CTD; 84985; -.
DR MGI; MGI:2447773; Fam83a.
DR VEuPathDB; HostDB:ENSMUSG00000051225; -.
DR eggNOG; ENOG502QQDU; Eukaryota.
DR GeneTree; ENSGT00940000160768; -.
DR HOGENOM; CLU_019056_3_1_1; -.
DR InParanoid; Q8K2P2; -.
DR OMA; YSFSWLC; -.
DR OrthoDB; 550760at2759; -.
DR PhylomeDB; Q8K2P2; -.
DR TreeFam; TF330777; -.
DR BioGRID-ORCS; 239463; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Fam83a; mouse.
DR PRO; PR:Q8K2P2; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q8K2P2; protein.
DR Bgee; ENSMUSG00000051225; Expressed in white adipose tissue and 32 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0036312; F:phosphatidylinositol 3-kinase regulatory subunit binding; ISO:MGI.
DR GO; GO:0019901; F:protein kinase binding; ISS:UniProtKB.
DR GO; GO:0008283; P:cell population proliferation; ISS:UniProtKB.
DR GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR012461; FAM83_N.
DR Pfam; PF07894; FAM83; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Phosphoprotein; Proto-oncogene;
KW Reference proteome.
FT CHAIN 1..436
FT /note="Protein FAM83A"
FT /id="PRO_0000286814"
FT REGION 73..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 302..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 318..358
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 301
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q86UY5"
FT MOD_RES 329
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q86UY5"
FT MOD_RES 350
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q86UY5"
FT MOD_RES 359
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q86UY5"
FT VAR_SEQ 258
FT /note="S -> R (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_025192"
FT VAR_SEQ 259..436
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_025193"
FT CONFLICT 196
FT /note="G -> A (in Ref. 2; AAH30396)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 436 AA; 48193 MW; 300C3CBD049A4EFB CRC64;
MSRSRHVGKI RKRLEDVKNQ WTRPARADFS DNESARLATD ALLDGGPEAY WRALSQEGEV
DFLSSAEAQY IQAQAKEPPD APDSAGGAES GPRGLDSCSL QSGTYFPVAS EGSEPALLHT
WTLAEKPYLK EKSSATIYFQ MDKHNNIRDL VRRCISRASQ VLAILMDVFT DVEILCDILE
AANKRGVFVC VLLDQGGVKL FQEMCDKVQI SDIHLKNISI RSVEGEVYCA KSGRKFAGQI
QEKFIISDWR FVLSGSYSFS WLCGHVHRNI LSKFTGQAVE LFDEEFRRLY ASSKPLMGLK
SPRLVAPFQP NKGPEAPNGR LSGTSDSASD RTSSNPFSSL STGSNAHNQS LSTSSGPSSP
LAPIPPTVPR LQPYHSTRRA VAPQPLLVPM RPHEGAPAPY SSLMAYRPTR LQLQQLGLVP
RVTHPWRPFL QALPHF
