FA83C_MOUSE
ID FA83C_MOUSE Reviewed; 776 AA.
AC A2ARK0; Q14CG2;
DT 11-NOV-2015, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Protein FAM83C {ECO:0000305};
GN Name=Fam83c {ECO:0000312|MGI:MGI:1918655};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a role in MAPK signaling.
CC {ECO:0000250|UniProtKB:Q9BQN1}.
CC -!- SUBUNIT: May interact with RAF1. {ECO:0000250|UniProtKB:Q9BQN1}.
CC -!- SIMILARITY: Belongs to the FAM83 family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-47 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI13191.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI13798.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AL845445; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC113190; AAI13191.1; ALT_INIT; mRNA.
DR EMBL; BC113797; AAI13798.1; ALT_INIT; mRNA.
DR RefSeq; NP_082064.2; NM_027788.2.
DR AlphaFoldDB; A2ARK0; -.
DR SMR; A2ARK0; -.
DR STRING; 10090.ENSMUSP00000029143; -.
DR iPTMnet; A2ARK0; -.
DR PhosphoSitePlus; A2ARK0; -.
DR PaxDb; A2ARK0; -.
DR PRIDE; A2ARK0; -.
DR ProteomicsDB; 277031; -.
DR Antibodypedia; 74559; 8 antibodies from 7 providers.
DR Ensembl; ENSMUST00000239423; ENSMUSP00000159338; ENSMUSG00000074647.
DR GeneID; 71405; -.
DR KEGG; mmu:71405; -.
DR UCSC; uc008nlm.2; mouse.
DR CTD; 128876; -.
DR MGI; MGI:1918655; Fam83c.
DR VEuPathDB; HostDB:ENSMUSG00000074647; -.
DR eggNOG; ENOG502QQ4N; Eukaryota.
DR GeneTree; ENSGT00940000160254; -.
DR HOGENOM; CLU_020214_0_0_1; -.
DR InParanoid; A2ARK0; -.
DR OMA; GFCGGED; -.
DR OrthoDB; 421095at2759; -.
DR PhylomeDB; A2ARK0; -.
DR TreeFam; TF330777; -.
DR BioGRID-ORCS; 71405; 0 hits in 70 CRISPR screens.
DR ChiTaRS; Fam83c; mouse.
DR PRO; PR:A2ARK0; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; A2ARK0; protein.
DR Bgee; ENSMUSG00000074647; Expressed in lip and 19 other tissues.
DR ExpressionAtlas; A2ARK0; baseline and differential.
DR GO; GO:0019901; F:protein kinase binding; ISO:MGI.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR012461; FAM83_N.
DR Pfam; PF07894; FAM83; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..776
FT /note="Protein FAM83C"
FT /id="PRO_0000434566"
FT REGION 344..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 494..565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 617..653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 669..694
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 716..745
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 366..387
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..467
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 527..542
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 343
FT /note="S -> G (in Ref. 2; AAI13191/AAI13798)"
FT /evidence="ECO:0000305"
FT CONFLICT 546
FT /note="A -> V (in Ref. 2; AAI13191/AAI13798)"
FT /evidence="ECO:0000305"
FT CONFLICT 566
FT /note="R -> G (in Ref. 2; AAI13191/AAI13798)"
FT /evidence="ECO:0000305"
FT CONFLICT 634
FT /note="I -> M (in Ref. 2; AAI13191/AAI13798)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 776 AA; 84071 MW; BA89B2C7490A469D CRC64;
MQGCQAGASI FFLIAANPDA NHGASGGLGS RWIRTFSRIA PAGTQGMAGP LRSRVEELKR
PWWRESSPLV LQHSEAARLA ADALLERGEA AYLQVISEER ELPFLSALDV DYMISHVRGV
PELSEAQGSE TLGQDLSMLS EVTSGTYFPM ASDLDPPDLD LGWPEVPQAT GFSPTQAVVH
FQRDKGKSIK DLLRFLFSQA QTVVAVVMDV FTDMELLCDL MEASSRRGVP VYLLLAQEHL
KYFLEMCYKM DLNGGHLVNM RVRSTCGDTY CSKAGRRFTG QALEKFVIID CEQVVAGSYS
FTWLCSQAHT SMVLQLRGHI VEDFDREFRC LYAESQPVEG FCSNEDPLMP QVPRPPPVTL
AFGPAVPSAT GSSPSSNSLS SIKHSPLLAR SSYLALPGGG GRNDMGMGSS SPGPAYHEAG
GQPSLYRQLS DPNHISPPGP YRANLSKLGA SPWSQSSPAL NHSSTSPLTL AVGSPLLPSS
RPLLHFTRGV PALSRLPENG LPASQDPSLP RGRWVPGTAL ETVEEKKVSL SQSHDHLDRL
SPFSKAGEAG GPNSRVTPDS SSLQHRELAL DDRRLSLSHS HSQLDLLSQG QGVLESGSLR
PGELSLENRK LSLNHNHGQL DLLPQNPKPQ APKIPSDAYS SAGPSKPSLD DRRQTLGHSQ
LDLITKFGPF RSEGPGPSCP PEPSPVRMAG VGSADEKRLT LGHSKLDLIT KYHQLQGARQ
KPEPGIPGAP VSGHQNGSSN DLFAPEKRLT LGHSKLDLIT KYNKSKFKQL RSRFES
