ID   FA83D_DANRE             Reviewed;         534 AA.
AC   A4QP72;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Protein FAM83D {ECO:0000305};
GN   Name=fam83d {ECO:0000250|UniProtKB:Q9H4H8};
GN   ORFNames=zgc:162965 {ECO:0000312|EMBL:AAI39680.1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May regulate cell proliferation, growth, migration and
CC       epithelial to mesenchymal transition. May also be important for proper
CC       chromosome congression and alignment during mitosis.
CC       {ECO:0000250|UniProtKB:Q9H4H8}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9H4H8}.
CC       Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9H4H8}.
CC       Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q9H4H8}.
CC   -!- SIMILARITY: Belongs to the FAM83 family. {ECO:0000305}.
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DR   EMBL; BC139679; AAI39680.1; -; mRNA.
DR   RefSeq; NP_001082824.1; NM_001089355.1.
DR   AlphaFoldDB; A4QP72; -.
DR   SMR; A4QP72; -.
DR   STRING; 7955.ENSDARP00000107897; -.
DR   PaxDb; A4QP72; -.
DR   PRIDE; A4QP72; -.
DR   GeneID; 492689; -.
DR   KEGG; dre:492689; -.
DR   CTD; 81610; -.
DR   ZFIN; ZDB-GENE-041111-264; fam83d.
DR   eggNOG; ENOG502RC3Z; Eukaryota.
DR   InParanoid; A4QP72; -.
DR   OrthoDB; 433035at2759; -.
DR   PhylomeDB; A4QP72; -.
DR   PRO; PR:A4QP72; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0097431; C:mitotic spindle pole; ISS:UniProtKB.
DR   GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0008283; P:cell population proliferation; ISS:UniProtKB.
DR   GO; GO:0051310; P:metaphase plate congression; ISS:UniProtKB.
DR   GO; GO:1902808; P:positive regulation of cell cycle G1/S phase transition; IBA:GO_Central.
DR   GO; GO:1902480; P:protein localization to mitotic spindle; IBA:GO_Central.
DR   GO; GO:0070372; P:regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.
DR   GO; GO:0032006; P:regulation of TOR signaling; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   InterPro; IPR012461; FAM83_N.
DR   Pfam; PF07894; FAM83; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Cytoplasm; Cytoskeleton; Mitosis;
KW   Reference proteome.
FT   CHAIN           1..534
FT                   /note="Protein FAM83D"
FT                   /id="PRO_0000365009"
FT   REGION          320..372
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          501..534
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        325..346
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        349..363
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        509..524
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   534 AA;  60002 MW;  93A099528945443D CRC64;
     MALSQCLEDS PGWRTPRKEQ DSNLNELYNE RHRLALEELV AGGVQSFMGF LKKERMPNFL
     SEDEIRRVSR AAVVPKTISI NGDDSHLDQS GTLDCSSVTY FPEVSDIEPP VLENGWPAFT
     TGSYRGVTRA VAYFQPSYGE CIYSCKEAAR RMIRNAKEVI AIVTDSMTDL DIFHDLREAC
     TRRRVPVYIL LDQSSVASFL QMCKNLCVHL DELLQMKVRT ITGSTYYMRS GARITGKVHE
     RFMLIDGNKV ATGSYRFNWT DGKLNSSNLI ELSGQITEKF DEEFRILYAQ SLPLPVNTRA
     PSSARNCSLY DHLVLKAPGT PPSYLARTTK PQAERLTSTP ARLQTPEIQR MNKDIEEPDR
     KSNPVSDSST LGEDLELPLA SADPPRLPST TVNSQTQTVD VTIVSCCDVS TQTTCHTADV
     SVQTCKEPQN SKPSSEHQEV DSCPPICPLP QDVNFRECFL KITKERQHHY SSIRSKLDHM
     VTLLSHKREL VDLTNLPLRP GLNRGRKAQQ EARQPNTNID SGIMGTWPKS RGLQ